Aaps Pharmscitech
Papers 3634
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#1Manal A. Elsheikh (Damanhour University)H-Index: 6
#2Samar A Rizk (Alexandria University)
Last. Ossama Y. Abdallah (Alexandria University)H-Index: 26
view all 4 authors...
Andrographolide (AG) is an antitumor phytochemical that acts against non-Hodgkin's lymphoma. However, AG shows low oral bioavailability due to extensive first-pass metabolism and P-glycoprotein efflux. Novel biocompatible lipoprotein-simulating nanosystems, emulsomes (EMLs), have gained significant attention due to their composition of natural components, in addition to being lymphotropic. Loading AG on EMLs is believed to mitigate the disadvantage of AG and enhance its lymphatic transport. This...
#1Xinggang Yang (SPU: Shenyang Pharmaceutical University)H-Index: 24
#2Pan Gao (SPU: Shenyang Pharmaceutical University)
Last. Mengsuo Cui (SPU: Shenyang Pharmaceutical University)H-Index: 7
view all 6 authors...
The aim of this article was to design a self-emulsifying drug delivery system (SEDDS) of loaded cepharanthine (CEP) to improve the oral bioavailability in rats. Based on the solubility determination and pseudo-ternary phase diagram, isopropyl palmitate (IPP) was chosen as the oil phase. Meanwhile, Cremophor RH40 and Macrogol 200 (PEG 200) were chosen as the emulsifier and co-emulsifier, respectively. This prescription was further optimized by using central composite design of response surface me...
#1Rahil Dalal (NU: Nirma University of Science and Technology)
#2Jigar Shah (NU: Nirma University of Science and Technology)H-Index: 11
Last. Anroop B. Nair (King Faisal University)H-Index: 28
view all 8 authors...
Asenapine, an atypical antipsychotic agent, has been approved for the acute and maintenance treatment of schizophrenia and manic episodes of bipolar disorder. However, the extensive hepatic metabolism limits its oral bioavailability. Therefore, the objective of the current investigation was to develop sublingual film containing asenapine to enhance the therapeutic efficacy. Sublingual films containing asenapine were fabricated using polyethylene oxide and hydroxypropyl methylcellulose by solvent...
#1Gayathri Ramachandran (Amrita Vishwa Vidyapeetham)
#2M. S. Sudheesh (Amrita Vishwa Vidyapeetham)
An ideal dissolution test for amorphous solid dispersions (ASDs) should reflect physicochemical, physiological, and hydrodynamic conditions which accurately represent in vivo dissolution. However, this is confounded by the evolution of different molecular and colloidal species during dissolution, generating a supersaturated state of the drug. The supersaturated state of a drug is thermodynamically unstable which drives the process of precipitation resulting in a loss of solubility advantage. Mai...
#1Mumuni Sumaila (University of the Witwatersrand)H-Index: 1
#2Thashree Marimuthu (University of the Witwatersrand)H-Index: 13
Last. Yahya E. Choonara (University of the Witwatersrand)H-Index: 38
view all 4 authors...
Nanosystems that incorporate both polymers and lipids have garnered attention as emerging nanotechnology approach for oral drug delivery. These hybrid systems leverage on the combined properties of polymeric and lipid-based nanocarriers while eliminating their inherent limitations. In view of the safety-related benefits of naturally occurring polymers, we have focused on systems incorporating polysaccharides and derivatives into the hybrid structure. The aim of this review is to evaluate existin...
The purpose of this study was to enhance the antitumor effect of piperine by constructing the nanoparticles modified with transferrin (Tf-PIP-NPs) and evaluating their efficacy in vitro and in vivo. The Tf-PIP-NPs were prepared by the solvent evaporation method, and their properties were characterized. The effects of Tf-PIP-NPs on cytotoxicity, cell uptake, apoptosis, and mitochondrial membrane potential were evaluated in HepG2 cells, MDA-MB-231 cells, and 4T1 cells. In a 4T1 tumor-bearing mouse...
#1Manee Luangtana-anan (SU.: Silpakorn University)H-Index: 19
#2Suthep Saengsod (SU.: Silpakorn University)H-Index: 2
Last. Sontaya Limmatvapirat (SU.: Silpakorn University)H-Index: 22
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The objective of this study was to stabilize the enteric property of bleached shellac by composite formation with ethyl cellulose. The composite film at the ratio of 9:1, 8:2, 7:3, 6:4, and 5:5 was prepared by the film casting method. The physicochemical properties were acid value, insoluble solid, water permeability coefficient, % polarity, mechanical property, FTIR, PXRD, DSC, % solubility in aqueous, and various pH (1.2 and 7.4). All the films were able to protect against the low pH and water...
#1Kai-Wei Wu (University of Mississippi)H-Index: 3
#2Corinne Sweeney (University of Mississippi)H-Index: 3
Last. Soumyajit Majumdar (University of Mississippi)H-Index: 31
view all 7 authors...
Primaquine (PQ), an 8-aminoquinoline antimalarial drug, has been widely used for the eradication of hypnozoites from the liver and, therefore, recognized as the radical cure of malaria. However, the clinical applications of PQ are restricted to patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency due to severe dose-related hemolytic side effects. Nanoparticle carriers have shown great potential in achieving higher PQ concentrations in the target site, thereby reducing dose-related s...
#1Sudeep Sudesh Pukale (BITS: Birla Institute of Technology and Science)H-Index: 3
#2Anupama Mittal (BITS: Birla Institute of Technology and Science)H-Index: 13
Last. Deepak Chitkara (BITS: Birla Institute of Technology and Science)H-Index: 15
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Lipid-polymer hybrid nanoparticles display several benefits over either lipid and/or polymer based systems with respect to enhanced drug loading, good colloidal stability, sustained release profile, and high cellular uptake. The present work rivets on development and evaluation of vitamin D3-loaded monolithic lipid-polymer hybrid nanoparticles (VD3/LPHNPs) for their in vivo anti-psoriatic efficacy. These LPHNPs were prepared using a hot homogenization method and exhibited spherical morphology wi...
#1Fangqin Fu (JNU: Jinan University)H-Index: 1
#2Xin Li (Southern Medical University)
Last. Chuanbin Wu (JNU: Jinan University)H-Index: 3
view all 9 authors...
Sealing the therapeutic agents in the root canal is considered to be an essential step in root canal therapy. The lyotropic liquid crystalline precursor (LLCP) incorporated with chlorhexidine (CHX) and silver nanoparticles (Ag-NPs) has been confirmed as a promising candidate for root canal therapy in the previous study. Importantly, the stability of the LLCP system was a significant determinant for its therapeutic effect and further application. The objective of this study was to comprehensively...
Top fields of study
Drug carrier
Organic chemistry
Particle size
Materials science
Drug delivery