Experimental and Molecular Pathology
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#1Xingzhe Liu (Yanbian University)H-Index: 1
#2Huazi Li (Qingdao University)
Last. Yanhua Xuan (Yanbian University)H-Index: 6
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Abnormal metabolism and uncontrolled angiogenesis are two important characteristics of malignant tumors. Although HBXIP is known to be associated with a poor prognosis for bladder cancer (BC), its effects on glycolysis and angiogenesis in BC have not been investigated. BC prognosis and relative gene expression of HBXIP were analyzed using the GEPIA, UALCAN, and STRING databases. BC cell angiogenesis and glycolysis were assessed by vasculogenic mimicry and glycolysis assay. Human umbilical vein e...
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#1Negar BidarH-Index: 3
#2Tayebeh Rezaei (Tabriz University of Medical Sciences)H-Index: 4
Last. Behzad Baradaran (Tabriz University of Medical Sciences)H-Index: 41
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Gastric cancer (GC) is one of the leading causes of cancer-related death worldwide, due to poor prognosis and treatment failure; demanding new diagnostic and therapeutic targets. Therefore, in the present study, the methylation and expression status of ZNF677, as a promising tumor suppressor, were investigated in GC. Gene Expression Omnibus (GEO) datasets were used to initially evaluate ZNF677 expression and methylation in GC samples. Confirmation was performed on fifty internal samples, includi...
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#1Milad BastamiH-Index: 12
#2Andrea Masotti (Boston Children's Hospital)H-Index: 31
Last. Ziba Nariman-Saleh-Fam (Tabriz University of Medical Sciences)H-Index: 12
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Abstract null null MicroRNAs (miRNAs) have emerged as a critical component of regulatory networks that modulate and fine-tune gene expression in a post-transcriptional manner. The microRNA-196 family is encoded by three loci in the human genome, namely hsa-mir-196a-1, hsa-mir-196a-2, and hsa-mir-196b. Increasing evidence supports the roles of different components of this miRNA family in regulating key cellular processes during differentiation and development, ranging from inflammation and differ...
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#1Carlos Gustavo Sakuno Rosa (ULBRA: Universidade Luterana do Brasil)H-Index: 2
#2Josieli Raskopf Colares (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 7
Last. Norma Possa Marroni (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 33
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Abstract null null Sarcopenia is one of the most common features of cirrhosis, contributing to morbidity and mortality in this population. We aimed to evaluate the effect of melatonin (MLT) and exercise (EX) on the quadriceps muscle in rats with biliary cirrhosis induced by bile duct ligation (BDL). We used 48 males (mean weight = 300 g), divided into eight groups. A 20 mg/Kg MLT dose was administered via i.p. (1 x daily), and the EX, the animals were set to swim in couples for 10 min each day. ...
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#1Ya-Wen Wang (SDU: Shandong University)H-Index: 3
#2Yao Xu (SDU: Shandong University)
Last. Kai Zhang (SDU: Shandong University)H-Index: 22
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BACKGROUND AND OBJECTIVES Increasing studies have shown that circular RNAs (circRNAs) have great diagnostic potential in cancer. Here, we examined whether the blood circRNAs could be promising candidates as diagnostic biomarkers in breast cancer. METHODS Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was performed to detect levels of five circRNAs (circ_0000501, circ_0000745, circ_0001531, circ_0001640 and circ_0001978) in 129 patients with breast cancer, 19 patients with...
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Abstract null null This review explores the developments leading up to the establishment of the cell theory and cellular pathology and their subsequent refinements and applications while focusing on the individuals who have made seminal advances in the field. The links between cell biology, cell pathology and cell injury research are emphasized. Recognition also is given to the importance of technological advances in microscopy, histology, biochemical and molecular methods for discovery in cell ...
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ADAMs are members of the metzincin family of zinc-dependent metalloproteinases, which play a key role in the proteolytic degradation of the extracellular matrix to invade cells. It is well known that ADAMs are involved in regulating the invasion of trophoblast cells. But the function and underlying mechanism of ADAM7 in trophoblast cells is still unknown. ADAM7 knockdown strongly inhibited HTR-8 and B6Tert-1 cells proliferation, migration and invasion, while ADAM7 overexpression reversed. The ex...
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#1Zhiwei LiH-Index: 2
#2Xiaoli CuiH-Index: 2
Last. Xiansong ChengH-Index: 1
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Abstract null null This paper was aimed at exploring the correlation of long non-coding RNA (lncRNA)-ABHD11 Antisense RNA1 (ABHD11-AS1) with the poor prognosis of patients with papillary thyroid carcinoma (PTC) and at investigating its effects on the survival of PTC cells. Serum was respectively collected from 64 PTC patients who were admitted to our hospital (PTC group) and from 50 healthy controls who underwent physical examinations (HC group) both from April 2011 to April 2015. The expression...
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Abstract Objective MicroRNA (miR)-93 has been proven to mediate the initiation and progression of colorectal carcinoma (CRC); however, the mechanisms by which miR-93 mediates CRC development need deeper elucidation. The present study is designed to investigate the association between miR-93 and high mobility group box 3 (HMGB3), as well as the functions of miR-93, in CRC. Methods miR-93 expression was quantified by RT-qPCR. CRC cells were transfected or cotransfected with miR-93 mimic, miR-93 in...
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