Archives of Pathology & Laboratory Medicine
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#1Timothy Craig AllenH-Index: 20
#2Patrick O. Smith (UMMC: University of Mississippi Medical Center)H-Index: 5
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CONTEXT.— Acquiring objective, timely, and comprehensive feedback on resident diagnostic performance is notoriously difficult. OBJECTIVE.— To implement a custom software application (Resident Case Tracker) to improve evaluative diagnostic analysis for residency programs. DESIGN.— Residents and faculty use a graphical user interface with restricted access to their own cases and evaluations. For each sign-out, residents enter their diagnoses and comments for each case. Faculty are provided a sign-...
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#1Valentina Nardi (Harvard University)H-Index: 26
#2Karen D. Tsuchiya (Seattle Children's)H-Index: 1
Last. Ann M Moyer (UR: University of Rochester)
view all 11 authors...
Context.— null Next-generation sequencing-based assays are increasingly used in clinical molecular laboratories to detect somatic variants in solid tumors and hematologic malignancies and to detect constitutional variants. Proficiency testing data are potential sources of information about challenges in performing these assays. null Objective.— null To examine the most common sources of unacceptable results from the College of American Pathologists Next-Generation Sequencing Bioinformatics, Hema...
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CONTEXT.— Precision therapies for patients with driver mutations can offer deep and durable responses that correlate with diagnosis, metastasis prognosis, and improvement in survival. Such targeted therapies will continue to increase, pushing us to change our traditional approaches. We needed to search for new tools to effectively integrate technological advancements into our practices because of their capability to improve the efficiency and accuracy of our diagnostic and treatment approaches. ...
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#1Scott C. Bresler (UM: University of Michigan)H-Index: 1
#2Caroline T. Simon (UM: University of Michigan)H-Index: 4
Last. Rajiv M. Patel (UM: University of Michigan)H-Index: 29
view all 6 authors...
CONTEXT.— Conjunctival melanocytic lesions consist of a variety of neoplastic and nonneoplastic conditions. These include benign processes such as primary intraepithelial hypermelanosis and melanocytic hyperplasia, secondary forms of intraepithelial hypermelanosis and melanocytic hyperplasia, melanocytic nevi, melanocytic proliferations with malignant potential, and melanoma. OBJECTIVE.— To provide a concise yet comprehensive resource regarding the histopathologic diagnosis of conjunctival melan...
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CONTEXT: - In the face of the coronavirus disease 2019 (COVID-19) pandemic response, it was worthwhile to test the safety and efficacy of COVID-19 convalescent plasma (CCP) transfusion. OBJECTIVE: - To establish a CCP donation program based on the availability of recovered COVID-19 patients and the practical limitations to recruit clinically valid donors in a multicultural setting. DESIGN: - From March to June 2020, we developed a program for collection of COVID-19 CCP as part of the treatment o...
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#1Feras Zaiem (WSU: Wayne State University)H-Index: 11
#2Hany Deirawan (WSU: Wayne State University)H-Index: 2
Last. Rouba Ali-Fehmi (WSU: Wayne State University)H-Index: 34
view all 8 authors...
CONTEXT.— Intraoperative consultation-frozen section diagnosis (FSD)-determines tumor pathology and guides the optimal surgical management of ovarian neoplasms intraoperatively. OBJECTIVE.— To evaluate the diagnostic accuracy of the FSD and analyze the discrepancy between the FSD and final diagnosis. DESIGN.— This is a retrospective study of 618 ovarian neoplasm FSDs from 2009 to 2018 at a tertiary health care center. The discrepant cases were reviewed and reevaluated by gynecologic and general ...
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#1Huihong Xu (BU: Boston University)
#2Fang Fan (KU: University of Kansas)H-Index: 20
Last. Zaibo Li (The Ohio State University Wexner Medical Center)H-Index: 23
view all 8 authors...
Context.— null Mediastinal tumors/lesions are frequently encountered in daily cytopathology practice. These lesions are accessible through endoscopic/endobronchial ultrasound-guided or computed tomography-guided fine-needle aspiration cytology and represent a wide range of primary and metastatic tumors. This often poses diagnostic challenges because of the complexity of the mediastinal anatomic structures. Tumors metastatic to mediastinal lymph nodes represent the most common mediastinal lesions...
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#1David F. Keren (UM: University of Michigan)H-Index: 22
#2Gregary Bocsi (CU: University of Colorado Boulder)
Last. David L. MurrayH-Index: 26
view all 15 authors...
CONTEXT.— The process for identifying patients with monoclonal gammopathies is complex. Initial detection of a monoclonal immunoglobulin protein (M protein) in the serum or urine often requires compilation of analytical data from several areas of the laboratory. The detection of M proteins depends on adequacy of the sample provided, available clinical information, and the laboratory tests used. OBJECTIVE.— To develop an evidence-based guideline for the initial laboratory detection of M proteins....
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CONTEXT.— Measurable (minimal) residual disease (MRD) is an independent prognostic factor for survival outcomes in patients with lymphoid and plasma cell malignancies and has been incorporated into consensus criteria regarding treatment response, strategy, and clinical trial endpoints. clonoSEQ (a next-generation sequencing [NGS]-MRD assay) uses multiplex polymerase chain reaction and NGS to identify clonotypic rearrangements at the immunoglobulin (Ig) H, IgK, IgL, T-cell receptor (TCR)-β, and T...
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