Biochemistry Research International
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#1Jonathan Katsukunya (UZ: University of Zimbabwe)
#2Rumbidzai Makurira (UZ: University of Zimbabwe)
Last. Stanley Mukanganyama (UZ: University of Zimbabwe)H-Index: 15
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Treatment of infections caused by S. aureus has become a challenge due to the emergency of resistant strains. Ozoroa reticulata root extracts have been used in traditional medicine to treat throat and chest pains in Zimbabwe. The objective of the study was to determine the effects of O. reticulata root bark extracts on the production of extracellular proteases by S. aureus. The root barks were collected, dried, and crushed into powder. To obtain different phytoconstituents, plant extractions wer...
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Several studies have demonstrated that age, comorbidities, and abnormalities in different clinical biomarkers can be important to understand disease severity. Although clinical features of COVID-19 have been widely described, the assessment of alterations of the most common biochemical markers that are reported in patients with COVID-19 still has not been well established. Here, we report clinical and blood biochemical indicators of 100 patients with COVID-19. Throat-swab upper respiratory sampl...
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#1X. E. Mabasa (UNIVEN: University of Venda)
#2L. M. Mathomu (UNIVEN: University of Venda)
Last. M. T. Sigidi (UNIVEN: University of Venda)
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Momordica balsamina (M. balsamina) is a medicinal herb comprising health-promoting secondary metabolites. This study was aimed to profile bioactive compounds in the methanolic extract of M. balsamina leaves using molecular spectroscopic (UV-Vis and FTIR) and hyphenated chromatographic (UHPLC-qTOF-MS) techniques and evaluate the biological (in vitro anti-inflammatory and cytotoxicity) activities of the extract. The preliminary phytochemical screening tests revealed the presence of cardiac glycosi...
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#1Jun Yang (HKU: University of Hong Kong)H-Index: 1
#2Ying Zhang (HKU: University of Hong Kong)
Last. Shaohua Wang (University of South China)H-Index: 1
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Background. Neuroblastoma is a malignant neuroendocrine tumor from the sympathetic nervous system, the most common extracranial tumor in children. Identifying potential prognostic markers of neuroblastoma can provide clues for early diagnosis, recurrence, and treatment. Methods. RNA sequence data and clinical features of 147 neuroblastomas were obtained from the TARGET (Therapeutically Applicable Research to Generate Effective Treatments project) database. Application weighted gene coexpression ...
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#1Ji-Gan WangH-Index: 1
#2Zhi-Juan Zhong (HMU: Hainan Medical University)H-Index: 1
Last. Yu-Li HuangH-Index: 1
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Background. This study aimed to describe the clinical symptoms, laboratory findings, treatment, and outcomes of coronavirus disease 2019-related multisystem inflammatory syndrome in children to provide a reference for clinical practice. Methods. We employed a literature search of databases such as PubMed, Web of Science, EMBASE, and Johns Hopkins University for articles on COVID-19-related multisystem inflammatory syndrome in children published between April 1, 2020, and January 15, 2021. High-q...
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#1Alexander M. Zakharenko (Far Eastern Federal University)H-Index: 17
#2Mayya Razgonova (Far Eastern Federal University)H-Index: 4
Last. Kirill S. GolokhvastH-Index: 21
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The plant Rhodiola rosea L. of family Crassulaceae was extracted using the supercritical CO2-extraction method. Several experimental conditions were investigated in the pressure range of 200–500 bar, with the used volume of cosolvent ethanol in the amount of 1% in the liquid phase at a temperature in the range of 31–70°C. The most effective extraction conditions are pressure 350 bar and temperature 60°C. The extracts were analyzed by HPLC with MS/MS identification. 78 target analytes were isolat...
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#1Seyyed Mojtaba Mousavi (Shiraz University of Medical Sciences)H-Index: 21
#2Seyyed Alireza Hashemi (UBC: University of British Columbia)H-Index: 22
Last. Gity Behbudi (UMA: University of Mohaghegh Ardabili)H-Index: 3
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Nowadays, pollution of the environment is a huge problem for humans and other organisms’ health. Conventional methods of pollutant removal like membrane filtration or ion exchange are not efficient enough to lower the number of pollutants to standard levels. Biological methods, because of their higher efficiency and biocompatibility, are preferred for the remediation of pollutants. These cost-effective and environment-friendly methods of reducing pollutants are called bioremediation. In bioremed...
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The volatile compounds of the fruit and leaf essential oils of the African star fruit, Chrysophyllum albidum G. Don, were characterized by gas chromatography-mass spectrometry in this study. The antimicrobial, antibiofilm, and antioxidant activities of the essential oils were also investigated. Thirty-five and thirty-four compounds, representing 97.84% and 97.87%, were identified in the leaf and fruit essential oils, respectively. The antimicrobial activity of the oils was evaluated in vitro aga...
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Introduction Chronic kidney disorder is a main public health concern. Inflammatory processes and oxidative stress are common in end-stage renal disease patients. We aimed to evaluate the effect of the hydroalcoholic extract of watercress (WC) on the inflammatory cytokines and protein carbonyl (PCO) contents in chronic hemodialysis patients. Methods This was a double-blind randomized clinical trial performed on 46 hemodialysis patients. The participants were randomly divided into two groups: inte...
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Introduction. Glioblastoma is the most malignant brain tumor with different therapeutic protocols, including surgery, radiotherapy, and chemotherapy. Substance P (SP), a peptide released by sensory nerves, increases cellular excitability by activating the neurokinin-1 receptor (NK1R) in several human tumor cells. Aprepitant is a potent and long-lasting NK1R antagonist, considered a new agent for inhibiting proliferation and induction of apoptosis in malignant cells. This study aimed to evaluate ...
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