in Vivo
Papers 5,060
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#1Afrodite Sialakouma (DUTH: Democritus University of Thrace)
#2Ioannis Karakasiliotis (DUTH: Democritus University of Thrace)H-Index: 5
Last. Byron Asimakopoulos (DUTH: Democritus University of Thrace)H-Index: 20
view all 5 authors...
Background/aim null Preimplantation genetic testing (PGT) for chromosomal screening, based on embryo biopsy, has significant limitations. Cell-free DNA (cf-DNA) has been detected in spent culture medium (SCM), opening new horizons for the development of non-invasive PGT (ni-PGT). In this study, we evaluated the diagnostic performance of ni-PGT for aneuploidy (niPGT-A), comparing the results of trophectoderm biopsies (TE) and respective SCM from individually cultured embryos via Next Generation S...
#1Po-Hsu Su (Memorial Hospital of South Bend)
#2Shun-Wen Hsueh (Memorial Hospital of South Bend)H-Index: 4
Last. Ya-Wen Ho (CGU: Chang Gung University)H-Index: 2
view all 12 authors...
BACKGROUND/AIM Cisplatin with 5-fluouracil (Cis/5Fu) and paclitaxel with carboplatin (Pac/Car) are common regimens used in concurrent chemoradiotherapy (CCRT) for patients with locally advanced esophageal cancer (EC). Here, we aimed to compare the survival outcomes and treatment-related toxicities between these regimens in neoadjuvant CCRT in patients with locally advanced EC. PATIENTS AND METHODS One hundred and thirty-six patients with locally advanced EC (98% squamous cell carcinoma) were pro...
#1Mariela Arellano-Rodríguez (UANL: Universidad Autónoma de Nuevo León)H-Index: 3
#2Pablo Zapata-Benavides (UANL: Universidad Autónoma de Nuevo León)H-Index: 14
Last. Cristina Rodríguez-Padilla (UANL: Universidad Autónoma de Nuevo León)H-Index: 25
view all 10 authors...
Background/aim null Wilms' tumor 1 (WT1) is involved in the development of the urogenital system and is expressed in podocytes throughout life. Inflammation of renal glomeruli causes renal damage-induced nephrotic syndrome and steroid-resistant nephrotic syndrome have mutations in the WT1 gene. The aim of this work was to determine if the inflammatory process modulates the expression and localization of WT1 in podocytes that cause kidney damage using lipopolysaccharide (LPS)-treated mice as a se...
#1Ciprian BolcaH-Index: 10
Last. Nicolae Bacalbasa (Carol Davila University of Medicine and Pharmacy)H-Index: 12
view all 16 authors...
BACKGROUND/AIM Thymic lipofibroadenoma is a benign growth of unknown etiology extremely rarely described in the literature, morphologically resembling lipofibroadenoma of the breast. The diagnosis is usually a postoperative surprise and is made by the anatomopathologist. Surgical resection is curative. CASE REPORT The presented case is the first reported in a woman, to date. The patient was successfully submitted to surgery and complete resection of the giant intrathoracic tumor was performed. T...
#1Maria Dimou (National and Kapodistrian University of Athens)H-Index: 13
#2Aikaterini Bitsani (National and Kapodistrian University of Athens)H-Index: 2
Last. Theodoros P. Vassilakopoulos (National and Kapodistrian University of Athens)H-Index: 36
view all 5 authors...
Background null Failure after CD19-directed chimeric antigen receptor (CAR) T-cell therapy for patients with large B-cell B non-Hodgkin lymphoma, especially when it happens early, is an emerging clinical problem. There are no specific recommendations and therefore treatment of these patients remains empiricaI. Immune checkpoint inhibitors are becoming a therapeutic option for these patients. null Case report null We present a case of a primary mediastinal large B-cell lymphoma who experienced re...
#1Yasukata Ohashi (Toho University)H-Index: 1
#2Megumi YatabeH-Index: 1
view all 12 authors...
Background/aim null The importance of compliance with National Comprehensive Cancer Network (NCCN) guidelines for preventing varicella-zoster virus reactivation (VZVr) in multiple myeloma (MM) in a clinical setting has not been well investigated. null Patients and methods null We retrospectively studied the clinical characteristics and outcomes of 118 patients with MM treated with proteasome inhibitors. null Results null Thirty-nine episodes of VZVr were observed in 37 patients (VZVr group). The...
#1Yosuke Atsumi (YCU: Yokohama City University)H-Index: 4
#2Shinnosuke Kawahara (YCU: Yokohama City University)H-Index: 1
Last. Hiroshi Tamagawa (YCU: Yokohama City University)H-Index: 11
view all 13 authors...
AIM Recent studies have reported that the albumin-to-globulin ratio (AGR) may be a useful inflammatory-nutritional biomarker to predict postoperative complications and poor prognosis in various types of patients with cancer. However, its prognostic value in patients with esophageal cancer is still unclear. We aimed to examine the utility of the AGR for predicting the short- and long-term outcomes in patients with esophageal cancer who underwent curative resection. PATIENTS AND METHODS This was a...
#1Kazuyuki Hamada (Showa University)H-Index: 1
#2Yusuke Aoki (UCSD: University of California, San Diego)H-Index: 2
Last. Robert M. Hoffman (UCSD: University of California, San Diego)H-Index: 117
view all 10 authors...
Background/aim null Triple-negative matrix-producing breast carcinoma (MPBC) is rare, recalcitrant, and highly aggressive. The present study aimed to determine the efficacy of tumor-targeting leucine-arginine auxotroph Salmonella typhimurium (S. typhimurium) A1-R on a triple-negative MPBC in a patient-derived orthotopic xenograft (PDOX) model. null Materials and methods null The PDOX MPBC model was established in the left second mammary gland of nude mice by surgical orthotopic implantation (SOI...
#1Amitava Mukherjee (University of Pittsburgh)H-Index: 19
#2Michael W. Epperly (University of Pittsburgh)H-Index: 61
Last. Luis A. Ortiz (University of Pittsburgh)H-Index: 34
view all 8 authors...
Background/aim null The role of senescence and bone marrow-derived cells in silica-induced pulmonary fibrosis is unknown. null Materials and methods null C57BL/6HNsd, p16+/LUC, and tdTOMp16+ mice were intratracheally injected with 200 mg/kg crystalline silica or irradiated (20 Gy) to the thoracic cavity and followed for the development of lung fibrosis. null Results null The p16+/LUC mice demonstrated senescence by day 7 after silica exposure. C57BL/6 mice exposed to silica demonstrated upregula...
#1Kyung Jin Choi (SKKU: Sungkyunkwan University)
#2Yu-Yon KimH-Index: 4
Last. Hyung Sik Kim (SKKU: Sungkyunkwan University)H-Index: 72
view all 7 authors...
BACKGROUND/AIM Using a rat model of collagen-induced arthritis (CIA), we evaluated the therapeutic effects of HM71224 (BTKi), as well as the drug-drug interactions in combined therapy with methotrexate (MTX) based on both drugs' pharmacological role in immune regulation and antiinflammation. MATERIALS AND METHODS Arthritis in rats was induced using type II collagen and incomplete Freund's adjuvant. The therapeutic effects of HM71224 (alone or in combination with MTX) were evaluated by arthritis ...
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