Anti-cancer Agents in Medicinal Chemistry
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2052
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BACKGROUND Cancer is a widespread fatal disease that is associated with abnormal growth of cells in the body. OBJECTIVES This article represent, applications of biologically synthesized silver nanoparticles and their mode of action in cancer therapy. METHODS Nanomedicines have been proved to be an effective therapy in the treatment of the disease because of a wide range of applications. Due to the small shape and size, these nanoparticles are emerging to be of novel importance. They are abundant...
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Background Autophagy is a cellular process that plays role in the destruction of proteins and organelles. It has been shown that impaired autophagic flux triggers canceration, infectious disease, and neurodegenerative diseases. It has been suggested that tumor formation is inhibited by autophagy that reduces oxidative stress and recycles damaged organelles. microRNAs are 17-25 bp in length, single-stranded, and non-coding small RNAs that play roles in the regulation of metabolic gene expression ...
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BACKGROUND It is estimated that more than 1 million people are diagnosed with liver malignancy each year and one of the treatments is radioembolization with Y-90 and Ho-166. null null Objective: The aim of this study is to calculate the absorbed doses caused by Y-90 and Ho-166 in tumor and liver parenchyma using a phantom via Monte Carlo method. null null Methods: A liver model phantom including a tumor imitation of sphere (r =1.5cm) was defined in GATE. The total activity of 40 mCi Y-90 and Ho-...
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Secondary metabolites have potential benefits to human being. They are used in the food, agricultural and pharmaceutical industries. The secondary metabolite of furanocoumarins from different plant sources is essential in various skin-related ailments. Biologically, these chemicals are isolated from different plants in the Apiaceae, Fabaceae, Rutaceae and Moraceae families. Ammi Majus L. is one of the most common plants in the family of Apiaceae with a large quantity of derivatives. The furanoco...
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Last. Ravindra Kumar Rawal (Maharishi Markandeshwar University, Mullana)H-Index: 5
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BACKGROUND Prostate cancer is considered the second most diagnosed cancer, and one of the most common causes of death from cancer in men. Apalutamide is an effective, safe, and well-tolerated agent used for the treatment of men with non-metastatic castration-resistant prostate cancer (nmCRPC) and metastatic hormone-naive prostate cancer (mHNPC). Androgen receptor signaling is a leading factor that drives these prostate tumors. USFDA has approved apalutamide on 14 February 2018 as an agent that t...
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#1Keyan Wu (YZU: Yangzhou University)H-Index: 6
#2Man Teng (YZU: Yangzhou University)
Last. Yanbing Ding (YZU: Yangzhou University)H-Index: 8
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OBJECTIVE The current study aimed to illustrate whether wogonin influences HCC cell cycle progression and apoptosis by regulating Hippo signaling. null null Methods: The effects of wogonin on HCC cell viability, cell cycle progression and apoptosis were analyzed by utilizing CCK-8 and flow cytometry. RNA-seq was employed to analyze the expression profiles between wogonin-treated and control HCC cells, and the selected RNA-seq transcripts were validated by reverse transcription-quantitative real-...
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#1Elham Ziaei (IUMS: Isfahan University of Medical Sciences)
#2Jaber Emami (IUMS: Isfahan University of Medical Sciences)H-Index: 22
Last. Moloud Kazemi (Ahvaz Jundishapur University of Medical Sciences)H-Index: 1
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BACKGROUND using a combination of chemotherapeutic agents with novel drug delivery platforms to enhance the anticancer efficacy of the drug and minimizing the side effects, is very imperative for lung cancer treatments. OBJECTIVE The aim of the present study was to develop, characterize, and optimize porous poly (D, L-lactic-co-glycolic acid) (PLGA) microparticles for simultaneous delivery of docetaxel (DTX) and celecoxib (CXB) through the pulmonary route for lung cancer. METHODS Drug-loaded por...
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#1Tatiane Renata Fagundes (UEL: Universidade Estadual de Londrina)H-Index: 2
#2Bruna Taciane da Silva Bortoleti (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 6
Last. Ivete Conchon-Costa (UEL: Universidade Estadual de Londrina)H-Index: 17
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Background null Conventional therapies for breast cancer is still a challenge due to use of cytotoxic drugs not highly effective with major adverse effects. Thiohydantoins, are biologically active heterocyclic compounds reported by several biological activities, including anticarcinogenic properties, i.e., this work aimed to assess the use of thiohydantoin as a potential antitumor agent against MCF-7 breast cancer cells. null Methods null MTT and neutral red assays were used to assess the possib...
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#1Dipanjan Karati (Bharati Vidyapeeth University)
#2Kakasaheb R. Mahadik (Bharati Vidyapeeth University)H-Index: 37
Last. Dileep Kumar (Bharati Vidyapeeth University)
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Cancer is considered one of the gruelling challenges and poses a grave health hazard across the globe. According to the International Agency for Research on Cancer (IARC), new cancer diagnoses increased to 18.1 million in 2018, with 9.6 million deaths, bringing the global cancer rate to 23.6 million by 2030. In 1942, the discovery of nitrogen mustard as an alkylating agent was a tremendous breakthrough in cancer chemotherapy. It acts by binding to the DNA, and creating cross linkages between the...
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Background null T-type calcium channels are aberrantly expressed in different human cancers and regulate cell cycle progression, proliferation, migration, and survival. FAK-1 can promote tumor protein degradation (p53) through ubiquitination, leading to cancer cell growth and proliferation. Similar findings are obtained regarding protease inhibitors' effect on cytokine-induced neutrophil activation that suppresses Granulocyte-macrophage colony-stimulating-factor (GM-CSF) TNF-α-induced O2 release...
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