Alzheimer's Research & Therapy
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#1Julia StockmannH-Index: 2
#2Inge M.W. VerberkH-Index: 7
Last. Klaus GerwertH-Index: 64
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Following publication of the original article [1], the authors noticed that the published figures have errors which was occurred during processing of the figures in production team. 1) fonts are shifted (Figure 1) 2) colors are not displayed (Figure 2, open circles should be colored) 3) labelling is incorrect (Figure 4, "Afl" should be "As", Supplementary Figures "D Absorbance" should be "? absorbance" (Δ = delta)) The correct Figures 1, 2 and 4 are shown below. The original article [1] has been...
#1Gemma Ortega (ISCIII: Carlos III Health Institute)H-Index: 12
#2Ana Espinosa (ISCIII: Carlos III Health Institute)H-Index: 6
Last. Assumpta VivasH-Index: 4
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Background null To explore whether the combination of white matter hyperintensities (WMHs) and amyloid-beta (Aβ) deposition is associated with worse cognitive performance on cognitive composites (CCs) domain scores in individuals with subjective cognitive decline (SCD). null Methods null Two hundred participants from the FACEHBI cohort underwent structural magnetic resonance imaging (MRI), 18F-florbetaben positron emission tomography (FBB-PET), and neuropsychological assessment. WMHs were addres...
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#1Alex I. Wiesman (Montreal Neurological Institute and Hospital)
#2Daniel L. Murman (UNMC: University of Nebraska Medical Center)H-Index: 13
Last. Tony W. Wilson (Boys Town)H-Index: 30
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BACKGROUND Entrainment of neural oscillations in occipital cortices by external rhythmic visual stimuli has been proposed as a novel therapy for patients with Alzheimer's disease (AD). Despite this increased interest in visual neural oscillations in AD, little is known regarding their role in AD-related cognitive impairment and in particular during visuospatial processing. METHODS We used source-imaged magnetoencephalography (MEG) and an established visuospatial processing task to elicit multi-s...
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#1Wiesje Pelkmans (VU: VU University Amsterdam)H-Index: 3
#2Rik Ossenkoppele (Lund University)H-Index: 42
Last. Oskar Hansson (Lund University)H-Index: 92
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BACKGROUND Changes in grey matter covariance networks have been reported in preclinical and clinical stages of Alzheimer's disease (AD) and have been associated with amyloid-β (Aβ) deposition and cognitive decline. However, the role of tau pathology on grey matter networks remains unclear. Based on previously reported associations between tau pathology, synaptic density and brain structural measures, tau-related connectivity changes across different stages of AD might be expected. We aimed to as...
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#1Michael L. Alosco (BU: Boston University)H-Index: 36
#2Megan L Mariani (BU: Boston University)H-Index: 1
Last. Robert C. Cantu (BU: Boston University)H-Index: 89
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BACKGROUND Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that has been neuropathologically diagnosed in brain donors exposed to repetitive head impacts, including boxers and American football, soccer, ice hockey, and rugby players. CTE cannot yet be diagnosed during life. In December 2015, the National Institute of Neurological Disorders and Stroke awarded a seven-year grant (U01NS093334) to fund the "Diagnostics, Imaging, and Genetics Network for the Objective Study and ...
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#1Davina Biel (LMU: Ludwig Maximilian University of Munich)
#1Davina Biel (LMU: Ludwig Maximilian University of Munich)
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BACKGROUND To systematically examine the clinical utility of tau-PET and Braak-staging as prognostic markers of future cognitive decline in older adults with and without cognitive impairment. METHODS In this longitudinal study, we included 396 cognitively normal to dementia subjects with 18F-Florbetapir/18F-Florbetaben-amyloid-PET, 18F-Flortaucipir-tau-PET and ~ 2-year cognitive follow-up. Annual change rates in global cognition (i.e., MMSE, ADAS13) and episodic memory were calculated via linear...
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BACKGROUND Perivascular spaces (PVS) have an important role in the elimination of metabolic waste from the brain. It has been hypothesized that the enlargement of PVS (ePVS) could be affected by pathophysiological mechanisms involved in Alzheimer's disease (AD), such as abnormal levels of CSF biomarkers. However, the relationship between ePVS and these pathophysiological mechanisms remains unknown. OBJECTIVE We aimed to investigate the association between ePVS and CSF biomarkers of several patho...
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#1Marta Milà-AlomàH-Index: 3
#2Mahnaz Shekari (UPF: Pompeu Fabra University)
Last. Aleix Sala-Vila (Wellington Management Company)
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BACKGROUND Understanding the changes that occur in the transitional stage between absent and overt amyloid-β (Aβ) pathology within the Alzheimer's continuum is crucial to develop therapeutic and preventive strategies. The objective of this study is to test whether cognitively unimpaired individuals with a low burden of Aβ pathology have a distinct CSF, structural, and functional neuroimaging biomarker profile. METHODS Cross-sectional study of 318 middle-aged, cognitively unimpaired individuals f...
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#2Philip ScheltensH-Index: 155
Last. Wiesje M. van der FlierH-Index: 90
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#1Samantha Prins (LUMC: Leiden University Medical Center)H-Index: 3
#2Ahnjili ZhuparrisH-Index: 1
Last. Geert Jan Groeneveld (LUMC: Leiden University Medical Center)H-Index: 5
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BACKGROUND In the current study, we aimed to develop an algorithm based on biomarkers obtained through non- or minimally invasive procedures to identify healthy elderly subjects who have an increased risk of abnormal cerebrospinal fluid (CSF) amyloid beta42 (Aβ) levels consistent with the presence of Alzheimer's disease (AD) pathology. The use of the algorithm may help to identify subjects with preclinical AD who are eligible for potential participation in trials with disease modifying compounds...
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