Matrix Biology
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#1Alexandra C Finney (LSU: Louisiana State University)
#2Matthew L. Scott (LSU: Louisiana State University)H-Index: 1
Last. J. Steven Alexander (LSU: Louisiana State University)H-Index: 44
view all 13 authors...
Abstract null null The multifunctional glycoprotein fibronectin influences several crucial cellular processes and contributes to multiple pathologies. While a link exists between fibronectin-associated pathologies and the receptor tyrosine kinase EphA2, the mechanism by which EphA2 promotes fibronectin matrix remodeling remains unknown. We previously demonstrated that EphA2 deletion reduces smooth muscle fibronectin deposition and blunts fibronectin deposition in atherosclerosis without influenc...
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#1Christian Hundhausen (HHU: University of Düsseldorf)
#2Rebekka Schneckmann (HHU: University of Düsseldorf)H-Index: 1
Last. Olaf Eckermann (HHU: University of Düsseldorf)H-Index: 4
view all 16 authors...
The association between hyaluronan (HA) accumulation and increased inflammation in the colon suggests that HA is a potential therapeutic target in inflammatory bowel disease (IBD). However, whether patients with IBD would benefit from interference with HA synthesis is unknown. Here, we used pharmacological and genetic approaches to investigate the impact of systemic and partial blockade of HA synthesis in the Dextran Sodium Sulfate (DSS)-induced colitis model. To systemically inhibit HA producti...
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#1Florian Peters (UZH: University of Zurich)H-Index: 6
#2Sascha Rahn (CAU: University of Kiel)H-Index: 5
Last. Ronald NaumannH-Index: 32
view all 12 authors...
Abstract null null Dysregulation of proteolytic enzymes has huge impact on epidermal homeostasis, which can result in severe pathological conditions such as fibrosis or Netherton syndrome. The metalloprotease meprin β was found to be upregulated in hyperproliferative skin diseases. AP-1 transcription factor complex has been reported to induce Mep1b expression. Since AP-1 and its subunit fos-related antigen 2 (fra-2) are associated with the onset and progression of psoriasis, we wanted to investi...
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#1Prashant Chandrasekaran (Drexel University)H-Index: 6
#2Bryan Kwok (Drexel University)H-Index: 2
Last. David B. Frank (Children's Hospital of Philadelphia)H-Index: 14
view all 13 authors...
This study queried the role of type V collagen in the post-natal growth of temporomandibular joint (TMJ) condylar cartilage, a hybrid tissue with a fibrocartilage layer covering a secondary hyaline cartilage layer. Integrating outcomes from histology, immunofluorescence imaging, electron microscopy and atomic force microscopy-based nanomechanical tests, we elucidated the impact of type V collagen reduction on TMJ condylar cartilage growth in the type V collagen haploinsufficiency and inducible k...
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#1Bo Sun (Harvard University)H-Index: 11
#2Beverly Tomita (Harvard University)H-Index: 2
Last. Dieter P. Reinhardt (McGill University)H-Index: 52
view all 12 authors...
The formation of elastic fibers is active only in the perinatal period. How elastogenesis is developmentally regulated is not fully understood. Citrullination is a unique form of post-translational modification catalyzed by peptidylarginine deiminases (PADs), including PAD1-4. Its physiological role is largely unknown. By using an unbiased proteomic approach of lung tissues, we discovered that FBLN5 and LTBP4, two key elastogenic proteins, were temporally modified in mouse and human lungs. We fu...
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#1Liliana Schaefer (Goethe University Frankfurt)H-Index: 67
#2Ivan Dikic (Goethe University Frankfurt)H-Index: 116
In recent years, extensive research has uncovered crucial regulatory roles for the extracellular matrix (ECM) in regulating autophagy. Autophagy is a ubiquitous and highly conserved catabolic process that allows the selective removal and recycling of cytosolic components via lysosomal or vacuolar degradation. Due to its pivotal role in cellular homeostasis, the impairment of autophagy is involved in the pathophysiology of numerous diseases, comprising infectious diseases, immune and neurodegener...
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#1Vedavathi Madhu (Thomas Jefferson University)H-Index: 3
#2Anyonya R Guntur (Tufts University)H-Index: 1
Last. Makarand V. Risbud (Thomas Jefferson University)H-Index: 64
view all 3 authors...
The intervertebral disc and cartilage are specialized, extracellular matrix-rich tissues critical for absorbing mechanical loads, providing flexibility to the joints, and longitudinal growth in the case of growth plate cartilage. Specialized niche conditions in these tissues, such as hypoxia, are critical in regulating cellular activities including autophagy, a lysosomal degradation pathway that promotes cell survival. Mounting evidence suggests that dysregulation of autophagic pathways undersco...
5 CitationsSource
#1Silvia Castagnaro (UNIPD: University of Padua)H-Index: 7
#2Lisa Gambarotto (UNIPD: University of Padua)H-Index: 1
Last. Paolo Bonaldo (UNIPD: University of Padua)H-Index: 64
view all 4 authors...
Autophagy is a very versatile process through which the cell degrades damaged long-lived proteins, entire organelles, or pathogens, by engulfing them in characteristic double-membrane vesicles and conveying the cargo to lysosomes. It is a dynamic pathway tunable at multiple levels and responsive to nutrient and stress stimuli, also coming from the extracellular microenvironment and its remodeling. In the extracellular matrix, collagen type VI forms a distinctive set of beaded microfilaments that...
2 CitationsSource
#1Laura Zein (Goethe University Frankfurt)H-Index: 1
#2Simone Fulda (Goethe University Frankfurt)H-Index: 98
Last. Sjoerd J. L. van Wijk (Goethe University Frankfurt)H-Index: 13
view all 4 authors...
The conserved catabolic process of autophagy is an important control mechanism that degrades cellular organelles, debris and pathogens in autolysosomes. Although autophagy primarily protects against cellular insults, nutrient starvation or oxidative stress, hyper-activation of autophagy is also believed to cause autophagy-dependent cell death (ADCD). ADCD is a caspase-independent form of programmed cell death (PCD), characterized by an over-activation of autophagy, leading to prominent self-dige...
1 CitationsSource
#1Linlin Lei (RUB: Ruhr University Bochum)H-Index: 1
#2Zhixiao Wu (RUB: Ruhr University Bochum)H-Index: 1
Last. Konstanze F. Winklhofer (RUB: Ruhr University Bochum)H-Index: 49
view all 3 authors...
Degradation of dysfunctional, damaged, or misfolded proteins is a crucial component of the protein quality control network to maintain cellular proteostasis. Dysfunction in proteostasis regulation due to imbalances in protein synthesis, folding, and degradation challenges the integrity of the cellular proteome and favors the accumulation of aggregated proteins that can damage cells by a loss of their functions and/or a gain of adverse functions. Ubiquitination is an essential player in proteosta...
4 CitationsSource
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