Regulatory Peptides
Papers 7,746
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#1Guldal Gulec-Suyen (Acıbadem University)
#2Naciye Isbil-Buyukcoskun (Uludağ University)H-Index: 7
Last. Kasim Ozluk (Uludağ University)H-Index: 9
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#1Judit Ágnes Ujhelyi (University of Debrecen)H-Index: 1
#2Zoltán Ujhelyi (University of Debrecen)H-Index: 12
Last. Róbert Pórszász (University of Debrecen)H-Index: 16
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To validate the potential anti-inflammatory and analgesic role of sita- and vildagliptin, five different experimental models were used in mice: i) mustard oil-induced ear edema, ii) neutrophil accumulation, iii) mechanical and iv) thermal touch sensitivity in complete Freund's adjuvant-induced arthritis and v) capsaicin-induced plasma extravasation in the urinary bladder. For the complete examination period in i) the dose of 10 mg sitagliptin as well as 1–10 mg vildagliptin was found to signific...
#1Manyi Sun (Tianjin Medical University General Hospital)H-Index: 1
#2Feng WangH-Index: 1
Last. Ping Feng (Tianjin Medical University General Hospital)H-Index: 1
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Abstract Cellular apoptosis and colonic dysmotility are involved in diabetes mellitus (DM) complications. Insulin-like growth factor-1 (IGF-1) is known to affect apoptosis and proliferation. Here, we demonstrated that the treatment of 1500 ng/kg IGF-1 partly recovers the decrease of the muscle thickness, body weight and gastrointestinal transit rate in DM rats. The gastrointestinal transit rate is positively correlated with the IGF-I level, but negatively correlated with the level of colonic cel...
#1Karen Jesus Oliveira (UFRJ: Federal University of Rio de Janeiro)H-Index: 16
#2Gabriela S. M. Paula (UFRJ: Federal University of Rio de Janeiro)H-Index: 7
Last. Carmen C. Pazos-Moura (UFRJ: Federal University of Rio de Janeiro)H-Index: 25
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Abstract Neuromedin B, a peptide highly expressed at the pituitary, has been shown to act as autocrine/paracrine inhibitor of thyrotropin (TSH) release. Here we studied the thyroid axis of adult female mice lacking neuromedin B receptor (NBR-KO), compared to wild type (WT) littermates. They exhibited slight increase in serum TSH (18%), with normal pituitary expression of mRNA coding for α-glycoprotein subunit ( Cga ), but reduced TSH β-subunit mRNA ( Tshb , 41%), lower intra-pituitary TSH conten...
#1Milena Mechkarska (United Arab Emirates University)H-Index: 22
#2Samir Attoub (United Arab Emirates University)H-Index: 33
Last. J. Michael Conlon (Ulster University)H-Index: 62
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Pseudhymenochirin-1Pb (Ps-1Pb) and pseudhymenochirin-2Pa (Ps-2Pa) are host-defense peptides, first isolated from skin secretions of the frog Pseudhymenochirus merlini (Pipidae). Ps-1Pb and Ps-2Pa are highly cytotoxic (LC50 < 12 μM) against non-small cell lung adenocarcinoma A549 cells, breast adenocarcinoma MDA-MB-231 cells, and colorectal adenocarcinoma HT-29 cells but are also hemolytic against human erythrocytes (LC50 = 28 ± 2 μM for Ps-1Pb and LC50 = 6 ± 1 μM for Ps-2Pa). Ps-2Pa shows select...
#1Neng Chen (Soochow University (Suzhou))H-Index: 5
#2Lingmei Zhou (Soochow University (Suzhou))H-Index: 4
Last. Li-Qiang Qin (Soochow University (Suzhou))H-Index: 36
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Abstract Resistin is an adipokine secreted from adipose tissue, which is likely involved in the development of obesity and insulin resistance via its interaction with other organs, as well as affecting adipose tissue function. The impact of resistin treatment on lipolysis and adiponectin secretion in human visceral adipose tissue is currently unknown. Mesenteric adipose tissue samples were obtained from 14 male subjects [age 54 ± 6 yr, body mass index (BMI) 23.59 ± 0.44 kg/m 2 ] undergoing abdom...
Abstract Glucagon-like peptide 2 [GLP-2] is a 33-amino acid peptide released from the mucosal enteroendocrine L-cells of the intestine. The actions of GLP-2 are transduced by the GLP-2 receptor [GLP-2R], which is localized in the neurons of the enteric nervous system but not in the intestinal epithelium, indicating an indirect mechanism of action. GLP-2 is well known for its trophic role within the intestine and interest in GLP-2 is now reviving based on the approval of the GLP-2R agonist for tr...
#1Hakimeh Saadati (KMU: Kerman Medical University)H-Index: 7
#2Vahid Sheibani (KMU: Kerman Medical University)H-Index: 26
Last. Shahrzad Mazhari (KMU: Kerman Medical University)H-Index: 15
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Abstract Previous studies indicated that brain-derived neurotrophic factor (BDNF) is the main candidate to mediate the beneficial effects of exercise on cognitive function in sleep deprived male rats. In addition, our previous findings demonstrate that female rats are more vulnerable to the deleterious effects of sleep deprivation on cognitive performance and synaptic plasticity. Therefore, the current study was designed to investigate the effects of treadmill exercise and/or sleep deprivation (...
#1Hye Seung Chung (KU: Korea University)H-Index: 1
#2Jae Gon Kim (KU: Korea University)H-Index: 3
Last. Bong June Yoon (KU: Korea University)H-Index: 20
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Abstract Orexin plays diverse roles in regulating behaviors, such as sleep and wake, reward processing, arousal, and stress and anxiety. The orexin system may accomplish these multiple tasks through its complex innervations throughout the brain. The emerging evidence indicates a role of orexin in emotional behaviors; however, most of the previous studies have investigated the function of orexin in naive animals. Here, we examined a functional role of orexin in mice that had been exposed to repea...
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