Canadian Journal of Cardiology
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Unstructured abstract Traditional statistical analyses of randomized clinical trials typically employ p-values within a null hypothesis significance testing paradigm. Clinical adoption of randomized trials results, by both guideline writers and individual clinicians, are often unequivocally determined by a deification of p
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#1Shijie Zhou (Johns Hopkins University)H-Index: 5
#2John L. Sapp (Queen Elizabeth II Health Sciences Centre)H-Index: 14
Last. Natalia A. Trayanova (Johns Hopkins University)H-Index: 58
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#1Edward Percy (UBC: University of British Columbia)H-Index: 4
#2Sameer A. Hirji (Brigham and Women's Hospital)H-Index: 11
Last. Marc P Pelletier (Case Western Reserve University)H-Index: 1
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Abstract The role of cardiac surgeons in the treatment of aortic valve disease is changing with the expansion of transcatheter aortic valve replacement (TAVR). Recent trials in patients at low surgical risk will further this paradigm-shift, and the future cardiac surgeons in this space remains uncertain. In this Viewpoint article, we discuss the role that surgeons can play in the future of structural heart medicine. We examine the potential effects of the low-risk TAVR trials on overall operativ...
1 CitationsSource
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#1Chao Gao (Radboud University Nijmegen)H-Index: 2
#2Piotr P. BuszmanH-Index: 15
Last. Aleksander ZurakowskiH-Index: 8
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Abstract Background Radial artery access has been shown to reduce mortality and bleeding events, especially in patients with acute coronary syndromes. Despite this, interventional cardiologists experienced in femoral artery access still prefer this route for percutaneous coronary intervention. Little is known regarding the merits of each vascular access in patients stratified by their risk of bleeding. Methods Patients from the GLOBAL-LEADERS trial were dichotomized into low or high risk of blee...
1 CitationsSource
#1Hiroki Ueyama (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 3
#2Toshiki Kuno (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 9
Last. Hisato TakagiH-Index: 25
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Abstract Background Although different transcatheter heart valve (THV) systems have been introduced to overcome transcatheter aortic valve replacement (TAVR) specific complications, head-to-head comparisons of these THV systems are scarce. The aim of this study was to compare different THV systems and surgical aortic valve replacement (SAVR) by conducting a network meta-analysis. Methods PUBMED and EMBASE were searched through November 2019 for studies comparing safety and efficacy of balloon-ex...
3 CitationsSource
#1Justin N. Chee (U of T: University of Toronto)H-Index: 4
#2Christopher S. Simpson (Queen's University)H-Index: 31
Last. Mark J. Rapoport (U of T: University of Toronto)H-Index: 29
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ABSTRACT BACKGROUND Drivers at risk of sudden incapacitation from syncope pose a potential threat to themselves and to society. The purpose of this systematic review is to synthesize the risk of motor vehicle collisions (MVC) for patients with a history of syncope. METHODS We systematically searched MEDLINE (1946 – 2019) as well as CINAHL, Embase, Psychinfo and the Transportation Research Information Documentation (1806 – 2017) for articles on MVC and drivers with vasovagal syncope (VVS), arrhyt...
1 CitationsSource
#1Malak Almutairi (U of A: University of Alberta)H-Index: 4
#2Keshav Gopal (U of A: University of Alberta)H-Index: 14
Last. John R. Ussher (U of A: University of Alberta)H-Index: 28
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Abstract Background Type 2 diabetes (T2D) increases risk for cardiovascular disease. Of interest, liraglutide, a therapy for T2D that activates the glucagon-like peptide-1 receptor (GLP-1R) to augment insulin secretion, reduces cardiovascular-related death in people with T2D, though it remains unknown how liraglutide produces these actions. Notably, the GLP-1R is not expressed in ventricular cardiac myocytes, making it likely that ventricular myocardium-independent actions are involved. We hypot...
3 CitationsSource
#1Xinying Yang (Capital Medical University)H-Index: 2
#2Xiaoyu Du (JLU: Jilin University)H-Index: 3
Last. Jie Du (Capital Medical University)H-Index: 54
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Abstract Background Long-term morbidity and mortality of patients with ST-segment elevation myocardial infarction (STEMI) after primary percutaneous coronary intervention (PCI) remain substantial. Circulating microRNAs (miRNAs) play an important role in cardiovascular disease development. We aimed to identify circulating miRNAs associated with adverse cardiovascular events post-acute myocardial infarction (AMI). Methods We performed a prospective, nested, case–control study of 932 patients with ...
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#1Alexander C. Egbe (Mayo Clinic)H-Index: 17
#2Rahul Vojjini (Mayo Clinic)H-Index: 1
Last. Barry A. Borlaug (Mayo Clinic)H-Index: 64
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Abstract Background Pulmonary artery wedge pressure (PAWP) is often elevated in patients with right-sided congenital heart disease (CHD), raising the possibility of coexisting left heart disease, but pressure-volume relationships in the left and right sides of the heart influence one another through interdependence, which may be amplified in patients with CHD. Methods We hypothesized that increases in PAWP in CHD patients would be more strongly related to ventricular interdependence as compared ...
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