Journal of Translational Medicine
Papers 4,857
1 page of 486 pages (4,857 results)
#1Eliane F. E. Wenstedt (UvA: University of Amsterdam)H-Index: 3
#2Jetta J. Oppelaar (UvA: University of Amsterdam)H-Index: 1
Last. Liffert Vogt (UvA: University of Amsterdam)H-Index: 24
view all 10 authors...
BACKGROUND By binding to negatively charged polysaccharides called glycosaminoglycans, sodium can be stored in the body-particularly in the skin-without concurrent water retention. Concordantly, individuals with changed glycosaminoglycan structure (e.g. type 1 diabetes (DM1) and hereditary multiple exostosis (HME) patients) may have altered sodium and water homeostasis. METHODS We investigated responses to acute (30-min infusion) and chronic (1-week diet) sodium loading in 8 DM1 patients and 7 H...
#1Ling Li (CAMS&PUMC: Chinese Academy of Medical Sciences & Peking Union Medical College)H-Index: 19
#2Chianru Tan (THU: Tsinghua University)H-Index: 6
Last. Zhong Liu (CAMS&PUMC: Chinese Academy of Medical Sciences & Peking Union Medical College)H-Index: 12
view all 18 authors...
Background COVID-19 has caused a global pandemic and the death toll is increasing. However, there is no definitive information regarding the type of clinical specimens that is the best for SARS-CoV-2 detection, the antibody levels in patients with different duration of disease, and the relationship between antibody level and viral load. Methods Nasopharyngeal swabs, anal swabs, saliva, blood, and urine specimens were collected from patients with a course of disease ranging from 7 to 69 days. Vir...
#1Takeshi Nakata (Oita University)H-Index: 3
#2Takashi Ariie (IUHW: International University of Health and Welfare)H-Index: 2
Last. Shunsuke TaitoH-Index: 7
view all 3 authors...
#1Qing-Song Jin (Binzhou University)H-Index: 3
#2Liang-Yan Lin (Binzhou University)H-Index: 2
Last. Meizi Yang (Binzhou University)
view all 8 authors...
BACKGROUND Diabetes mellitus (DM), a most common chronic disease, is featured with impaired endothelial function and bioavailability of nitric oxide (NO), while E3 ubiquitin ligase appears to alleviate endothelial dysfunction as a promising option for DM treatment. Herein, we aimed to determine whether E3 ubiquitin ligase casitas B-lineage lymphoma (Cbl) alleviates endothelial dysfunction in DM rats by JAK2/STAT4 pathway. METHODS A rat model of DM was developed through intraperitoneal injection ...
#1Shuang Li (HMU: Harbin Medical University)H-Index: 4
#2Xu Wang (HMU: Harbin Medical University)
Last. Si Xu (HMU: Harbin Medical University)H-Index: 2
view all 13 authors...
BACKGROUND Long non-coding RNAs (lncRNAs), functioning as competing endogenous RNAs (ceRNAs), have been reported to play important roles in the pathogenesis of autoimmune diseases. However, little is known about the regulatory roles of lncRNAs underlying the mechanism of myasthenia gravis (MG). The aim of the present study was to explore the roles of lncRNAs as ceRNAs associated with the progression of MG. METHODS MG risk genes and miRNAs were obtained from public databases. Protein-protein inte...
#1Tai Yin (Feinstein Institute for Medical Research)
#2Lance B Becker (Hofstra University)H-Index: 31
Last. Shuhei EguchiH-Index: 1
view all 21 authors...
Background null Despite the benefits of extracorporeal cardiopulmonary resuscitation (ECPR) in cohorts of selected patients with cardiac arrest (CA), extracorporeal membrane oxygenation (ECMO) includes an artificial oxygenation membrane and circuits that contact the circulating blood and induce excessive oxidative stress and inflammatory responses, resulting in coagulopathy and endothelial cell damage. There is currently no pharmacological treatment that has been proven to improve outcomes after...
#1Tianming Le (CSU: Central South University)
#2Xin He (CSU: Central South University)
Last. Kemin Wu (CSU: Central South University)
view all 6 authors...
Background null Abdominal aortic aneurysm (AAA), an irreversible cardiovascular disease prevalent in the artery, causes the increase of the aneurysm diameter over time, and is a fatal phenomenon inducing sidewall rupture. Long noncoding RNAs (lncRNAs) serve as promising biomarkers for AAA. In the present study, we sought to define the role of lncRNA growth-arrest-specific transcript 5 (GAS5) in growth of smooth muscle cells (SMC) and progression of AAA. null Methods null Initially, we establishe...
#2Yueting Li (CMU: China Medical University)
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Background null Osteosarcoma is a common type of bone tumors and frequently occurs in children and adolescents. Cancer stem cells (CSCs) are a unique sub-type of self-renewal cancer cells and the stemness of cancer cells are involved in the spread, recurrence, metastasis, and even therapeutic resistance. However, the regulation mechanisms of CSCs in osteosarcoma are poorly understood. Circular RNA (circRNA) is a unique sort of non-coding RNAs and widely participate in the modulation of cancer pr...
#1Qin Zhang (NCU: Nanchang University)H-Index: 4
#2Xiao-Ming Liu (NCU: Nanchang University)H-Index: 1
Last. Xue-Kang Zhang (NCU: Nanchang University)H-Index: 5
view all 10 authors...
BACKGROUND Intestinal ischemia/reperfusion (I/R) injury commonly occurs during perioperative periods, resulting in high morbidity and mortality on a global scale. Dexmedetomidine (Dex) is a selective α2-agonist that is frequently applied during perioperative periods for its analgesia effect; however, its ability to provide protection against intestinal I/R injury and underlying molecular mechanisms remain unclear. METHODS To fill this gap, the protection of Dex against I/R injury was examined in...
#1Jordana Kron (Virginia Commonwealth University Medical Center)H-Index: 14
#2Thomas Crawford (UM: University of Michigan–Ann Arbor)H-Index: 41
Last. Kelly Polly (VCU: Virginia Commonwealth University)H-Index: 1
view all 24 authors...
Background null Sarcoidosis is an inflammatory disease characterized by the formation of granulomas, which involve the heart in up to 25% of patients. Cardiac sarcoidosis can lead to life threatening arrhythmias and heart failure. While corticosteroids have been used as a treatment for over 50 years, they are associated with hypertension, diabetes, and weight gain, further increasing cardiovascular risk. Interleukin-1 (IL-1) is the prototypical proinflammatory cytokine that works to activate the...
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