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#1Kim ThomsenH-Index: 11
#2Henrik PedersenH-Index: 14
Last. Xiaohui Chen NielsenH-Index: 10
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BACKGROUND: Microbial co-infections may contribute to the pulmonary deterioration in COVID-19 patients needing intensive care treatment. The present study portray the extent of co-infections in COVID-19 ICU patients. METHODS: Conventional culture, molecular detections for atypical aetiologies, QiaStat-Dx® respiratory panel V2 detecting 21 respiratory pathogens and ribosomal DNA genes 16S/18S amplicon-based microbiome analyses were performed on respiratory samples from 34 COVID-19 patients admitt...
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#1Valtteri Kairaluoma (OUH: Oulu University Hospital)H-Index: 1
#2Niko Kemi (OUH: Oulu University Hospital)H-Index: 3
Last. Olli Helminen (OUH: Oulu University Hospital)H-Index: 11
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BACKGROUND Toll-like receptors (TLRs) are components of innate immunity, but also have a role in carcinogenesis. The prognostic value of TLR5 and TLR8 tumor expression was examined in contrast with known risk markers Ki67 and p53. METHODS All HCC patients from Oulu University Hospital with available representative tumor sample were included in this study (n=182). TLR5, TLR8, Ki67 and p53 expression were investigated by immunohistochemistry. The relation between patient survival and TLR, Ki67 and...
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#1Muhammad Asif (King Edward Medical University)H-Index: 46
#2Hafsa Naseem (University of the Punjab)
Last. Shafiq‐ur‐Rehman (University of the Punjab)
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Enterobacter cloacae (E. cloacae) is an emerging nosocomial pathogen that had acquired antibiotic resistance against multiple classes of antibiotics. The current study was aimed to isolate and characterize lytic bacteriophage against E. cloacae. The bacteriophage EBP was isolated from a sewage water sample using E. cloacae as a host strain by double-layer agar technique. EBP was found stabile at a wide range of temperatures (25, 37, 60 and 80°C) and pH (5, 6, 7, 8, and 9) with antibacterial acti...
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#1ML Mikkelsen (OUH: Odense University Hospital)
#2Niels Marcussen (OUH: Odense University Hospital)H-Index: 35
Last. Maj Rabjerg (OUH: Odense University Hospital)H-Index: 7
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BACKGROUND AND PURPOSE The increasing demands for personalized targeted therapy directed against Renal Cell Carcinoma has driven a search for predictive markers. Novel therapies targeting HIF-1α in Renal Cell Carcinoma have been developed and HIF-1α has been suggested as a novel predictive marker of response to therapy. The surgical resection of a kidney tumor induces tissue ischemia and HIF-1α is an oxygen-sensitive transcription factor, which is known to be up-regulated during hypoxia. MATERIA...
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#1Kristian Schønning (Copenhagen University Hospital)H-Index: 6
Last. Marianne Voldstedlund (SSI: Statens Serum Institut)H-Index: 11
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The COVID-19 pandemic has led to an unprecedented demand for real-time surveillance data in order to inform critical decision makers regarding the management of the pandemic. The aim of this review is to describe how the Danish national microbiology database, MiBa, served as a cornerstone for providing data to the real-time survelliance system by linkage to other nationwide health registries. The surveillance system was established on an existing IT health infrastructure and a close network betw...
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#1Søren Ørskov (RU: Roskilde University)
#2Bjarke Frost Nielsen (UCPH: University of Copenhagen)H-Index: 3
Last. Lone Simonsen (RU: Roskilde University)H-Index: 68
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The response to the ongoing COVID-19 pandemic has been characterized by draconian measures and far too many important unknowns, such as the true mortality risk, the role of children as transmitters and the development and duration of immunity in the population. More than a year into the pandemic much has been learned and insights into this novel type of pandemic and options for control are shaping up. Using a historical lens, we review what we know and still do not know about the ongoing COVID-1...
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#1Jonas Wetterö (Linköping University)H-Index: 20
#2Frida Jönsson (Linköping University)
Last. Christopher Sjöwall (Linköping University)H-Index: 27
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Background Pentraxin-3 (PTX3) is a conserved protein of the innate immune system which has been less studied than the pentraxin C-reactive protein (CRP), but it is of relevance in e.g., vascular pathology and pregnancy morbidities. Since the interest in salivary biomarkers in general is increasing, we asked whether PTX3 could be detected in saliva and if any substantial diurnal variation occurs. In addition, we evaluated association with biomarkers of systemic inflammation (interleukin (IL)-1β, ...
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#1Khaled Ghathian (UCPH: University of Copenhagen)
#2Niels Frimodt-Møller (UCPH: University of Copenhagen)H-Index: 50
Staphylococcus aureus and beta-hemolytic streptococci of groups A, C or G are the most common pathogens in skin infections e.g. erysipelas (1). Co-infection of these beta-hemolytic streptococci with S. aureus is often treated with the combination of penicillin and an isoxazoyl penicillin (2). Single treatment with an isoxazoyl penicillin would be easier and save antibiotics if there was sufficient activity against the beta-hemolytic streptococci groups A, C and G.
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#1Anita Blomfeldt (Ahus: Akershus University Hospital)H-Index: 8
#2Silje Bakken Jørgensen (Ahus: Akershus University Hospital)H-Index: 10
Last. Hege Vangstein Aamot (Ahus: Akershus University Hospital)H-Index: 7
view all 5 authors...
1 CitationsSource
#1Espen Skarstein Kolberg (NTNU: Norwegian University of Science and Technology)H-Index: 1
#2Kristin E Wickstrøm (Oslo University Hospital)H-Index: 1
Last. Erik K. Amundsen (Oslo University Hospital)H-Index: 3
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We have earlier proposed that serum ACE (s-ACE) could be used as a biomarker for severity in COVID-19 due to an assumed inverse relationship between ACE and ACE2. High s-ACE could indicate lower ACE2 activity and therefore more widespread and severe SARS-CoV2 infection, owing to virally mediated downregulation of ACE2 (1). Dysregulation of the Renin-Angiotensin-Aldosterone system (RAAS) are found in comorbidities known as risk factors for increased morbidity and mortality, such as hypertension a...
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