Journal of Orthopaedic Research
Papers 7059
1 page of 706 pages (7,059 results)
#1Agnieszka J Turlo (University of Liverpool)
#2B.T. McDermott (University of Liverpool)H-Index: 6
Last. Peter D. Clegg (University of Liverpool)H-Index: 48
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Osteoarthritis (OA) is a disease of the entire joint but the relationship between pathological events in various joint tissues is poorly understood. We examined concurrent changes in bone, cartilage, and synovium in a naturally occurring equine model of joint degeneration. Joints (n = 64) were grossly assessed for palmar/plantar osteochondral disease (POD) in racehorses that required euthanasia for unrelated reasons and assigned a grade of 0 (n = 34), 1 (n = 17), 2 or 3 (n = 13) using a recogniz...
#1Hideyuki Kobayashi (Hokkaido University)H-Index: 2
#2Ryo Fujita (Hokkaido University)H-Index: 4
Last. Masahiko Takahata (Hokkaido University)H-Index: 28
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Osteomyelitis is characterized by progressive inflammatory bone destruction accompanied by severe pain and disability. However, with the exception of antibiotic therapies, there is no established therapy to protect the bone from infectious osteolysis. The anti-receptor activator of nuclear factor-kB ligand (RANKL) monoclonal antibody (anti-RANKL Ab) is a potential drug based on its proven effectiveness in preventing joint bone erosion in rheumatoid arthritis; however, the efficacy and adverse ef...
#1Wenzhao Wang (Sichuan University)H-Index: 2
#2Liang Ma (SDUTCM: Shandong University of Traditional Chinese Medicine)
Last. Wei Xie (Sichuan University)H-Index: 2
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Long non-coding RNAs (lncRNAs) have been demonstrated to play critical regulatory roles in posttranscriptional and transcriptional regulation in eukaryotic cells. However, the characteristics of many lncRNAs, particularly their expression patterns in the lesion epicenter of spinal tissues following sub-acute spinal cord injury (SCI), remain unclear. In this study, we determined the expression profiles of lncRNAs in the lesion epicenter of spinal tissues after traumatic SCI and predicted latent r...
#1Ian Peeters (UGent: Ghent University)H-Index: 3
#2Nele Pien (UGent: Ghent University)H-Index: 3
Last. Ann Martens (UGent: Ghent University)H-Index: 20
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A reinforced tubular, medicated electrospun construct was developed for deep flexor tendon repair. This construct combines mechanical strength with the release of anti-inflammatory and anti-adhesion drugs. In this study, the reinforced construct was evaluated using a rabbit model. It was compared to its components (a tubular, medicated electrospun polymer without reinforcement and a tubular braid as such) on the one hand to a modified Kessler suture as a control group. Forty New Zealand rabbits ...
#1Annina E. A. Saukko (University of Eastern Finland)H-Index: 3
#2Jaakko K. Sarin (University of Eastern Finland)H-Index: 6
Last. Juha TöyräsH-Index: 44
view all 13 authors...
To prevent the progression of posttraumatic osteoarthritis, assessment of cartilage composition is critical for effective treatment planning. Posttraumatic changes include proteoglycan (PG) loss and elevated water content. Quantitative dual-energy computed tomography (QDECT) provides a means to diagnose these changes. Here, we determine the potential of QDECT to evaluate tissue quality surrounding cartilage lesions in an equine model, hypothesizing that QDECT allows detection of posttraumatic de...
#1Timothy W. Tourville (UVM: University of Vermont)H-Index: 18
#2Thomas B. Voigt (UVM: University of Vermont)H-Index: 3
Last. Michael J. Toth (UVM: University of Vermont)H-Index: 44
view all 8 authors...
Muscle dysfunction following anterior cruciate ligament reconstruction (ACLR) may evolve from alterations in muscle contractility at the myofilament protein level. Using a prospective, within-subject case control design, we evaluated cellular-level contractility, cross-sectional area (CSA), and myosin heavy chain (MHC) isoform expression on single muscle fibers 3-weeks post ACLR, and evaluated their relationship to whole muscle strength and patient-oriented outcomes 6 months post-op. Biopsies of...
#1Pendar Soltanmohammadi (UWO: University of Western Ontario)
#2Amir Tavakoli (UWO: University of Western Ontario)
Last. Ryan Willing (UWO: University of Western Ontario)H-Index: 13
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Stress shielding of the proximal humerus following total shoulder arthroplasty (TSA) can promote unfavorable bone remodeling, especially for osteoporotic patients. The objective of this finite element (FE) study was to determine if a hollow, rather than solid, titanium stem can mitigate this effect for healthy, osteopenic, and osteoporotic bone. Using a population-based model of the humerus, representative average healthy, osteopenic, and osteoporotic humerus FE models were created. For each mod...
#1Caroline Struijk (Mayo Clinic)
#2Wouter Van Genechten (Mayo Clinic)H-Index: 2
Last. Daniel B.F. Saris (Mayo Clinic)H-Index: 43
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Meniscus allograft transplantations (MAT) represent established surgical procedures with proven outcomes. Yet, storage as frozen specimens and limited cellular repopulation may impair graft viability. This proof of concept study tests the feasibility of injecting allogeneic mesenchymal stromal/stem cells (MSCs) in meniscus allograft tissue. We investigated the injectable cell quantity, survival rate, migration and proliferation ability of MSCs up to 28 days of incubation. In this controlled labo...
#1Linda K Truong (UBC: University of British Columbia)H-Index: 2
#2Amber D. Mosewich (U of A: University of Alberta)H-Index: 11
Last. Jackie L. Whittaker (UBC: University of British Columbia)H-Index: 20
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Attitudes, priorities, and perceptions of exercise directly influence exercise behaviors. Despite the benefits of exercise-based activities for future health, little is known about how youth who experience an ACL injury view exercise-based activity beyond the immediate recovery period. A qualitative (interpretative description) approach with one-to-one semi-structured interviews was used to probe the current attitudes, priorities, and perceptions of exercise-therapy, physical activity, and sport...
#1Honey Hendesi (UPenn: University of Pennsylvania)
#2Suzanne Stewart (UPenn: University of Pennsylvania)H-Index: 6
Last. George R. Dodge (UPenn: University of Pennsylvania)H-Index: 30
view all 6 authors...
Post-traumatic osteoarthritis is a disabling condition impacting the mostly young and active population. In the present study, we investigated the impact of intra-articular sprifermin, a recombinant truncated fibroblast growth factor 18, on the outcome of microfracture treatment, a widely used surgical technique to enhance cartilage healing at the site of injury. For this study, we created a cartilage defect and performed microfracture treatment in fetlock joints of 18 horses, treated joints wit...
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