Human Reproduction
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STUDY QUESTION Is there an association between serum LH levels prior to progesterone administration and live birth rate (LBR) in artificial frozen-thawed embryo transfer (FET) cycles? SUMMARY ANSWER : Low serum LH levels on the day before progesterone initiation in artificial frozen-thawed blastocyst transfer cycles of ovulatory women are associated with a lower LBR. WHAT IS KNOWN ALREADY In artificial FET cycles, exogenous oestrogen and progesterone are administered sequentially to mimic the se...
#1Christine DecanterH-Index: 16
Last. Pascal PignyH-Index: 47
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STUDY QUESTION What is the influence of age and chemotherapy regimen on the longitudinal blood anti-Mullerian hormone (AMH) variations in a large series of adolescents and young adult (AYA) (15-24 years old) and non-AYA (25-35 years old) lymphoma patients? SUMMARY ANSWER In case of alkylating regimen treatment, there was a deep and sustained follicular depletion in AYA as well as non-AYA patients; however in both groups, the ovarian toxicity was extremely low in cases of non-alkylating treatment...
#1Iris Yaish (TAU: Tel Aviv University)H-Index: 2
#2Karen Tordjman (TAU: Tel Aviv University)H-Index: 11
Last. Yael Sofer (Tel Aviv Sourasky Medical Center)H-Index: 4
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STUDY QUESTION Is the functional ovarian reserve in transgender men affected by testosterone therapy? SUMMARY ANSWER Serum anti-Mullerian Hormone (AMH) levels slightly decrease during testosterone treatment but remain within the normal range, suggesting preserved follicular ovarian reserve. WHAT IS KNOWN ALREADY Few small studies have investigated the impact of gender-affirming treatment on reproduction in transgender men. Conflicting results were reached concerning ovarian morphology and AMH le...
#1L Grin (BGU: Ben-Gurion University of the Negev)
#2K C T Vo (International University of Health and Welfare)
Last. Kazuhiro Kawamura (International University of Health and Welfare)H-Index: 32
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STUDY QUESTION How is the localisation of ovarian follicles affected by ageing and chronic diseases? SUMMARY ANSWER Ovarian follicles shift deeper towards the medulla, due to thickening of the tunica albuginea (TA), with ageing and some major common chronic diseases. WHAT IS KNOWN ALREADY The ovary undergoes morphological and functional changes with ageing. The follicular pool follows these changes with alterations in the amount and distribution of residual follicles. Diseases causing a chronic ...
STUDY QUESTION Should women with X chromosome abnormalities (XCAs) be recommended to have embryos selected by both morphological and cytogenetic assessment through preimplantation genetic testing (PGT) rather than morphological assessment only in conventional IVF/ICSI treatment? SUMMARY ANSWER PGT is not a preferred recommendation for women with XCAs in the absence of other PGT indications. WHAT IS KNOWN ALREADY XCAs are the most frequent sort of chromosomal aberrations in infertile women. Patie...
#1L. Del Castillo (University of Valencia)H-Index: 5
Last. Antonio PellicerH-Index: 55
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Study question null Does LH protect mouse oocytes and female fertility from alkylating chemotherapy? null Summary answer null LH treatment before and during chemotherapy prevents detrimental effects on follicles and reproductive lifespan. null What is known already null Chemotherapies can damage the ovary, resulting in premature ovarian failure and reduced fertility in cancer survivors. LH was recently suggested to protect prepubertal mouse follicles from chemotoxic effects of cisplatin treatmen...
#1Y Bentov (HUJI: Hebrew University of Jerusalem)
#2Beharier O (HUJI: Hebrew University of Jerusalem)H-Index: 1
Last. Dana G. Wolf (HUJI: Hebrew University of Jerusalem)H-Index: 48
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Study question null Does the immune response to coronavirus disease 2019 (COVID-19) infection or the BNT162b2 mRNA vaccine involve the ovarian follicle, and does it affect its function? null Summary answer null We were able to demonstrate anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG in follicular fluid (FF) from both infected and vaccinated IVF patients, with no evidence for compromised follicular function. null What is known already null No research data are available y...
#1L O Kettner (Aarhus University Hospital)
#2N B Matthiesen (Aarhus University Hospital)
Last. Tine Brink Henriksen (Aarhus University Hospital)H-Index: 82
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#1Tessy Boedt (Katholieke Universiteit Leuven)H-Index: 1
#2Christophe Matthys (Katholieke Universiteit Leuven)H-Index: 31
Last. Carl Spiessens (Katholieke Universiteit Leuven)H-Index: 24
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Study question null Can we develop a preconception lifestyle programme for couples undergoing IVF that is in line with their needs. null Summary answer null A mobile preconception lifestyle programme was systematically developed based on expert opinion, literature and needs of IVF-patients. null What is known already null A healthy lifestyle prior to conception is not only beneficial for the general health of couples, but evidence on its importance for their reproductive health and the health of...
In recent years, the amount of data produced in the field of ART has increased exponentially. The diversity of data is large, ranging from videos to tabular data. At the same time, artificial intelligence (AI) is progressively used in medical practice and may become a promising tool to improve success rates with ART. AI models may compensate for the lack of objectivity in several critical procedures in fertility clinics, especially embryo and sperm assessments. Various models have been developed...
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