Current Rheumatology Reports
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#1Theonymfi Doudouliaki (GOSH: Great Ormond Street Hospital)
#2Charalampia Papadopoulou (ICH: UCL Institute of Child Health)H-Index: 5
Last. Claire T Deakin (ICH: UCL Institute of Child Health)H-Index: 12
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PURPOSE OF REVIEW This review aims to present the literature available to date on the use of intravenous immunoglobulin and cyclophosphamide for juvenile patients with inflammatory myopathies, to evaluate the strength of the evidence so far for both these medications, and to reach conclusions about their efficacy. RECENT FINDINGS Juvenile idiopathic inflammatory myopathies, mainly represented by juvenile dermatomyositis (JDM), are rare diseases but quite debilitating for the patients. JDM is an ...
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#1Gabriella Giancane (UniGe: University of Genoa)H-Index: 10
#2Silvia Rosina (Istituto Giannina Gaslini)H-Index: 6
Last. Nicolino Ruperto (Istituto Giannina Gaslini)H-Index: 67
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PURPOSE OF REVIEW Providing a summary of the latest research on outcome measures in juvenile idiopathic arthritis, childhood -onset systemic lupus erythematosus, and juvenile dermatomyositis. RECENT FINDINGS A rational management of patients with pediatric rheumatic diseases requires the regular assessment of the level of disease activity and damage, as well as the evaluation of therapeutic response through validated and standardized outcome measures. Ideally, such tools should be simple, feasib...
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#1Stinne Ravn Greisen (AU: Aarhus University)H-Index: 9
#2Bent Deleuran (AU: Aarhus University)H-Index: 34
PURPOSE OF REVIEW This review will focus on the most common co-inhibitory molecules, emphasizing the importance of these in relation to rheumatic disease. RECENT FINDINGS Checkpoint molecules are pivotal in determining the outcome of antigen activation. Checkpoint molecules consist of co-stimulatory and co-inhibitory molecules, where the first activates and the latter inhibits the antigen presentation process. Studies show that increased activity of co-inhibitory molecules is associated with a g...
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#1Vanessa L. Kronzer (Mayo Clinic)H-Index: 5
#2John M. Davis (Mayo Clinic)H-Index: 27
PURPOSE OF REVIEW Over the last few years, the scientific community has made significant progress in understanding the etiology of rheumatoid arthritis (RA). In this review, we summarize those key findings and trends. RECENT FINDINGS New data strongly implicates respiratory exposures, obesity, diet and microbiome, genetics, and their interactions in the etiology of RA. Furthermore, anti-posttranslationally modified protein antibodies (AMPAs) and abnormal glycosylation may be additional biomarker...
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#1Enrico TombettiH-Index: 12
#2E. Hysa (UniGe: University of Genoa)H-Index: 1
Last. Dario Camellino (UniGe: University of Genoa)H-Index: 12
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PURPOSE OF REVIEW Large vessel vasculitides (LVVs) are inflammatory conditions of the wall of large-sized arteries, mainly represented by giant cell arteritis (GCA) and Takayasu arteritis (TA). The inflammatory process within the vessel wall can lead to serious consequences such as development of aneurysms, strokes and blindness; therefore, early diagnosis and follow-up of LVV are fundamental. However, the arterial wall is poorly accessible and blood biomarkers are intended to help physicians no...
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#1Paride FenaroliH-Index: 4
#2Federica MaritatiH-Index: 13
Last. Augusto Vaglio (UniFI: University of Florence)H-Index: 42
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PURPOSE OF THE REVIEW We aim to review the most relevant diagnostic features and treatment options of retroperitoneal fibrosis, in order to provide a useful guide for clinical practice. RECENT FINDINGS The recent literature highlights the role of imaging studies such as computed tomography, magnetic resonance imaging and positron emission tomography as useful tools for the diagnosis of retroperitoneal fibrosis, with retroperitoneal biopsy being reserved to atypical cases. The treatment approach ...
1 CitationsSource
#1Arthur Weinstein (LLU: Loma Linda University)
#1Arthur Weinstein (LLU: Loma Linda University)H-Index: 43
Last. Debra J Zack (AmeriCorps VISTA)
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PURPOSE OF REVIEW Complement activation is a key event in the pathogenesis of tissue inflammation and injury in systemic lupus erythematosus (SLE). This review is aimed at comparing the usefulness of measurement of complement proteins in serum/plasma (C3, C4) to complement activation (split) products in plasma and on circulating blood cells for SLE diagnosis, disease monitoring, and prognosis. RECENT FINDINGS Complement split products, C3dg, iC3b, and C4d, are elevated in SLE, and C3dg/C3 and iC...
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#1Jessica E. Ackerman (URMC: University of Rochester Medical Center)H-Index: 6
#2Katherine T. Best (URMC: University of Rochester Medical Center)H-Index: 5
Last. Alayna E. Loiselle (URMC: University of Rochester Medical Center)H-Index: 19
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PURPOSE OF REVIEW This review seeks to provide an overview of the role of inflammation and metabolism in tendon cell function, tendinopathy, and tendon healing. We have summarized the state of knowledge in both tendon and enthesis. RECENT FINDINGS Recent advances in the field include a substantial improvement in our understanding of tendon cell biology, including the heterogeneity of the tenocyte environment during homeostasis, the diversity of the cellular milieu during in vivo tendon healing, ...
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#1Alojzija HočevarH-Index: 16
#2M. Tomšič (Ljubljana University Medical Centre)H-Index: 20
Last. Katja Perdan Pirkmajer (University of Ljubljana)H-Index: 1
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PURPOSE OF THE REVIEW Polyarteritis nodosa is a rare disease characterized by the necrotizing inflammation of medium-sized arteries. Different etiopathogenetic and clinical variants of the disease have been recognized over the past decades. In the present paper, we review the clinical features, diagnosis, and treatment of the different subtypes of the disease. RECENT FINDINGS The diagnosis of polyarteritis nodosa is primarily based on clinical findings, imaging, and histopathological investigati...
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#1A Charras (University of Liverpool)
#2Eve Smith (University of Liverpool)H-Index: 9
Last. Christian M. Hedrich (University of Liverpool)H-Index: 34
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PURPOSE OF REVIEW Juvenile-onset systemic lupus erythematosus ((j)SLE) is an autoimmune/inflammatory disease that results in significant damage and disability. When compared to patients with disease onset in adulthood, jSLE patients exhibit increased disease activity, damage and require more aggressive treatments. This manuscript summarises age-specific pathogenic mechanisms and underscores the need for age group-specific research, classification and treatment. RECENT FINDINGS Genetic factors pl...
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