American Journal of Nephrology
Papers 4,242
1 page of 425 pages (4,242 results)
#1Benjamin K.A. Thomson (JHU: Johns Hopkins University)
#2Nathan G. Pilkey (Queen's University)H-Index: 1
Last. Rachel M. Holden (Queen's University)H-Index: 23
view all 4 authors...
INTRODUCTION Patients with end-stage renal disease (ESRD) have high rates of cardiac valvulopathy but can develop contraindications for vitamin K antagonist (VKA) therapy. We explored the evidence for alternative anticoagulation strategies in patients with ESRD with a contraindication for VKA therapy. METHODS A scoping review was completed, searching MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Web of Science, and Conference abstracts from inception to March 30, 2021. The stu...
#1Hai Ning Wee (NUS: National University of Singapore)H-Index: 1
#2Jianjun Liu (KTPH: Khoo Teck Puat Hospital)H-Index: 122
Last. Su Chi Lim (NUS: National University of Singapore)H-Index: 37
view all 5 authors...
Background null The kynurenine pathway (KP) is the major catabolic pathway for tryptophan degradation. The KP plays an important role as the sole de novo nicotinamide adenine dinucleotide (NAD+) biosynthetic pathway in normal human physiology and functions as a counter-regulatory mechanism to mitigate immune responses during inflammation. Although the KP has been implicated in a variety of disorders including Huntington's disease, seizures, cardiovascular disease, and osteoporosis, its role in r...
#1Shou-Liang Hu (YU: Yangtze University)H-Index: 4
#2Dan Wang (YU: Yangtze University)H-Index: 3
Last. Jun-zhang Cheng (YU: Yangtze University)H-Index: 4
view all 8 authors...
Background null Inflammation appears to be at the biological core of arteriovenous fistula (AVF) dysfunction, and the occurrence of AVF dysfunction is related to high death and disability in hemodialysis (HD) patients. Despite several studies on the correlations between AVF dysfunction and inflammatory indicators, how AVF dysfunction is related to the monocyte-to-lymphocyte ratio (MLR) is much unclear. We hypothesize that preoperative MLR is associated with AVF dysfunction in Chinese HD patients...
#1Ying Zhu (NMU: Nanjing Medical University)
#2Yun Fan (NMU: Nanjing Medical University)
Last. Caihong Zeng (NU: Nanjing University)H-Index: 36
view all 11 authors...
Introduction null Transplant glomerulopathy (TG) is a morphological lesion resulting from chronic glomerular endothelium injury, and it is strongly associated with poor graft survival. TG coexisting with focal segmental glomerulosclerosis (FSGS) can be found in renal allograft biopsies, but few related studies are available. null Methods null Consecutive kidney transplant recipients with biopsy-proven TG were studied retrospectively. Patients concomitant with FSGS were identified and compared wi...
#1Muh Geot Wong (George Institute for Global Health)H-Index: 18
#2Jicheng Lv (PKU: Peking University)H-Index: 37
Last. Vlado Perkovic (George Institute for Global Health)H-Index: 94
view all 27 authors...
INTRODUCTION Despite optimal current care, up to 30% of individuals suffering from immunoglobulin A nephropathy (IgAN) will develop kidney failure requiring dialysis or kidney transplantation. The Therapeutic Evaluation of STeroids in IgA Nephropathy Global (TESTING) study was designed to assess the benefits and risks of steroids in people with IgAN. We report the trial design as well as the baseline characteristics of study participants. METHODS It is an investigator-initiated, multicenter, dou...
#1Erin F. Barreto (Mayo Clinic)H-Index: 11
#2Diana J. Schreier (Mayo Clinic)H-Index: 3
Last. Andrew D. Rule (Mayo Clinic)H-Index: 46
view all 11 authors...
INTRODUCTION Acute kidney injury (AKI) affects 20% of hospitalized patients and worsens outcomes. To limit complications, post-discharge follow-up and kidney function testing are advised. The objective of this study was to evaluate the frequency of follow-up after discharge among AKI survivors. METHODS This was a population-based cohort study of adult Olmsted County residents hospitalized with an episode of stage II or III AKI between 2006 and 2014. Those dismissed from the hospital on dialysis,...
#1Hiroyasu Yamamoto (Jikei University School of Medicine)H-Index: 20
#2Kiyoshi Nobori (Bayer)H-Index: 2
Last. Tadao Akizawa (Showa University)H-Index: 65
view all 6 authors...
#1Qurat-ul-ain Jelani (Yale University)H-Index: 5
#2Fiorella Llanos-Chea (Yale University)H-Index: 3
Last. Carlos Mena-Hurtado (Yale University)H-Index: 11
view all 11 authors...
INTRODUCTION Guideline-directed medical therapy (GDMT) is imperative to improve cardiovascular and limb outcomes for patients with critical limb ischemia (CLI), especially amongst those at highest risk for poor outcomes, including those with comorbid chronic kidney disease (CKD). Our objective was to examine GDMT prescription rates and their variation across individual sites for patients with CLI undergoing peripheral vascular interventions (PVIs), by their comorbid CKD status. METHODS Patients ...
#1Avi Goldberg (HUJI: Hebrew University of Jerusalem)
Last. Richard J. Johnson (University of Colorado Anschutz Medical Campus)H-Index: 161
view all 7 authors...
Hyperuricemia predicts the development of chronic kidney disease (CKD) and metabolic complications, but whether it has a causal role has been controversial. This is especially true given the 2 recently conducted randomized controlled trials that failed to show a benefit of lowering uric acid in type 1 diabetes-associated CKD and subjects with stage 3-4 CKD. While these studies suggest that use of urate-lowering drugs in unselected patients is unlikely to slow the progression of CKD, there are su...
#1Alexander B. Sellier (Saarland University)H-Index: 2
#2Sarah Seiler-Mußler (Saarland University)H-Index: 5
Last. Gunnar H. Heine (Saarland University)H-Index: 46
view all 7 authors...
INTRODUCTION High plasma fibroblast growth factor 23 (FGF-23) predicts cardiovascular events in chronic kidney disease (CKD) patients. Experimental evidence suggests FGF receptor 4 (FGFR4) activation by FGF-23, and deficiency of the soluble form of its co-receptor Klotho promotes left-ventricular hypertrophy (LVH). To evaluate the clinical relevance of these findings, a Mendelian randomization study analyzed the association of genetic variants of FGFR4 and Klotho with echocardiographic parameter...
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