Progress in Neuro-psychopharmacology & Biological Psychiatry
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#1Nana Baidoo (U of G: University of Guelph)H-Index: 2
#2Francesco Leri (U of G: University of Guelph)H-Index: 24
Abstract null null Opioid withdrawal can be associated to environmental cues through classical conditioning. Exposure to these cues can precipitate a state of conditioned withdrawal in abstinent subjects, and there are suggestions that conditioned withdrawal can perpetuate the addiction cycle in part by promoting the storage of newly acquired memories. This review discusses evidence supporting the hypothesis that conditioned withdrawal facilitates memory consolidation by activating a neurocircui...
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#1Namiko Kawamura (Kadai: Kagoshima University)H-Index: 2
#2Ela Novianti (Kadai: Kagoshima University)
Last. Akio Inui (Kadai: Kagoshima University)H-Index: 71
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The mesolimbic dopamine system is important for the rewarding and motivational aspects of consuming rewarding and palatable food. Nicotinic receptors are present in the mesolimbic dopamine system and enhance the reinforcement of drugs of abuse. In this study, we examined the involvement of nicotine receptor subtypes in sucrose addiction in a sucrose preference paradigm. Sucrose preference and intake in mice increased in proportion to stepwise increases in sucrose concentrations. Moreover, sucros...
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#1Jemma Rezitis (Garvan Institute of Medical Research)
#2Herbert Herzog (UNSW: University of New South Wales)H-Index: 79
Last. Chi Kin Ip (UNSW: University of New South Wales)H-Index: 6
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Independent from homeostatic needs, the consumption of foods originating from hyperpalatable diets is defined as hedonic eating. Hedonic eating can be observed in many forms of eating phenotypes, such as compulsive eating and stress-eating, heightening the risk of obesity development. For instance, stress can trigger the consumption of palatable foods as a type of coping strategy, which can become compulsive, particularly when developed as a habit. Although eating for pleasure is observed in mul...
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#1Laura Fusar-Poli (University of Catania)H-Index: 11
#2Lotta-Katrin Pries (Maastricht University Medical Centre)H-Index: 12
Last. Berna Binnur Akdede (Dokuz Eylül University)H-Index: 16
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Abstract null null Background null Social cognition impairments, such as facial emotion recognition (FER), have been acknowledged since the earliest description of schizophrenia. Here, we tested FER as an intermediate phenotype for psychosis using two approaches that are indicators of genetic risk for schizophrenia: the proxy-genetic risk approach (family design) and the polygenic risk score for schizophrenia (PRS-SCZ). null null null Methods null The sample comprised 2039 individuals with schiz...
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#1Guanlong Guo (SWU: Southwest University)
#2Jiaxin Tang (SWU: Southwest University)
Last. Weihai Chen (SWU: Southwest University)H-Index: 2
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Abstract null null Prepulse inhibition (PPI) is disrupted in many neuropsychiatric diseases. Molecules such as 5-HT2C receptor agonists alleviate PPI deficits in rodents; however, the precise mechanisms and critical regions of the brain responsible for the reversal effect of these agonists remain inconclusive. The present study aimed to investigate the areas of the brain critical for the reversal effect of 5-HT2C receptor agonists on PPI deficits in mice. The results showed that systemic adminis...
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#1Irving Remy (French Institute of Health and Medical Research)
#2Thomas SchwitzerH-Index: 11
Last. Vincent LaprevoteH-Index: 16
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Abstract null null Regular cannabis using causes vision impairment by affecting human retinal neurotransmission. However, studies less considered its impact on the subsequent visual cortical processing, key feature for the integration of the visual signal in brain. We aimed at investigating this purpose in regular cannabis users using spatial frequencies and temporal frequencies filtered visual stimuli. null We recruited 45 regular cannabis users and 25 age-matched controls. We recorded visual e...
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#1Jonathan J. Simone (Brock University)H-Index: 8
#2Matthew R Green (CCC: Cameron International)
Last. Cheryl M. McCormick (Brock University)H-Index: 56
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With an increasing number of countries and states adopting legislation permitting the use of cannabis for medical purposes, there is a growing interest among health and research professionals into the system through which cannabinoids principally act, the endocannabinoid system (ECS). Much of the seminal research into the ECS dates back only 30 years and, although there has been tremendous development within the field during this time, many questions remain. More recently, investigations have em...
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#1Yu Luo (Beihang University)
#2C. Chen (ICSCI: Kennedy Krieger Institute)
Last. Joshua B. Ewen (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 16
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Abstract null null Mirror overflow is involuntary movement that accompanies unilateral voluntary movement on the opposite side of the body, and is commonly seen in Attention-Deficit/Hyperactivity Disorder (ADHD). Children with ADHD show asymmetry in mirror overflow between dominant and non-dominant hand, yet there are competing mechanistic accounts of why this occurs. Using EEG during a sequential, unimanual finger-tapping task, we found that children with ADHD exhibited significantly more mirro...
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#1Hongbao Cao (GMU: George Mason University)H-Index: 16
#2Jun Wang (Nanjing Medical University)H-Index: 19
Last. Fuquan Zhang (Nanjing Medical University)H-Index: 19
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Typically, mental disorders are defined and classified based on clinical symptoms and syndromes. Although clinically useful, current diagnostic systems for psychiatry cause concerns due to the lack of biological mechanisms. Deciphering the relationships among psychiatric traits according to their genetic basis may facilitate understanding the biological mechanisms of psychiatric disorders. Ten mental disorders were classified by genomic structural equation modeling (SEM), which leverages summary...
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#1Karl Bosque‐Cordero (UPR-RP: University of Puerto Rico, Río Piedras)
Last. Carlos A. Jiménez-Rivera (University of Puerto Rico, Medical Sciences Campus)H-Index: 12
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Abstract null null The hyperpolarization-activated cation current (Ih) is a determinant of intrinsic excitability in various cells, including dopaminergic neurons (DA) of the ventral tegmental area (VTA). In contrast to other cellular conductances, Ih is activated by hyperpolarization negative to -55 mV and activating Ih produces a time-dependent depolarizing current. Our laboratory demonstrated that cocaine sensitization, a chronic cocaine behavioral model, significantly reduces Ih amplitude in...
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