Anders D. Børglum
University of Copenhagen
GeneGenome-wide association studyPsychiatryInternal medicineSingle-nucleotide polymorphismPsychologyAlleleGenetic associationAutismBipolar disorderAutism spectrum disorderAttention deficit hyperactivity disorderPopulationGeneticsClinical psychologyMedicineSchizophreniaLocus (genetics)BiologyGenetic architecture
Publications 411
#1Isabell Brikell (KI: Karolinska Institutet)H-Index: 13
Last. T. WergeH-Index: 6
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BackgroundADHD is multifactorial, yet the interplay ADHD polygenic risks scores (ADHD-PRS) and other ADHD associated risk-factors remains relatively unexplored. The aim of this study was to investigate associations, confounding and interactions of ADHD-PRS with birth, somatic and psychosocial risk-factors previously associated with ADHD. null MethodsParticipants came from the Danish iPSYCH2012 case-cohort, including a randomly selected general population sample (N=21,578), and all ADHD cases wit...
#1Veera M. Rajagopal (Lundbeck)H-Index: 10
#2Jinjie Duan (Lundbeck)
Last. Marie Bækvad-Hansen (AU: Aarhus University)H-Index: 13
view all 22 authors...
Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder, with onset in childhood ("childhood ADHD"), and around two thirds of affected individuals will continue to have ADHD symptoms in adulthood ("persistent ADHD"). Age at first diagnosis can vary, and sometimes ADHD is first diagnosed in adulthood ("late-diagnosed ADHD"). null In this study, we analyzed a large Danish population-based case-cohort generated by iPSYCH in order to identify common genetic risk loci and per...
#1Isabell Brikell (Lundbeck)H-Index: 13
#2Theresa Wimberley (AU: Aarhus University)H-Index: 15
Last. Søren DalsgaardH-Index: 35
view all 16 authors...
Objective: Stimulant medications are effective for treating attention deficit hyperactivity disorder (ADHD), yet discontinuation and switch to nonstimulant ADHD medications are common. This study a...
#1Clara Albiñana (Lundbeck)H-Index: 2
#2Jakob GroveH-Index: 51
Last. Bjarni J. Vilhjálmsson (Lundbeck)H-Index: 25
view all 13 authors...
Summary The accuracy of polygenic risk scores (PRSs) to predict complex diseases increases with the training sample size. PRSs are generally derived based on summary statistics from large meta-analyses of multiple genome-wide association studies (GWASs). However, it is now common for researchers to have access to large individual-level data as well, such as the UK Biobank data. To the best of our knowledge, it has not yet been explored how best to combine both types of data (summary statistics a...
#1Veerle PaternosterH-Index: 4
#2Anders Valdemar Edhager (Aarhus University Hospital)H-Index: 4
Last. Jane H. Christensen (Lundbeck)H-Index: 21
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Genetic studies have repeatedly shown that the Bromodomain containing 1 gene, BRD1, is involved in determining mental health, and the importance of the BRD1 protein for normal brain function has been studied in both cell models and constitutive haploinsufficient Brd1+/- mice. Homozygosity for inactivated Brd1 alleles is lethal during embryonic development in mice. In order to further characterize the molecular functions of BRD1 in the brain, we have developed a novel Brd1 knockout mouse model (B...
#1Xueping Liu (Centre for Mental Health)H-Index: 6
#1Xueping Liu (Centre for Mental Health)H-Index: 1
Last. Michael E. Benros (Centre for Mental Health)H-Index: 32
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1 CitationsSource
#1Strom Ni (Humboldt University of Berlin)
#2Jakob Grove (AU: Aarhus University)H-Index: 51
Last. Mattheisen M (Dal: Dalhousie University)H-Index: 1
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Among patients with obsessive-compulsive disorder (OCD), 65-85% manifest another psychiatric disorder concomitantly or at some other time point during their life. OCD is highly heritable, as are many of its comorbidities. A possible genetic heterogeneity of OCD in relation to its comorbid conditions, however, has not yet been exhaustively explored. We used a framework of different approaches to study the genetic relationship of OCD with three commonly observed comorbidities, namely major depress...
#1Mattheisen M (Dal: Dalhousie University)H-Index: 1
#1Manuel Mattheisen (Dal: Dalhousie University)
Last. Anders D. Børglum (AU: Aarhus University)H-Index: 67
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Attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are highly heritable neurodevelopmental disorders with a considerable overlap in their genetic etiology. We dissected their shared and distinct genetic architecture by cross-disorder analyses of large data sets, including samples with information on comorbid diagnoses. We identified seven loci shared by the disorders and the first five genome-wide significant loci differentiating the disorders. All five differenti...
#1Carin A.T.C. Lunenburg (AU: Aarhus University)H-Index: 2
#1Carin A. T. C. Lunenburg (Aarhus University Hospital)
Last. Christiane Gasse (Aarhus University Hospital)H-Index: 28
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Pharmacogenetics aims to improve clinical care by studying the relationship between genetic variation and variable drug response. Large population-based datasets could improve our current understanding of pharmacogenetics from selected study populations. We provide real-world pharmacogenetic frequencies of genotypes and (combined) phenotypes of a large Danish population-based case-cohort sample (iPSYCH2012; data of the Integrative Psychiatric Research consortium). The genotyped sample consists o...
#1Niamh Mullins (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 16
#2Andreas J. Forstner (University of Marburg)H-Index: 5
Last. Ole A. Andreassen (University of Oslo)H-Index: 123
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Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 64 associated genomic loci. Bipolar disorder risk alleles were enriched in genes in synaptic signaling pathways and brain-expressed genes, particularly those with high specificity of expression in neurons of the prefrontal cortex and hippocampus. Significant signal enrichment was found in ge...
9 CitationsSource