Seminars in Neurology
Papers 2054
1 page of 206 pages (2,054 results)
#1Ligia V Onofrei (UofU: University of Utah)H-Index: 1
#2A. Michael Henrie (UofU: University of Utah)H-Index: 4
Spondylotic myelopathies are among the most common disorders of the spine, yet the clinical and treatment approach is far from standardized. This article discusses our current understanding of the epidemiology, pathophysiology, clinical assessment, natural history, and treatment options in degenerative myelopathies of the cervical and thoracic spine. We additionally review diagnostic modalities including imaging modalities of the spine and neurophysiological tools such as electromyography/nerve ...
#1Alice C. Shea (Brigham and Women's Hospital)
#1Alice C. Shea (Brigham and Women's Hospital)
Last. Liangge Hsu (Brigham and Women's Hospital)
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Multiple diverse pathologies result in the clinical presentation of myelopathy. The preferred way to image the spinal cord depends on clinical history, anatomic site of interest, and patient issues limiting certain imaging modalities. This radiology-focused article discusses pertinent physiological considerations, reviews basic and newer imaging techniques, and examines several distinct disease entities in order to highlight the key role of imaging in the work-up of myelopathy.
Metabolic and toxic causes of myelopathy form a heterogeneous group of disorders. In this review, we discuss the causes of metabolic and toxic myelopathies with respect to clinical presentation, pathophysiology, diagnostic testing, treatment, and prognosis. This review is organized by temporal course (hyperacute, acute, subacute, and chronic) and etiology (e.g., nutritional deficiency, toxic exposure). Broadly, the myelopathies associated with dietary toxins (neurolathyrism, konzo) and decompres...
#1Kevin T. Huang (Brigham and Women's Hospital)H-Index: 13
#2Yi Lu (Brigham and Women's Hospital)H-Index: 14
Traumatic spinal cord injury (tSCI) is a life-changing and potentially overwhelming event. The sudden disruption of the spinal cord's integrity necessitates rapid attention at a specialized medical center, and involves a multilateral collaboration between neurologists, spine surgeons, critical care physicians, and trauma specialists. Even with care under ideal conditions, many tSCI patients have significant disability that persists for the rest of their lives. However, recently, we have seen a p...
#1Stephen W. English (Mayo Clinic)H-Index: 3
#2Nicholas L. Zalewski (Mayo Clinic)H-Index: 10
Vascular disorders of the spinal cord are uncommon yet under-recognized causes of myelopathy. Etiologies can be predominantly categorized into clinical and radiographic presentations of arterial ischemia, venous congestion/ischemia, hematomyelia, and extraparenchymal hemorrhage. While vascular myelopathies often produce significant morbidity, recent advances in the understanding and recognition of these disorders should continue to expedite diagnosis and proper management, and ideally improve pa...
#1Aaron M. Gusdon (University of Texas Health Science Center at Houston)H-Index: 10
#2Salia Farrokh (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 5
Last. James C. Grotta (TMC: Texas Medical Center)H-Index: 70
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Prevention of ischemic stroke relies on the use of antithrombotic medications comprising antiplatelet agents and anticoagulation. Stroke risk is particularly high in patients with cardiovascular disease. This review will focus on the role of antithrombotic therapies in the context of different types of cardiovascular disease. We will discuss oral antiplatelet medications and both IV and parental anticoagulants. Different kinds of cardiovascular disease contribute to stroke via distinct pathophys...
#1Anusha Boyanpally (Brown University)
#2Shawna Cutting (Brown University)H-Index: 13
Last. Karen L. Furie (Brown University)H-Index: 74
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Acute ischemic stroke (AIS) and acute myocardial infarction (AMI) may co-occur simultaneously or in close temporal succession, with occurrence of one ischemic vascular event increasing a patient's risk for the other. Both employ time-sensitive treatments, and both benefit from expert consultation. Patients are at increased risk of stroke for up to 3 months following AMI, and aggressive treatment of AMI, including use of reperfusion therapy, decreases the risk of AIS. For patients presenting with...
#1Amra Sakusic (Mayo Clinic)H-Index: 7
#2Alejandro A. Rabinstein (Mayo Clinic)H-Index: 63
Neurological complications after heart transplantation are common and include cerebrovascular events (ischemic strokes, hemorrhagic strokes, and transient ischemic attacks), seizures, encephalopathy, central nervous system (CNS) infections, malignancies, and peripheral nervous system complications. Although most neurological complications are transient, strokes and CNS infections can result in high mortality and morbidity. Early recognition and timely management of these serious complications ar...
#1Hyeyoung Seol (University of Texas Health Science Center at Houston)
#2Jong S. Kim (Asan Medical Center)
Heart failure (HF) and stroke, two of the major causes of death worldwide, are closely associated. Although atrial fibrillation (AF), which occurs in more than half of patients with HF, is a major risk factor for stroke, there is a great deal of evidence that HF itself increases the risk of stroke independent of AF. The main mechanism of stroke appears to be thromboembolism. However, previous studies have failed to demonstrate the benefit of warfarin in patients with HF without AF, as the benefi...
#1Giovanni Chiarini (Maastricht University Medical Centre)H-Index: 1
#2Sung-Min Cho (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 12
Last. Roberto Lorusso (Maastricht University Medical Centre)H-Index: 44
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Extracorporeal membrane oxygenation (ECMO) represents an established technique to provide temporary cardiac and/or pulmonary support. ECMO, in veno-venous, veno-arterial or in extracorporeal carbon dioxide removal modality, is associated with a high rate of brain injuries. These complications have been reported in 7 to 15% of adults and 20% of neonates, and are associated with poor survival. Thromboembolic events, loss of cerebral autoregulation, alteration of the blood-brain barrier, and hemorr...
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