Xiaogang Qu
University of Science and Technology of China
Colloidal goldBiophysicsNanomaterialsNanoparticleCatalysisNanotechnologyPhotothermal therapyChemistryMaterials scienceIn vivoCombinatorial chemistryBiocompatibilityDrug deliveryGrapheneReactive oxygen speciesBacteriaDNABiochemistryG-quadruplexFluorescenceCancer cell
474Publications
106H-index
30.3kCitations
Publications 484
Newest
#1Wenjie Wang (USTC: University of Science and Technology of China)
#2L. Zhang (CAS: Chinese Academy of Sciences)H-Index: 59
Last. Xiaogang Qu (CAS: Chinese Academy of Sciences)H-Index: 106
view all 6 authors...
Abstract null null Metabolically heterogeneous tumors could rely on “metabolic symbiosis” to mutually regulate the access to extracellular nutrients between glycolytic and oxygenated tumor cells for impeding the development of therapies which aim at metabolic vulnerabilities. Herein, a yeast@MOF bioreactor has been designed as a tumor metabolic symbiosis disruptor to deprive the energy supply of both glycolytic and oxygenated tumor cells for the potent inhibition of metabolically heterogeneous t...
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#1Yanjuan Sang (USTC: University of Science and Technology of China)H-Index: 8
#2Qingqing Deng (USTC: University of Science and Technology of China)H-Index: 7
Last. Xiaogang Qu (CAS: Chinese Academy of Sciences)H-Index: 106
view all 8 authors...
Tumor-associated macrophages (TAMs) that infiltrate in most tumor tissues are closely correlated with proliferation and metastasis of tumor cells. Immunomodulation of TAMs from pro-tumorigenic M2 p...
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#1Xiaogang Qu (CAS: Chinese Academy of Sciences)H-Index: 106
#2Haochen Zhang (CAS: Chinese Academy of Sciences)H-Index: 1
Last. Jinsong Ren (CAS: Chinese Academy of Sciences)H-Index: 107
view all 7 authors...
Phototherapy has emerged as a powerful approach for interrupting β-amyloid (Aβ) self-assembly. However, deeper tissue penetration and safer photosensitizers are urgent to be exploited for avoiding damaging nearby normal tissues and improving therapeutic effectiveness. A hydrogen-bonded organic framework (HOF)-based NIR-II photooxygenation catalyst is presented here to settle the abovementioned challenges. By encapsulating the pyridinium hemicyanine dye DSM with a large two-photon absorption (TPA...
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#1Hao Liu (USTC: University of Science and Technology of China)H-Index: 8
#2Yawen You (USTC: University of Science and Technology of China)H-Index: 5
Last. Xiaogang Qu (USTC: University of Science and Technology of China)H-Index: 106
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Off-target toxicity and insufficient hydroxyl radicals (. OH) generation limit the further clinical application of nanozymes in chemodynamic therapy (CDT). Herein, we designed and constructed a microRNA-triggered nanozyme cascade platform for enhanced tumor-specific chemodynamic therapy. The nanozyme-based cascade reaction could be triggered successfully by the high expression of microRNA in cancer cells to generate more . OH, thus exhibiting excellent tumor-specific therapeutic performance. Our...
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#1Jingsheng Niu (USTC: University of Science and Technology of China)H-Index: 4
#2Chuanqi Zhao (USTC: University of Science and Technology of China)H-Index: 28
Last. Xiaogang Qu (USTC: University of Science and Technology of China)H-Index: 106
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#1Jingsheng Niu (USTC: University of Science and Technology of China)H-Index: 4
#2Liangpeng Wang (CAS: Chinese Academy of Sciences)
Last. Xiaogang Qu (USTC: University of Science and Technology of China)H-Index: 106
view all 7 authors...
Bacterial infectious diseases seriously threaten public health and life. The specific interaction between an antibody and its multivalent antigen is an attractive way to defeat infectious disease. However, due to the high expense and strict storage and applied conditions for antibodies, it is highly desirable but remains an urgent challenge for disease diagnosis and treatment to construct artificial antibodies with strong stability and binding ability and excellent selectivity. Herein, we design...
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#1Yan Cheng (CAS: Chinese Academy of Sciences)H-Index: 24
#2Haiyuan Zhang (USTC: University of Science and Technology of China)H-Index: 40
Last. Xiaogang Qu (USTC: University of Science and Technology of China)H-Index: 106
view all 3 authors...
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#1Hongshuang Qin (USTC: University of Science and Technology of China)H-Index: 6
#2Tingting Cui (USTC: University of Science and Technology of China)H-Index: 4
Last. Xiaogang Qu (USTC: University of Science and Technology of China)H-Index: 106
view all 7 authors...
Cancer stem cells (CSCs) play crucial roles in tumor initiation. Amyloid β (Aβ), which is associated with Alzheimer's disease (AD), has been identified to induce cytotoxicity in tumor cells besides brain cells. Herein, we find that oligomeric Aβ1-42 and Aβ1-40 (OAβ1-42 and OAβ1-40) can repress the viability of breast CSCs. Intriguingly, OAβ1-42 and OAβ1-40 preferentially induce the growth arrest of breast CSCs by contrast with the bulk cancer cells. Further studies indicate that OAβ1-42 and OAβ1...
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#1Mengmeng Ma (USTC: University of Science and Technology of China)H-Index: 8
#2Zhenqi Liu (USTC: University of Science and Technology of China)H-Index: 4
Last. Xiaogang Qu (CAS: Chinese Academy of Sciences)H-Index: 106
view all 9 authors...
Clearance of peripheral amyloid-β (Aβ) has been demonstrated particularly promising for overcoming the blood-brain barrier (BBB) hurdle to remove brain-derived Aβ associated with Alzheimer's disease (AD). However, currently used therapeutic agents targeting peripheral Aβ cannot simultaneously achieve plasma Aβ enrichment and enhanced clearance, which may result in poor bioavailability and rather low efficacy. Moreover, most of therapeutic agents usually promote the unfavorable aggregation of Aβ....
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