Drug Development and Industrial Pharmacy
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#1Shambhavi Borde (Creighton University)
#2Sagar Kumar Paul (Creighton University)
Last. Harsh Chauhan (Creighton University)H-Index: 14
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The number of active pharmaceutical compounds from the Biopharmaceutical classification system (BCS) belonging to Class II and IV have significantly increased in recent years. These compounds have high therapeutic potential but are difficult to formulate as oral dosage forms due to their poor aqueous solubility. The solubility and bioavailability of these poorly water-soluble compounds can be increased by various formulation approaches, such as amorphous solid dispersions (ASD), salt formation, ...
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#1S. Keppler (UC Davis: University of California, Davis)
#2G. Mannara (UNISA: University of Salerno)
Last. Gail M. Bornhorst (UC Davis: University of California, Davis)H-Index: 18
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OBJECTIVE Elucidate properties of raft-forming alginates in vitro with varying composition, system in which the raft was formed (HCl solution; tomato soup; protein-rich beverage), and pH levels for a more accurate representation of postprandial gastric conditions. SIGNIFICANCE Knowledge of the impact of food system and pH on properties of raft-forming alginates may aid in formulation optimization. Recommendations may be made on food that is consumed prior to their consumption to optimize efficac...
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#1Adila Khalil (AMU: Aligarh Muslim University)
#2Mohammad Kashif (AMU: Aligarh Muslim University)H-Index: 9
For cilazapril (CLZ), analytical methods based on donor-acceptor phenomenon that are simple, rapid with broad linear dynamic range for the quantification of drug are not available in the literature. Considering the requirement for the methods, in this study, two economic, potent analytical methods based on the complexation of CLZ with π-acceptors, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and 2,5-dichloro-3,6-dihydroxy-p-benzoquinone (CA) were developed, validated, and studied spectrophoto...
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#1Aimen Khalid (QAU: Quaid-i-Azam University)
#2Naveed Ahmed (QAU: Quaid-i-Azam University)H-Index: 18
Last. Asim Ur Rehman (QAU: Quaid-i-Azam University)H-Index: 11
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Objective null Biodegradable polymers are extensively used due to their efficient safety profiles. The aim of the current study was to fabricate, evaluate, and characterize biodegradable, biocompatible fluconazole (FLZ) loaded chitosan (CHS) chondroitin sulfate (CS) nanoparticles (NPs) for topical delivery. Polymers utilized in the formulation not only served as a carrier system but also aided in fighting with complex etiology of the disease due to their innate antifungal activities. null Method...
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#1Manish Kumar (Mohanlal Sukhadia University)H-Index: 2
#2Ram Singh Bishnoi (Mohanlal Sukhadia University)H-Index: 3
Last. C. P. Jain (Mohanlal Sukhadia University)H-Index: 5
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The objective of the present investigation was to develop a stable and optimized drug-loaded nanoemulsion system using the phase inversion temperature (PIT) method.The PIT method has been widely us...
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#1Wessam A. Sarhan (The: American University in Cairo)H-Index: 5
#2H. G. Salem (The: American University in Cairo)
Last. Hassan M.E. Azzazy (The: American University in Cairo)H-Index: 32
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OBJECTIVE The alarming rise of multi-drug resistant (MDR) Pseudomonas aeruginosa has prompted the World Health Organization to consider it a serious threat to human health. Although phage (Phg), an effective antibacterial treatment option, can maintain long-term infectivity via lyophilized storage, freeze-drying can be expensive and time-consuming. Thus, we propose electrospun gelatin/fibroin (G/F) nanofibrous formulation for dehydrating and storing phage against MDR P. aeruginosa. SIGNIFICANCE ...
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Objective null Parkinson Disease (PD) is a chronic disorder of central nervous system mainly affecting the motor systems. The drug of choice to treat PD is Rasagiline Mesylate (RM) and it belongs to BCS class III drug. The objective of the present study was preparation of transdermal drug delivery system for RM. Several permeation enhancers were screened to be included in the formulation. To achieve desired flux a new strategy was developed by including in-house prepared CTC to enhance the perme...
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OBJECTIVE The aim was to perform a comparative evaluation of composition and in vitro release performance of multisource acyclovir 5% creams. SIGNIFICANCE The outcome was analyzed in relation with the principles of the Topical drug Classification System (TCS). METHODS The in vitro drug release testing (IVRT) was based on selection of an inert artificial membrane and a medium providing sink conditions, and utilizing the vertical diffusion cells. US and European innovator products, with marked dif...
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#1Debanjan Kundu (IIT: Indian Institute of Technology (BHU) Varanasi)H-Index: 2
#2Vikash Kumar Dubey (IIT: Indian Institute of Technology (BHU) Varanasi)H-Index: 27
Acetylcholinesterase/Butyrylcholinesterase inhibitors are considered an effective method for treating Alzheimer's disease (AD). In this current work, we have computationally analyzed 11 new small molecule drugs used in various neurological diseases and Donepezil, a known inhibitor of acetylcholinesterase, as a positive control. We investigated these drugs for possible fundamental interactions with acetylcholinesterase and butyrylcholinesterase as both are critical in the pathophysiology of Alzhe...
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#1Kumud Soni (Dr. Hari Singh Gour University)H-Index: 1
#2Vishal Gour (Dr. Hari Singh Gour University)H-Index: 2
Last. Vandana Soni (Dr. Hari Singh Gour University)H-Index: 17
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OBJECTIVE The objective of this study was to prepare and evaluate the doxycycline hyclate containing bigel for the effective treatment of acne. METHODS Bigels are biphasic systems formed by water-based hydrogels and oil-based organogel. Carbopol 940 was used to prepare the hydrogel phase, whereas Span-60 and olive oil for the oleogel phase. RESULTS The microstructure of bigel confirmed the oil in water type emulsion formation. The average droplet size of formulations was found 15-50 µm, and a be...
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