OBJECTIVE Preeclampsia (PE) is one of common pregnancy diseases, which has seriously threatened the health of the gravidas. Although upregulated miR-269-3p has been found in the placentas of the patients with PE, the regulation mechanisms of miR-296-3p remain unclear. PATIENTS AND METHODS In this study, the placentas of the patients and normal gravidas were used to observe the difference in miR-296-3p expression level, and HTR-8/Svneo and JAR cells were used to investigate the role of miR296-3p ...
The von Meyenburg complex (VMC) comprises of the bile duct hamartomas (BHs). VMCs are benign biliary malformations that originate from the disorganization of the small intrahepatic bile ducts. VMCs typically cause no symptoms or disturbances in the liver function; thus, in most instances, they are diagnosed incidentally. However, on some occasions, they are difficult to differentiate from other liver lesions, in particular from small liver metastases; imaging studies are usually noncontributory,...
OBJECTIVE Coronary computed tomography angiography (CCTA) is becoming increasingly useful for the diagnosis of coronary artery disease (CAD). Coronary calcium score (CCS), epicardial fat volume (EFV), and number of coronary plaques (NoP) add important information for the risk stratification and prognosis prediction of these patients. However, evidence about their ability to predict obstructive CAD is limited. We sought to evaluate the ability of CCTA parameters in predicting obstructive CAD. PAT...
OBJECTIVE The aim of this study is to analyze the disease prevalence of a rural African village and discuss how to maximize the outcomes of health projects. The analysis was based on electronic medical records (EMR) at a clinic in Bududa, Uganda. The installation of EMR in such a low-resource setting enabled efficient statistical analysis. MATERIALS AND METHODS Medical records from January 2013 to September 2017 were analyzed. During the study period, the top five disease categories diagnosed in...
OBJECTIVE Proton Pump Inhibitors (PPIs) and traditional antacids are the common standard set of therapy for the management of gastroesophageal reflux disease (GERD) symptoms. The aim of the current study was to evaluate efficacy and safety of a novel galactomannan-based liquid formulation in reducing typical GERD symptoms in patients not taking PPIs. PATIENTS AND METHODS This was a single-center, randomized, double-blind, placebo-controlled study. Sixty patients met the eligibility criteria and ...
OBJECTIVE The aim of the study was to perform a systematic literature search and conduct a meta-analysis of studies comparing clinical and functional outcomes of open reduction with internal fixation (ORIF) using a volar plate and closed reduction with casting for distal radius fracture in older adults (≥60 years of age). MATERIALS AND METHODS A comprehensive electronic search was done for PubMed, Scopus, CENTRAL (Cochrane Central Register of Controlled Trials), and Google scholar databases. Onl...
OBJECTIVE This prospective case study investigated the new therapeutic paradigm of autologous gold-induced immunotherapy (Go ACT®) in the treatment of pollen-based allergies. The safety and clinical efficacy of Go ACT® were investigated by assessing patients in the first pollen season following treatment with Go ACT®. PATIENTS AND METHODS In this prospective case study, patients were enrolled who had a proven pollen allergy and had been previously unsuccessfully treated with standard medication....
OBJECTIVE Depression is one of the most commonly occurring psychiatric comorbidities in patients suffering from inflammatory bowel disease (IBD). This study aims to determine prevalence and risk factors for the more severe symptoms of depression (DP) in IBD patients on intravenous biological therapy (IBT). PATIENTS AND METHODS The study consisted of 90 IBD patients who completed a Patient Health Questionnaire-9 (PHQ9) to detect symptoms of depression. Demographic information and disease characte...
Objective null Programmed death ligand-1 (PD-L1) is expressed on tumor cells and macrophages. The detection of PD-L1 expression in cancer and the treatment by targeting the PD-L1/programmed death-1 (PD-1) are of great clinical significance. This work aims to screen the aptamers with high affinity and specificity for recombinant human PD-1 (rhPD-1)/recombinant human PD-L1 extracellular domain (rhPD-L1). null Materials and methods null In this study, we have expressed, purified, prepared, and iden...