Brigitta Buttari
Istituto Superiore di Sanità
Innate immune systemPeripheral blood mononuclear cellImmunoglobulin EPathologyAntigenAntibodyProinflammatory cytokineChemistryEpitopeImmunologyT cellOxidative stressInflammationEchinococcus granulosusCytokineEndothelial dysfunctionMedicineBiologyImmune systemCell biology
93Publications
25H-index
1,894Citations
Publications 93
Newest
#1Bercis Imge UcarH-Index: 4
#1Bercis Imge Ucar (Hacettepe University)
Last. Luciano SasoH-Index: 51
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Ischemia/reperfusion (I/R) injury is associated with substantial clinical implications, including a wide range of organs such as the brain, kidneys, lungs, heart, and many others. I/R injury (IRI) occurs due to the tissue injury following the reestablishment of blood supply to ischemic tissues, leading to enhanced aseptic inflammation and stimulation of oxidative stress via reactive oxygen and nitrogen species (ROS/RNS). Since ROS causes membrane lipids’ peroxidation, triggers loss of membrane i...
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#1Ipek Süntar (Gazi University)H-Index: 25
#2Sümeyra Çetinkaya (Laos Ministry of Agriculture and Forestry)H-Index: 1
Last. Luciano Saso (Sapienza University of Rome)H-Index: 51
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Wound healing involves a series of cellular events in damaged cells and tissues initiated with hemostasis and finally culminating with the formation of a fibrin clot. However, delay in the normal wound healing process during pathological conditions due to reactive oxygen species, inflammation and immune suppression at the wound site represents a medical challenge. So far, many therapeutic strategies have been developed to improve cellular homeostasis and chronic wounds in order to accelerate wou...
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#1Melford C. Egbujor (Renaissance University)H-Index: 1
#2Sarmistha SahaH-Index: 9
Last. Luciano Saso (Sapienza University of Rome)H-Index: 51
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INTRODUCTION Nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway plays a key role in diverse gene expressions responsible for protection against oxidative stress and xenobiotics. Chalcones with a common chemical scaffold of 1,3-diaryl-2-propen-1-one, are abundantly present in nature with a wide variety of pharmacological properties. This review will discuss the interactions of natural and synthetic chalcones with Nrf2 signaling.Areas covered:Chalcones are reportedly found to act...
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#1Chiara Donfrancesco (ISS: Istituto Superiore di Sanità)H-Index: 22
#2Cinzia Lo Noce (ISS: Istituto Superiore di Sanità)H-Index: 10
Last. Pasquale Strazzullo (University of Naples Federico II)H-Index: 66
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Abstract Background and aims Low potassium intake, in addition to high sodium, has been associated with higher risk of hypertension and CVD. The Study assessed habitual potassium intake and sodium/potassium ratio of the Italian adult population from 2008 to 2012 to 2018–2019 based on 24-h urine collection, in the framework of the CUORE Project/MINISAL-GIRCSI/MENO SALE PIU’ SALUTE national surveys. Methods and results Data were from cross-sectional surveys of randomly selected age-and-sex stratif...
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#1Chiara Donfrancesco (ISS: Istituto Superiore di Sanità)H-Index: 22
#2Cinzia Lo Noce (ISS: Istituto Superiore di Sanità)H-Index: 10
Last. Pasquale Strazzullo (University of Naples Federico II)H-Index: 66
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BACKGROUND AND AIMS The WHO Global Action Plan for the Prevention of non-communicable diseases (NCDs) recommends a 30% relative reduction in mean population salt/sodium intake. The study assessed the trend in the habitual salt intake of the Italian adult population from 2008 to 2012 to 2018-2019 based on 24-h urinary sodium excretion, in the framework of the CUORE Project/MINISAL-GIRCSI/MENO SALE PIU' SALUTE national surveys. METHODS AND RESULTS Data were from cross-sectional surveys of randomly...
1 CitationsSource
#1Sarmistha SahaH-Index: 2
#1Sarmistha SahaH-Index: 9
Last. Luciano Saso (Sapienza University of Rome)H-Index: 51
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Inflammation is a key driver in many pathological conditions such as allergy, cancer, Alzheimer's disease, and many others, and the current state of available drugs prompted researchers to explore new therapeutic targets. In this context, accumulating evidence indicates that the transcription factor Nrf2 plays a pivotal role controlling the expression of antioxidant genes that ultimately exert anti-inflammatory functions. Nrf2 and its principal negative regulator, the E3 ligase adaptor Kelch-lik...
17 CitationsSource
Macrophage activation and polarization play a central role in atherosclerotic plaque fate. The M1/M2 activation phenotypes represent two profiles of the macrophage polarization state. During atherosclerosis regression or stabilization, macrophages switch from M1 proinflammatory phenotype to M2 anti-inflammatory reparative one. Here, we investigated whether the natural compound lupeol, a pentacyclic triterpene, induces phenotypical and functional changes in human M1 macrophages and counteracts th...
2 CitationsSource
#1Chiara Donfrancesco (ISS: Istituto Superiore di Sanità)H-Index: 22
#2A. Di Lonardo (ISS: Istituto Superiore di Sanità)H-Index: 1
Last. Luigi Palmieri (ISS: Istituto Superiore di Sanità)H-Index: 32
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#1Chiara Donfrancesco (ISS: Istituto Superiore di Sanità)H-Index: 22
#2Elisabetta Profumo (ISS: Istituto Superiore di Sanità)H-Index: 28
Last. Luigi Palmieri (ISS: Istituto Superiore di Sanità)H-Index: 32
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#1Brigitta Buttari (ISS: Istituto Superiore di Sanità)H-Index: 25
#2Elisabetta Profumo (ISS: Istituto Superiore di Sanità)H-Index: 28
Last. Rachele Riganò (ISS: Istituto Superiore di Sanità)H-Index: 31
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β-Thalassemia is an inherited single gene disorder related to reduced synthesis of the β-globin chain of hemoglobin. Patients with β-thalassemia present variable clinical severity ranging from asymptomatic trait to severe transfusion-dependent anemia and multiple organs complications. Moreover, multiple immune abnormalities are a major concern in β-thalassemia patients. Aberrant neutrophil effector function plays a pivotal role in infection susceptibility in these patients. In severe and persist...
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