Journal of Translational Medicine
Papers 4672
1 page of 468 pages (4,672 results)
#1Rui Zhao (Fudan University)
#2Ying Wang (Fudan University)
Last. Zhe Ruan (Fourth Military Medical University)
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BACKGROUND An accurate prediction for prognosis can help in guiding the therapeutic options and optimizing the trial design for generalized myasthenia gravis (gMG). We aimed to develop and validate a predictive nomogram to assess the short-term outcome in patients with the anti-acetylcholine receptor (AChR) subtype gMG. METHODS We retrospectively reviewed 165 patients with AChR subtype gMG who were immunotherapy naive at the first visit from five tertiary centers in China. The short-term clinica...
#1Jing-Qiang Huang (SZU: Shenzhen University)H-Index: 1
#2He-Feng Li (SZU: Shenzhen University)H-Index: 1
Last. Li-Yun Gong (SZU: Shenzhen University)H-Index: 8
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BACKGROUND Colorectal cancer is the third most common diagnosis. Oxaliplatin is used as first-line treatment of colon cancer. However, oxaliplatin resistance greatly reduces its therapeutic effect. SRPK1 involves in pre-mRNA splicing and tumorigenesis. How SRPK1 mediates drug resistance in colon cancer is unknown. METHODS The expression of SRPK1 was analyzed in the TCGA and the CPTAC pan-cancer samples and detected in colon cancer cell lines and tissues by IHC and western blot. The MTT and TUNEL...
#1Xiaoxiao Yang (Fudan University)
#2Manchen BaoH-Index: 1
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BACKGROUND Epithelial-mesenchymal transition (EMT) of mesothelial cells is a key step in the peritoneal fibrosis (PF). Recent evidence indicates that signal transducer and activator of transcription 3 (STAT3) might mediate the process of renal fibrosis, which could induce the expression of hypoxia-inducible factor-1α (HIF-1α). Here, we investigated the effect of STAT3 activation on HIF-1α expression and the EMT of mesothelial cells, furthermore the role of pharmacological blockade of STAT3 in th...
#1Dagui Lin (SYSU: Sun Yat-sen University)
#2Wenhua Fan (SYSU: Sun Yat-sen University)H-Index: 5
Last. Liren Li (SYSU: Sun Yat-sen University)H-Index: 7
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BACKGROUND Metabolic reprograming have been associated with cancer occurrence and progression within the tumor immune microenvironment. However, the prognostic potential of metabolism-related genes in colorectal cancer (CRC) has not been comprehensively studied. Here, we investigated metabolic transcript-related CRC subtypes and relevant immune landscapes, and developed a metabolic risk score (MRS) for survival prediction. METHODS Metabolism-related genes were collected from the Molecular Signat...
#1Chun Zhou (Southern Medical University)H-Index: 5
#2Yuanyuan Zhang (Southern Medical University)H-Index: 13
Last. Jianwei Tian (Southern Medical University)H-Index: 14
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BACKGROUND The association between serum advanced oxidation protein products (AOPP) and mortality risk remains equivocal. We aimed to assess the correlation of serum AOPP levels with the risk of all-cause mortality in hemodialysis (HD) patients. METHODS A total of 1394 maintenance HD patients with complete data on AOPP and related parameters were included from China Collaborative Study on Dialysis (CCSD), a multi-center, prospective cohort study. The primary outcome was all-cause mortality, the ...
#1Xiawei Li (ZJU: Zhejiang University)
#2Litao Yang (CAS: Chinese Academy of Sciences)
Last. Yulian Wu (ZJU: Zhejiang University)
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Background null Surgical resection is the only potentially curative treatment for pancreatic ductal adenocarcinoma (PDAC) and the survival of patients after radical resection is closely related to relapse. We aimed to develop models to predict the risk of relapse using machine learning methods based on multiple clinical parameters. null Methods null Data were collected and analysed of 262 PDAC patients who underwent radical resection at 3 institutions between 2013 and 2017, with 183 from one ins...
#1Takeshi Nakata (Oita University)H-Index: 3
#2Takashi Ariie (International University of Health and Welfare)H-Index: 2
Last. Shunsuke TaitoH-Index: 5
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#1Paolo A. AsciertoH-Index: 91
#2Christian U. Blank (NKI-AVL: Netherlands Cancer Institute)H-Index: 73
Last. P. Kalinski (Roswell Park Cancer Institute)
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Advances in immune checkpoint therapy and targeted therapy have led to improvement in overall survival for patients with advanced melanoma. Single agent checkpoint PD-1 blockade and combination with BRAF/MEK targeted therapy demonstrated benefit in overall survival (OS). Superior response rates have been demonstrated with combined PD-1/CTLA-4 blockade, with a significant OS benefit compared with single-agent PD-1 blockade. Despite the progress in diagnosis of melanocytic lesions, correct classif...
#1Noura M. AlOtaibi (Glas.: University of Glasgow)
#2Michael Dunne (Glas.: University of Glasgow)
Last. K. Naudi (Glas.: University of Glasgow)H-Index: 8
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Background: Dental implants are considered the gold standard replacement for missing natural teeth. The successful clinical performance of dental implants is due to their ability to osseointegrate with the surrounding bone. Most dental implants are manufactured from Titanium and it alloys. Titanium does however have some shortcomings so alternative materials are frequently being investigated. Effective preclinical studies are essential to transfer the innovations from the benchtop to the patient...
#1Yuanyuan Yao (ZJU: Zhejiang University)H-Index: 1
#2Jenny Cifuentes (La Salle University, Colombia)H-Index: 4
Last. Min Yan (ZJU: Zhejiang University)H-Index: 1
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Top fields of study
Cancer research
Diabetes mellitus
Immune system