Tumor Biology
Papers 8958
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#1Mohd Nazmul Hasan Apu (DU: University of Dhaka)H-Index: 4
#2M. N. Aktar (North South University)H-Index: 1
Last. Shaki Mostaid (North South University)H-Index: 1
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OBJECTIVES Genetic susceptibility to cervical cancer in relation to transforming growth factor beta 1 (TGFB1) gene polymorphisms has not been investigated extensively among the women in Bangladesh. So, the aim of this study was to find out the correlation of the polymorphisms of TGFB1 C509T (rs1800469) and T869C (rs1800470) with the risk of cervical cancer among the Bangladeshi women. STUDY DESIGN 134 cervical cancer patients and 102 age-sex matched healthy controls were included from two instit...
#1Beata BiesagaH-Index: 9
Last. Anna Mucha-MałeckaH-Index: 9
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BACKGROUND HPV-16 positivity in patients with squamous cell carcinoma of oropharynx (OPSCC) is associated with better prognosis. However, in more than 40% of HPV infected patients progression of cancer disease is observed, which indicates the presence of cancer cells resistant to therapy. Some studies suggest that there may be a subpopulation of cancer stem cells (CSCs), which simultaneously exhibit unlimited ability to self-renew and differentiate towards neoplastic cells. The relation between ...
#1Maike Busch (University of Duisburg-Essen)H-Index: 6
#2Natalia Miroschnikov (University of Duisburg-Essen)
Last. Nicole Dünker (University of Duisburg-Essen)H-Index: 17
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Background Retinoblastoma (RB) is the most common childhood eye cancer. Chemotherapeutic drugs such as etoposide used in RB treatment often cause massive side effects and acquired drug resistances. Dysregulated genes and miRNAs have a large impact on cancer progression and development of chemotherapy resistances. Objective This study was designed to investigate the involvement of retinoic acid receptor alpha (RARα) in RB progression and chemoresistance as well as the impact of miR-138, a potenti...
#1Kajsa Björkman (UH: University of Helsinki)H-Index: 1
#2Harri Mustonen (UH: University of Helsinki)H-Index: 27
Last. Camilla Böckelman (UH: University of Helsinki)H-Index: 13
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OBJECTIVES The tumor stage represents the single most important prognostic factor for colorectal cancer (CRC), although more accurate prognostics remain much needed. Previously, we identified CA125 as an independent significant prognostic factor, which we have further validated along with CEA, CA19-9, and CA242 in a large cohort of CRC patients. METHODS Using enzyme-linked immunosorbent assays, we analyzed preoperative serum samples in 322 CRC patients operated on between 1998 and 2003. RESULTS ...
#1Yahaya Gavamukulya (Busitema University)H-Index: 5
#2Esther N. Maina (College of Health Sciences, Bahrain)H-Index: 13
Last. Fred Wamunyokoli (JKUAT: Jomo Kenyatta University of Agriculture and Technology)H-Index: 7
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Background Green synthesized nanoparticles have been earmarked for use in nanomedicine including for the development of better anticancer drugs. Objective The aim of this study was to undertake biochemical evaluation of anticancer activities of green synthesized silver nanoparticles (AgNPs) from ethanolic extracts of fruits (AgNPs-F) and leaves (AgNPs-L) of Annona muricata. Methods Previously synthesized silver nanoparticles were used for the study. The effects of the AgNPs and 5-Fluorouracil we...
#1Birgitta Söder (KI: Karolinska Institutet)H-Index: 27
#2Håkan Källmén (KI: Karolinska Institutet)H-Index: 18
Last. Jukka H. Meurman (UH: University of Helsinki)H-Index: 71
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BACKGROUND Oral infections associate statistically with cancer. OBJECTIVE We hypothesized that certain periodontal microorganisms might specifically link to malignancies in general and set out to investigate this in our ongoing cohort study. METHODS A sample of 99 clinically examined patients from our cohort of 1676 subjects was used to statistically investigate the associations between harboring periodontal microorganisms Aggregatibacter actinomycetemcomitans (A.a), Porphyromonas gingivalis (P....
Last. K SujathanH-Index: 4
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Cancer metastasis and therapy resistance are the foremost hurdles in oncology at the moment. This review aims to pinpoint the functional aspects of a unique multifaceted glycosylated molecule in both intracellular and extracellular compartments of a cell namely galectin-3 along with its metastatic potential in different types of cancer. All materials reviewed here were collected through the search engines PubMed, Scopus, and Google scholar. Among the 15 galectins identified, the chimeric gal-3 p...
#1Natalia Ospina-Muñoz (National University of Colombia)H-Index: 1
#2Jean-Paul Vernot (National University of Colombia)H-Index: 7
The interleukin-8 is an important regulator of the tumor microenvironment, promoting the epithelial-mesenchymal transition and the acquisition of stem-like cell properties in cancer cells. The tumorsphere-formation assay has been used for the identification of cancer stem cell. Interleukin-8 induces the formation of larger tumorspheres in Michigan Cancer Foundation-7 (MCF-7) cells, suggesting cancer stem cell enrichment. In this work, we aimed to study the phenotypic and functional characteristi...
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#1Evangelos Koustas (UoA: National and Kapodistrian University of Athens)H-Index: 9
#2Panagiotis Sarantis (UoA: National and Kapodistrian University of Athens)H-Index: 7
Last. Stamatios Theocharis (UoA: National and Kapodistrian University of Athens)H-Index: 51
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Salivary gland carcinomas are a group of heterogeneous tumors of different histological subtypes, presenting relatively low incidence but the entire variable of types. Although novel treatment options for salivary gland carcinomas patients' outcomes have improved, the treatment of this type of cancer is still not standardized. In addition, a significant number of patients, with a lack of optimal treatment strategies, have reduced survival. In the last two decades, a plethora of evidence pointed ...
Top fields of study
Molecular biology
Cancer research