Annals of Diagnostic Pathology
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#1Gerard J. Nuovo (OSU: Ohio State University)H-Index: 83
#2Cynthia M. Magro (Cornell University)H-Index: 58
Last. Esmerina Tili (OSU: Ohio State University)H-Index: 24
view all 10 authors...
Neurologic complications of symptomatic COVID-19 are common. Brain tissues from 13 autopsies of people who died of COVID-19 were examined. Cultured endothelial and neuronal cells were incubated with and wild type mice were injected IV with different spike subunits. In situ analyses were used to detect SARS-CoV-2 proteins and the host response. In 13/13 brains from fatal COVID-19, pseudovirions (spike, envelope, and membrane proteins without viral RNA) were present in the endothelia of microvesse...
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Abstract Background Oncotype Dx is a 21-gene recurrence score, which is used as a diagnostic tool for the recurrence of breast cancer. It is also used to determine the benefit of chemotherapy for breast cancer in early stages. This study investigates the relationship of Oncotype Dx with pathological prognostic markers of protein Ki 67, Nottingham Prognostic Index (NPI) and tumor grade. Methods Data for early breast cancer patients treated at our tertiary care center was collected for statistical...
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#1Ryan Demkowicz (Cleveland Clinic)H-Index: 1
#2Prashanthi N. ThotaH-Index: 16
Last. Ilyssa GordonH-Index: 7
view all 13 authors...
Abstract Subsquamous intestinal metaplasia (SSIM) in the setting of Barrett's esophagus (BE) is a technically challenging diagnosis. While the risk for progression of BE involving the surface mucosa is well documented, the potential risk for development of advanced neoplasia associated with SSIM has been controversial. This study aimed to determine the effects of specimen adequacy, presence of dysplasia, and interobserver agreement for SSIM interpretation. Adult patients (n = 28) who underwent e...
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#1Aziza E. Abdelrahman (Zagazig University)H-Index: 5
#2Hayam E. Rashed (Zagazig University)H-Index: 5
Last. Ihab MatarH-Index: 1
view all 6 authors...
Abstract Patients with breast cancer are appropriate candidates for neoadjuvant chemotherapy (NAC) to facilitate conservative surgery. The chemotherapeutic agents may exert their action by inducing the anti-tumor immune response. This study aimed to evaluate the tumor immune microenvironment including PD-L1, Foxp3+ Tregs, and TILs count in early stages TNBC patients (stage T1, T2) before and after neoadjuvant chemotherapy and their correlation with the clinical and pathological response. Fifty p...
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#1Julia R. Naso (UBC: University of British Columbia)H-Index: 2
#2Gang WangH-Index: 6
Last. Diana N. IonescuH-Index: 21
view all 8 authors...
Abstract PD-L1 expression in non-small cell lung cancer (NSCLC) is predictive of response to treatment with PD-1 and PD-L1 inhibitors. Different inhibitors have been developed with different PD-L1 assays, which use different PD-1 antibody clones on different immunohistochemistry platforms. Depending on instrument and reagent availability, laboratory-developed tests with cross-platform use of PD-L1 antibodies may have practical benefits over commercial assays. The 22C3 pharmDx Assay (referred to ...
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Abstract Background Estrogen receptors (ER), progesterone receptors (PR) and the human epidermal growth factor receptor-2 (HER2) are basic breast cancer molecular markers that are also best recognized prognostic factors and predictors of type of targeted therapy to be given. The objectives are to study the correlation of expression of hormone and HER2receptors with various clinico-pathological prognostic parameters like patient's age at diagnosis, menopausal status, tumor size, histological grad...
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#1Cristina Díaz del Arco (Complutense University of Madrid)H-Index: 6
#2Lourdes Estrada Muñoz (Complutense University of Madrid)H-Index: 3
Last. Mª Jesús Fernández Aceñero (Hospital General Universitario Gregorio Marañón)H-Index: 2
view all 7 authors...
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#1Daniel D. MaisH-Index: 3
#2Sarah HackmanH-Index: 1
Last. Jenny Ross (University of Texas Health Science Center at San Antonio)
view all 3 authors...
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#1Cynthia M. Magro (Cornell University)H-Index: 58
#2Justin Mulvey (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 1
Last. Gerard J. Nuovo (OSU: Ohio State University)H-Index: 83
view all 8 authors...
The objective of this study was to elucidate the pathophysiology that underlies severe COVID-19 by assessing the histopathology and the in situ detection of infectious SARS-CoV-2 and viral capsid proteins along with the cellular target(s) and host response from twelve autopsies. There were three key findings: 1) high copy infectious virus was limited mostly to the alveolar macrophages and endothelial cells of the septal capillaries; 2) viral spike protein without viral RNA localized to ACE2+ end...
2 CitationsSource
#1Yusuke Kondo (Tokai University)H-Index: 8
#2Kenichi Hirabayashi (Tokai University)H-Index: 14
Last. Naoya Nakamura (Tokai University)H-Index: 24
view all 7 authors...
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