Expert Review of Respiratory Medicine
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INTRODUCTION SARS-COV2 infection represents a therapeutic challenge due to the limited number of effective therapies available and due to the fact that it is not clear which host response in terms of inflammation pattern is the most predictive for an optimal (and rapid) recovery. Interferon β pathway is impaired in SARS-COV2 infection and this is associated with a bigger disease burden. Exogenous inhaled interferon might be beneficial in this setting. AREAS COVERED Nebulized interferon-β is curr...
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Introduction null Fixed-dose long-acting beta2-agonist (LABA)/inhaled corticosteroid (ICS) combinations and add-on therapies as needed are the mainstay for maintenance therapy in asthma. However, more than 40% of patients have an inadequately controlled disease. The development of triple fixed-dose combinations consisting of long-acting muscarinic antagonist (LAMA)/LABA/ICS has paved the way for a new approach to reach therapeutic goals of an optimal control of symptoms and an effective preventi...
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Introduction null Dyspnea occurring in chronic obstructive pulmonary disease (COPD) that is refractory to traditional management strategies is a common and challenging problem. Considerable attention has been paid to the off-label use of orally administered opioids as a pharmacotherapy option for refractory dyspnea in COPD. Multiple professional respiratory society guidelines express support for the application of oral opioids for this purpose. null Areas covered null This manuscript will critic...
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#1Kevin K. BrownH-Index: 113
#2S. Rajan (Bombay Hospital, Indore)H-Index: 6
Last. Jaideep GogtayH-Index: 10
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Introduction null Mycophenolate mofetil (MMF), initially approved to prevent rejection in solid organ allograft, is now being increasingly used for other conditions. Over the last decade, MMF has emerged as a useful therapy for a variety of immune-mediated diseases. null Areas covered null There has been a growing interest in the clinical use of MMF in the treatment of ILDs due to its versatile anti-inflammatory, immunomodulatory, anti-fibrotic and anti-proliferative properties. In this focussed...
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#1Sanket Meghpara (Tripler Army Medical Center)
#2Moeed Chohan (SUNY Upstate Medical University)
Last. Macario Camacho (Tripler Army Medical Center)H-Index: 25
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INTRODUCTION Myofunctional therapy (MT) improves obstructive sleep apnea (OSA) in patients. AREAS COVERED We systematically reviewed publications to evaluate MT as a treatment for OSA. We identified relevant articles and performed a meta-analysis on apnea-hypopnea index (AHI) scores, lowest oxygen saturation (LSAT), and Epworth Sleepiness Scale (ESS). Search databases were retained as primary data sources with the search performed through 18 June 2021. EXPERT OPINION Fifteen studies with 237 pat...
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#1Qi Liu (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Hai Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 7
Last. Feng Li (SJTU: Shanghai Jiao Tong University)H-Index: 119
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INTRODUCTION Interstitial lung abnormalities (ILAs), which refer to mild or subtle nongravity-dependent interstitial changes, may be neglected by some clinicians due to many reasons, such as lack of diagnostic criteria for ILAs and absence of available treatments and surveillance strategies. However, without intervention, some ILAs may progress to interstitial lung disease (ILD). This review summarizes our current knowledge of this condition and ways of diagnosing it together with current manage...
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#1Behnam Rabiee (AECOM: Albert Einstein College of Medicine)
#2Liesl S. Eibschutz (USC: University of Southern California)
Last. Ali Gholamrezanezhad (USC: University of Southern California)H-Index: 21
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Introduction null Limited data exist regarding the long-term pulmonary sequelae of COVID-19. Identifying features utilizing multiple imaging modalities engenders a clearer picture of the illness's long-term consequences. null Areas covered null This review encompasses the common pulmonary findings associated with different imaging modalities during acute and late remission stages of COVID-19 pneumonia. null Expert opinion null Chest x-ray, a common preliminary diagnostic imaging technique, is no...
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Background null Pulmonary rehabilitation (PR) (primarily composed of an exercise training program (ET) and educational workshops) is an effective intervention for patients with chronic obstructive pulmonary disease. Although factors which influence participation in the full PR program have been reported, specific data on the educational component of PR have not been published. We aimed to identify factors which predict refusal to participate in the educational component of PR. null Research desi...
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#1Michael Williamson (RCSI: Royal College of Surgeons in Ireland)
#2Michelle Casey (RCSI: Royal College of Surgeons in Ireland)
Last. Emer P. Reeves (RCSI: Royal College of Surgeons in Ireland)H-Index: 37
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Introduction null Cystic fibrosis (CF) is a genetically inherited disease, with mortality and morbidity associated with respiratory disease. The inflammatory response in CF is characterized by excessive neutrophil influx to the airways, mainly due to the increased local production and retention of interleukin-8 (IL-8), a potent neutrophil chemoattractant. null Areas covered null : We discuss how the chemokine IL-8 more than any other dominates the inflammatory profile of the airways in CF lung d...
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#1Juan F. MasaH-Index: 35
#2Maxime Patout (University of Paris)H-Index: 1
Last. João Carlos Winck (University of Porto)H-Index: 20
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Introduction null : Respiratory high dependency units (RHDU) set up in European countries in the last decade are based on being a transitional step between the intensive care units (ICU) and the conventional hospital ward in terms of staffing, level of monitoring and patients' severity. In the pre-COVID-19 era, its main use has been the treatment of hypercapnic acute-on-chronic respiratory failure with noninvasive respiratory support and more recently for hypoxemic acute respiratory failure. nul...
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