Annals of Biomedical Engineering
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#1Tim Wang (UBC: University of British Columbia)H-Index: 3
#2Rebecca A Kenny (UBC: University of British Columbia)H-Index: 1
Last. Lyndia C. Wu (UBC: University of British Columbia)H-Index: 14
view all 3 authors...
Contact sports players frequently sustain head impacts, most of which are mild impacts exhibiting 10-30 g peak head center-of-gravity (CG) linear acceleration. Wearable head impact sensors are commonly used to measure exposure and typically detect impacts using a linear acceleration threshold. However, linear acceleration across the head can substantially vary during 6-degree-of-freedom motion, leading to triggering biases that depend on sensor location and impact condition. We conducted an anal...
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#1Cyril Tous (UdeM: Université de Montréal)
#2Ning Li (UdeM: Université de Montréal)
Last. Marcus J Couch (Siemens)
view all 13 authors...
Magnetic resonance navigation (MRN) uses MRI gradients to steer magnetic drug-eluting beads (MDEBs) across vascular bifurcations. We aim to experimentally verify our theoretical forces balance model (gravitational, thrust, friction, buoyant and gradient steering forces) to improve the MRN targeted success rate. A single-bifurcation phantom (3 mm inner diameter) made of poly-vinyl alcohol was connected to a cardiac pump at 0.8 mL/s, 60 beats/minutes with a glycerol solution to reproduce the visco...
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#1Daiki Tanaka (Tokyo Medical and Dental University)H-Index: 1
#2Yuichi Ikeda (Tokyo Medical and Dental University)H-Index: 5
Last. Takanori Iwata (Tokyo Medical and Dental University)H-Index: 26
view all 6 authors...
Amelotin (AMTN) is a protein that is expressed during the maturation of dental enamel and has important role in enamel hydroxyapatite mineralization. However, it is not well understood whether AMTN has a strong mineral-promoting ability in bone. In this study, the effect of AMTN on bone healing was investigated using mice calvarial defect model in vivo, and the expression of bone marker genes and cell proliferation were investigated to clarify the role of AMTN in bone mineralization using mouse ...
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#1Mehrsa Mehrabi (UCI: University of California, Irvine)H-Index: 2
#2Tessa Altair Morris (UCI: University of California, Irvine)H-Index: 1
Last. Qing Nie (UCI: University of California, Irvine)H-Index: 39
view all 12 authors...
Genetic mutations to the Lamin A/C gene (LMNA) can cause heart disease, but the mechanisms making cardiac tissues uniquely vulnerable to the mutations remain largely unknown. Further, patients with LMNA mutations have highly variable presentation of heart disease progression and type. In vitro patient-specific experiments could provide a powerful platform for studying this phenomenon, but the use of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) introduces heterogeneity in maturi...
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#1Jed A. Diekfuss (Emory University)H-Index: 10
#2Weihong Yuan (Cincinnati Children's Hospital Medical Center)H-Index: 21
Last. Joseph F. Clark (University of Cincinnati Academic Health Center)H-Index: 34
view all 18 authors...
We aimed to objectively compare the effects of wearing newer, higher-ranked football helmets (HRank) vs. wearing older, lower-ranked helmets (LRank) on pre- to post-season alterations to neuroimaging-derived metrics of athletes' white matter. Fifty-four high-school athletes wore an HRank helmet, and 62 athletes wore an LRank helmet during their competitive football season and completed pre- and post-season diffusion tensor imaging (DTI). Longitudinal within- and between-group DTI metrics [fracti...
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#1J.L. Bramley (University of Southampton)H-Index: 1
#2Peter Worsley (RMIT: RMIT University)H-Index: 15
Last. Alexander Dickinson (University of Southampton)H-Index: 11
view all 7 authors...
Despite the potential for biomechanical conditioning with prosthetic use, the soft tissues of residual limbs following lower-limb amputation are vulnerable to damage. Imaging studies revealing morphological changes in these soft tissues have not distinguished between superficial and intramuscular adipose distribution, despite the recognition that intramuscular fat levels indicate reduced tolerance to mechanical loading. Furthermore, it is unclear how these changes may alter tissue tone and stiff...
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#1Suraj K. Puvvada (Wake Forest University)
#2Elizabeth M. Davenport (UTSW: University of Texas Southwestern Medical Center)H-Index: 11
Last. Jillian E. Urban (Wake Forest University)H-Index: 16
view all 9 authors...
Approximately 3.5 million youth and adolescents in the US play football, a sport with one of the highest rates of concussion. Repeated subconcussive head impact exposure (HIE) may lead to negative neurological sequelae. To understand HIE as an independent predictive variable, quantitative cumulative kinematic metrics have been developed to capture the volume (i.e., number), severity (i.e., magnitude), and frequency (i.e., time-weighting by the interval between head impacts). In this study, time-...
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#1Clemens ZeileH-Index: 4
#2Thomas RauwolfH-Index: 6
Last. Sebastian SagerH-Index: 22
view all 6 authors...
A promising treatment for congestive heart failure is the implementation of a left ventricular assist device (LVAD) that works as a mechanical pump. Modern LVADs work with adjustable constant rotor speed and provide therefore continuous blood flow; however, recently undertaken efforts try to mimic pulsatile blood flow by oscillating the pump speed. This work proposes an algorithmic framework to construct and evaluate optimal pump speed policies with respect to generic objectives. We use a model ...
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#1Nicholas J. Cecchi (Stanford University)H-Index: 3
#2August G. Domel (Stanford University)H-Index: 10
Last. Heer Singh (Stanford University)H-Index: 1
view all 16 authors...
Repeated head impact exposure and concussions are common in American football. Identifying the factors associated with high magnitude impacts aids in informing sport policy changes, improvements to protective equipment, and better understanding of the brain's response to mechanical loading. Recently, the Stanford Instrumented Mouthguard (MiG2.0) has seen several improvements in its accuracy in measuring head kinematics and its ability to correctly differentiate between true head impact events an...
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#1Ann R. Harlos (VT: Virginia Tech)
#2Steven Rowson (VT: Virginia Tech)H-Index: 28
The best way to prevent severe head injury when cycling is to wear a bike helmet. To reduce the rate of head injury in cycling, knowing the nature of real-world head impacts is crucial. Reverse engineering real-world bike helmet impacts in a laboratory setting is an alternative to measuring head impacts directly. This study aims to quantify bike helmet damage using computed tomography (CT) and reconstruct real-world damage with a custom, oblique test rig to recreate real-world impacts. Damaged h...
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