Molecular and Cellular Biochemistry
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3.40
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#1Aishwarya Singh (AIIMS: All India Institute of Medical Sciences)
#2Nidhi Rani Gupta (AIIMS: All India Institute of Medical Sciences)H-Index: 23
Last. Alpana Sharma (AIIMS: All India Institute of Medical Sciences)H-Index: 23
view all 7 authors...
Urothelial carcinoma of bladder (UBC), a highly prevalent urological malignancy associated with high mortality and recurrence rate. Standard diagnostic method currently being used is cystoscopy but its invasive nature and low sensitivity stresses for identifying predictive diagnostic marker. Autophagy, a cellular homeostasis maintaining process, is usually dysregulated in cancer and its role is still enigmatic in UBC. In this study, 30 UBC patients and healthy controls were enrolled. Histopathol...
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#1Abhilasha Singh (DU: University of Delhi)
#2Sudhir Verma (DU: University of Delhi)H-Index: 1
Last. Jogeswar Satchidananda Purohit (DU: University of Delhi)H-Index: 6
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Histones are classically known to organize the eukaryotic DNA into chromatin. They are one of the key players in regulating transcriptionally permissive and non-permissive states of the chromatin. Nevertheless, their context-dependent appearance within the cytoplasm and systemic circulation has also been observed. The past decade has also witnessed few scientific communications on the existence of vesicle-associated histones. Diverse groups have attempted to determine the significance of these e...
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#1Xian-Liang TangH-Index: 13
#2Marcin WysoczynskiH-Index: 39
Last. Roberto BolliH-Index: 126
view all 8 authors...
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#1Pei He (Soochow University (Suzhou))H-Index: 9
#2Fei Jiang (Soochow University (Suzhou))H-Index: 2
Last. Fei-Yan Deng (Soochow University (Suzhou))H-Index: 22
view all 6 authors...
SNP rs3755955 (major/minor allele: G/A) located in Iduronidase-Alpha-L- (IDUA) gene was reported to be significant for human bone mineral density (BMD). This follow-up study was to uncover the underlying association mechanism through molecular and cellular functional assays relevant to bone. We tested the effects of single nucleotide polymorphisms (SNP) rs3755955 (defined allele G as wild-type and allele A as variant-type) on osteoblastic and osteoclastic functions, as well as protein phosphoryl...
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#1Georgia Margioula-Siarkou (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 1
#2Chrysoula Margioula-Siarkou (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 10
Last. Georgios Mavromatidis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 10
view all 10 authors...
Preeclampsia remains till today a leading cause of maternal and fetal morbidity and mortality. Pathophysiology of the disease is not yet fully elucidated, though it is evident that it revolves around placenta. Cellular ischemia in the preeclamptic placenta creates an imbalance between angiogenic and anti-angiogenic factors in maternal circulation. Endoglin, a transmembrane co-receptor of transforming growth factor β (TGF-β) demonstrating angiogenic effects, is involved in a variety of angiogenes...
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#1Subah Soni (Monmouth University)
#2Mruga Y. Parekh (Monmouth University)
Last. Dorothy E. Lobo (Monmouth University)
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Kumquats are small citrus fruits produced by the Fortunella japonica tree. In addition to its aroma, kumquat essential oil may have antiproliferative effects; however, research on the effects of kumquat essential oil on human cell lines is limited. This study investigated the effects of kumquat essential oil on the proliferation of three human cell lines (HT-1080 fibrosarcoma cells, HeLa cervical adenocarcinoma cells, and CUA-4 normal human fibroblasts). As the concentration of kumquat essential...
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#1Mo Li (Dalian Medical University)
#2Xin Du (Dalian Medical University)
Last. Yu Bai (Dalian Medical University)
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Inflammatory responses change several aspects of malignancies such as proliferation, survival, angiogenesis, and metastasis and lead to tumor progression. Lung cancer is the leading type of cancer worldwide and cancer-related inflammatory mediators challenge the successful treatments. Lentinan, a polysaccharide derived from Lentinula edodes, has shown anti-inflammatory characteristics in colitis and has been approved as an adjuvant therapy for cancer treatment. In the present study, we explored ...
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#1Jie Ju (Qingdao University)H-Index: 1
#2Ya-nan Song (Qingdao University)H-Index: 1
Last. Kun Wang (Qingdao University)H-Index: 63
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Circular RNAs (circRNAs), a novel class of endogenous noncoding RNA, are characterized by their covalently closed-loop structures without a 5' cap or a 3' poly(A) tail. With the evolution of high-throughput sequencing technology and bioinformatics, an increasing number of circRNAs have been discovered, and their functions were highlighted. Cardiovascular diseases (CVDs) have become the world's leading killers, with serious impacts on human health. Although significant progress has been made in c...
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#1N Prajitha (Sree Chitra Thirunal Institute for Medical Sciences and Technology)
#2P V Mohanan (Sree Chitra Thirunal Institute for Medical Sciences and Technology)
Phytohemagglutinin (PHA) is a plant mitogen that can agglutinate human leukocytes and erythrocytes. PHA is mainly derived from red kidney beans and can act as an exogenous pyrogen. When entering into the blood circulation, exogenous pyrogens principally interact with monocytes and macrophages and induce the release of pro-inflammatory cytokines. Monocytes and macrophages are the cells that fight against foreign invaders and acts as a primary line of immune defence. Similar to PHA, the chemical 2...
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#1Jing Wang (Fujian Medical University)
#2Mei Gong (Fujian Medical University)
Last. Cheng Huang (Fujian Medical University)
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Lung cancer is one of the most prevalent causes of morbidity and mortality in both men and women across the globe. The disease has a quiet phenotype at first, which leads to chronic tumor development. Non-small cell lung cancer (NSCLC) is the most common kind of lung cancer, accounting for 85 percent of all lung malignancies. Autophagy has been described as an intracellular "recycle bin" where damaged proteins and molecules are degraded. Autophagy regulation is mainly dependent on signaling path...
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