Environmental Toxicology and Pharmacology
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4.86
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Evidence indicates that Benzo(a)pyrenediol-epoxide (BPDE) can damage lung cells, resulting in carcinogenesis with complex mechanisms. We aimed to explore the genes and pathway variations in this process. First, the key gene was screened out and identified through data mining, and then, it was in turn validated by bioinformatics analysis and experimental methods. Consequently, 106 up-regulated and 260 down-regulated differentially expressed genes were yielded, which were enriched in various pathw...
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#1Xiang Zeng (Xinxiang Medical University)H-Index: 5
#2Dongling Liu (Xinxiang Medical University)H-Index: 2
Last. Weidong Wu (Xinxiang Medical University)H-Index: 25
view all 3 authors...
Abstract null null Fine particulate matter (PM2.5) is the first leading environmental risk factor for death according to the Global Burden of Disease Study 2019. Children are in a pivotal window stage of growth and development, and one of the most sensitive and vulnerable groups when they are exposed to PM2.5. E-waste refers to the abandoned electrical or electronic equipment. Informal e-waste dismantling activities, such as heating, burning, and roasting, will release a large number PM2.5 into ...
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#1Jenna Wiegand (UCR: University of California, Riverside)
#2Vanessa Cheng (UCR: University of California, Riverside)H-Index: 3
Last. David C. Volz (UCR: University of California, Riverside)H-Index: 27
view all 5 authors...
Abstract null null Triphenyl phosphate (TPHP) is an organophosphate ester-based plasticizer and flame retardant. The objective of this study was to identify the potential role of epidermal ionocytes in mediating TPHP-induced pericardial edema within zebrafish embryos. Exposure to TPHP from 24 to 72 h post fertilization (hpf) resulted in a significant increase in pericardial edema and the number of ionocytes at 72 hpf relative to time-matched embryos treated with vehicle. In addition, co-exposure...
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#1P. Goswami (AcSIR: Academy of Scientific and Innovative Research)
#2Sanjoy Gupta (AcSIR: Academy of Scientific and Innovative Research)H-Index: 2
Last. Sandeep Kumar Singh (AcSIR: Academy of Scientific and Innovative Research)H-Index: 10
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#1Nour A. Al-Sawalha (JUST: Jordan University of Science and Technology)H-Index: 11
#2Roba Bdeir (Jadara University)
Last. Alan Shihadeh (AUB: American University of Beirut)H-Index: 46
view all 8 authors...
Electronic cigarettes (e-cigarettes) have been marketed as a less lethal substitute for smoking traditional cigarettes. This study aims to investigate the impact of e-cigarettes aerosol exposure on lactating dams and pups, whose dams were exposed. Lactating dams received fresh air (control) or e-cigarettes aerosol during lactation (day 4-21). Maternal exposure to e-cigarettes aerosol during lactation induced significant reduction (P < 0.0001) in the fat content of the milk and serum Leptin level...
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#1Michael W. Duffel (UI: University of Iowa)H-Index: 28
#2Kristopher M. Tuttle (UI: University of Iowa)H-Index: 2
Last. Larry W. Robertson (UI: University of Iowa)H-Index: 61
view all 4 authors...
Abstract null null Polychlorinated biphenyls (PCBs) are persistent environmental contaminants that continue to be of concern due to their varied toxicities. Upon human exposure, many PCBs with lower numbers of chlorine atoms are metabolized to hydroxylated derivatives (OH-PCBs), and cytosolic sulfotransferases can subsequently catalyze the formation of PCB sulfates. Recent studies have indicated that PCB sulfates bind reversibly with a high affinity to human serum proteins, and that they are als...
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#1Sara E. Gallego-Ríos (UdeA: University of Antioquia)
#2Gustavo A. Peñuela (UdeA: University of Antioquia)H-Index: 27
Last. Emma Martínez-López (University of Murcia)H-Index: 21
view all 3 authors...
The evaluation of toxic effects in stressful environmental conditions can be determined through the imbalance between exogenous factors (environmental contaminants) and enzymatic and non-enzymatic defenses in biological systems. The use of fish for the identification of alterations in biochemical biomarkers provides a comprehensive vision of the effects that pharmaceutical products cause in the aquatic ecosystem, as they are organisms with high sensitivity to contaminants, filtering capacity, an...
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Periodontitis is a most prevalent and infectious multifactorial inflammatory disease and is characterized by the progressive destruction of the tooth-supporting tissues. Porphyromonas gingivalis, a Gram‑negative oral anaerobe, mainly causes periodontitis and it is one of the most important risk factors responsible for aggravation of existing systemic diseases. Several experimental and clinical studies have shown the positive association between periodontitis and different forms of liver disease....
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#1Paolo Cocci (University of Camerino)H-Index: 12
#2Gilberto Mosconi (University of Camerino)H-Index: 25
Last. Francesco Alessandro Palermo (University of Camerino)H-Index: 17
view all 3 authors...
The tributyltin (TBT)-mediated induction of imposex in marine snails is considered a common mechanism of endocrine disruption through the retinoid X receptor (RXR)-dependent pathway. However, there is evidence that regulation of RXR also relates to metabolic processes, differentiation, apoptosis, and embryonic development, playing a key role in molluscan neuronal differentiation and organogenesis. In this regard, very little is known about the gastropod Tritia mutabilis especially in relation to...
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