Papers 3747
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#1Wansheng Peng (Bengbu Medical College)
#2Lian Wang (Bengbu Medical College)
Last. Xin Chen (Bengbu Medical College)H-Index: 2
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Treg/Th17 cell imbalance and inflammatory response may occur in neonatal asthma. IL-35 and BCG have inhibitory effects on inflammatory responses in diseases. However, studies on neonatal asthma after combination of the two have not been reported so far. A respiratory syncytial virus (RSV)-induced neonatal asthma model was first developed in newborn mice. Pathological sections of lung tissue of asthmatic mice were observed by HE staining. Masson staining was used to observe the lung tissue and to...
#1Yubo Hu (JLU: Jilin University)H-Index: 3
#2Cong Ye (JLU: Jilin University)H-Index: 6
Last. Junyang Chen (JLU: Jilin University)H-Index: 1
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Propofol (PPF) is reported to play a protective role in ischemia/reperfusion (I/R) injury, including cerebral ischemia-reperfusion injury (CIRI). This study aims to investigate the mechanism by which PPF ameliorates CIRI. Kunming mice were used to establish the middle cerebral artery occlusion (MCAO)/reperfusion mouse model in vivo. PPF pre-treatment was performed before CIRI. Lactate dehydrogenase (LDH) and creatine phosphokinase (CPK) levels were detected to evaluate the tissue injury. PC12 ce...
#1Yangye Chen (Hunan Normal University)H-Index: 2
#2Lihua Qu (Hunan Normal University)
Last. Ran Zhang (Hunan Normal University)H-Index: 2
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Acute lung injury (ALI) is mainly caused by severe infection, shock, trauma, and burn, which causes the extensive release of inflammatory factors and other mediators. As a major bioactive constituent of traditional Chinese herb licorice, glycyrrhizic acid (GA) plays an important effect on inflammatory regulation. Nevertheless, the exact mechanism of this effect remains unclear. The present study aims to explore the potential protective effect of GA on LPS-induced ALI. Our results showed that GA ...
#1Junfu Ma (Henan University of Traditional Chinese Medicine)H-Index: 1
#2Qingliang Meng (Henan University of Traditional Chinese Medicine)H-Index: 1
Last. Fuzeng Zheng (Henan University of Traditional Chinese Medicine)H-Index: 1
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Paeoniflorin is an active ingredient derived from Paeonia, which has an anti-inflammatory effect. However, the potential role and basis of paeoniflorin in rheumatoid arthritis (RA) are indistinct. Cell viability, cycle distribution, migration, and invasion were evaluated via Cell Counting Kit-8 (CCK-8), flow cytometry, and transwell assays. The contents of inflammatory cytokines were examined using enzyme-linked immunosorbent assay (ELISA). RNA expression levels were determined via qRT-PCR and w...
#1Narayanappa Amruta (Tulane University)H-Index: 8
#2Gregory J. Bix (Tulane University)H-Index: 8
Ischemic stroke, a disruption of blood flow to a part of the brain most commonly due to a blood clot (thrombus) accounts for ~ 80% of all strokes and is a significant cause of morbidity and mortality. Intravenous recombinant tissue plasminogen activator (tPA) and/or endovascular thrombectomy are currently used to treat acute ischemic stroke [1, 2]. Both treatments result in recanalization/reperfusion, which, although beneficial, can also result in so-called brain ischemia/reperfusion (I/R) injur...
#1Shangrila Parvin (Emory University)H-Index: 1
#2Clintoria R. Williams (Wright State University)H-Index: 5
Last. Sandra M. Garraway (Emory University)H-Index: 12
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Accumulating evidence supports that spinal cord injury (SCI) produces robust inflammatory plasticity. We previously showed that the pro-inflammatory cytokine tumor necrosis factor (TNF)α is increased in the spinal cord after SCI. SCI also induces a systemic inflammatory response that can impact peripheral organ functions. The kidney plays an important role in maintaining cardiovascular health. However, SCI-induced inflammatory response in the kidney and the subsequent effect on renal function ha...
#1Engy R. Rashed (Egyptian Atomic Energy Authority)H-Index: 6
#2Mohamed Khairy Abdel-Rafei (Egyptian Atomic Energy Authority)H-Index: 2
Last. Noura M Thabet (Egyptian Atomic Energy Authority)H-Index: 5
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In radiobiology and radiation oncology fields, the observation of a phenomenon called radiation-induced bystander effect (RIBE) has introduced the prospect of remotely located tissues' affection. This phenomenon has been broadly developed to involve the concept of RIBE, which are relevant to the radiation-induced response of a distant tissue other than the irradiated one. The current study aimed at investigating each of the RIBE of cranial irradiation on oxidative and inflammatory status in diff...
#1Seyed Mohammadreza Bolandi (IAU: Islamic Azad University)
#2Zohreh Abdolmaleki (IAU: Islamic Azad University)H-Index: 5
Last. Mohammad-Ali Assarehzadegan (IUMS: Iran University of Medical Sciences)H-Index: 16
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Studies on the bronchial vascular bed have revealed that the number of blood vessels in the lamina propria and under the mucosa of the lung tissue increases in patients suffering from mild to severe asthma. Thus, in this study, a new strategy was employed in respiratory system disorders by angiogenesis inhibition in an ovalbumin (OVA)-induced rat model of asthma. Twenty-one male Wistar albino rats, 8 weeks old, were randomly divided into three groups (n = 7 in each group), including (1) control ...
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Diabetes mellitus