Papers 8,448
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#1Heng Gao (ZJNU: Zhejiang Normal University)H-Index: 3
#2Shuzhen Peng (ZJNU: Zhejiang Normal University)H-Index: 1
Last. Yong Shao (ZJNU: Zhejiang Normal University)H-Index: 20
view all 9 authors...
G-triplex (G3) structures formed with three consecutive G-tracts have recently been identified as a new emerging guanine-rich DNA fold. There could likely be a wide range of biological functions for G3s as occurring for G-quadruplex (G4) structures formed with four consecutive G-tracts. However, in comparison to the many reports on G4 nanoassemblies that organize monomers together in a controllable manner, G3-favored nanoassemblies have yet to be explored. In this work, we found that a natural a...
#1Adriana Lozoya-Colinas (GT: Georgia Institute of Technology)H-Index: 3
#2Bryce E. Clifton (GT: Georgia Institute of Technology)H-Index: 2
Last. Nicholas V. Hud (GT: Georgia Institute of Technology)H-Index: 61
view all 4 authors...
For decades prebiotic chemists have attempted to achieve replication of RNA under prebiotic conditions with only limited success. One of the long-recognized impediments to achieving true replication of a duplex (copying of both strands) is the so-called strand inhibition problem. Specifically, while the two strands of an RNA (or DNA) duplex can be separated by heating, upon cooling the strands of a duplex will reanneal before mononucleotide or oligonucleotide substrates can bind to the individua...
#1Yuki Hirose (Kyoto University)H-Index: 2
#2Tomo Ohno (Kyoto University)H-Index: 1
Last. Hiroshi Sugiyama (Kyoto University)H-Index: 81
view all 6 authors...
Abnormally expanded CAG/CTG repeat DNA sequences lead to a variety of neurological diseases, such as Huntington's disease. Here, we synthesized a cyclic pyrrole-imidazole polyamide (cPIP), which can bind to the minor groove of the CAG/CTG DNA sequence. The double-stranded DNA melting temperature (Tm ) and surface plasmon resonance assays revealed the high binding affinity of the cPIP. In addition, next-generation sequencing showed that the cPIP had high specificity for its target DNA sequence.
#1Eike Siebs (Saarland University)H-Index: 3
#2Elena Shanina (MPG: Max Planck Society)H-Index: 7
Last. Alexander Titz (Saarland University)H-Index: 18
view all 10 authors...
Pseudomonas aeruginosa is an opportunistic ESKAPE pathogen that produces two lectins, LecA and LecB, as part of its large arsenal of virulence factors. Both carbohydrate-binding proteins are central to the initial and later persistent infection processes, i. e. bacterial adhesion and biofilm formation. The biofilm matrix is a major resistance determinant and protects the bacteria against external threats such as the host immune system or antibiotic treatment. Therefore, the development of drugs ...
#1Rebecca E. Moore (Vanderbilt University)H-Index: 6
#2Harrison C. Thomas (Vanderbilt University)H-Index: 3
Last. Steven D. Townsend (Vanderbilt University)H-Index: 18
view all 5 authors...
The members of the infant microbiome are governed by feeding method (breastmilk vs. formula). Regardless of the source of nutrition, a competitive growth advantage can be provided to commensals through prebiotics - either human milk oligosaccharides (HMOs) or plant oligosaccharides that are supplemented into formula. To characterize how prebiotics modulate commensal - pathogen interactions, we have designed and studied a minimal microbiome where a pathogen, Streptococcus agalactiae engages with ...
#1Ottavia Bellotto (UNITS: University of Trieste)H-Index: 5
#2Slavko Kralj (UL: University of Ljubljana)
Last. Silvia Marchesan (UNITS: University of Trieste)H-Index: 31
view all 8 authors...
Unprotected dipeptides are attractive building blocks for environmentally friendly hydrogel biomaterials by virtue of their low-cost and ease of preparation. This work investigates the self-assembling behaviour of the distinct stereoisomers of Ile-Phe and Phe-Ile in phosphate buffered saline (PBS) to form hydrogels, using transmission electron microscopy (TEM), attenuated total reflectance infrared spectroscopy (ATR-IR), circular dichroism (CD), and oscillatory rheometry. Each peptide purity and...
#1Takashi Kurohara (Osaka University)H-Index: 4
#2Keita Tanaka (Fujifilm)
Last. Koji Hase (Keio University)H-Index: 55
view all 11 authors...
#1Sachin B. Wagh (Texas State University)H-Index: 1
#2Vladimir Maslivetc (Texas State University)H-Index: 1
Last. Alexander Kornienko (Texas State University)H-Index: 38
view all 4 authors...
Fluorescent probes have gained a profound use in biotechnology, drug discovery, medical diagnostics, molecular and cell biology. The development of methods for the translation of flurophores into fluorescent probes continues to be a robust field for medicinal chemists and chemical biologists, alike. Here, access to new experimental designs has enabled molecular diversification and led to the identification of new approaches to probe discovery. This review provides a synopsis of the recent lesson...
#1Lea S. van Husen (Science for Life Laboratory)H-Index: 1
#2Anna-Maria Katsori (Science for Life Laboratory)H-Index: 8
Last. Simon J. Elsässer (Science for Life Laboratory)H-Index: 15
view all 6 authors...
#1Takanori Kondo (Keio University)
#2Chihiro Yasui (Keio University)
Last. Kazunobu Toshima (Keio University)H-Index: 54
view all 12 authors...
Mannosylerythritol lipids (MELs), which are one of the representative sugar-based biosurfactants (BSs) produced by microorganisms, have attracted much attention in various fields in the sustainable development goals (SDGs) era. However, they are inseparable mixtures with respect to the chain length of the fatty acids. In this study, self-assembling properties and structure-activity relationship (SAR) studies of recovery effects on damaged skin cells using chemically synthesized MELs were investi...
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