Amirhossein Sahebkar
Mashhad University of Medical Sciences
CancerInternal medicineEndocrinologyRandomized controlled trialChemistryImmunologyPlaceboOxidative stressInflammationCurcuminDiseaseCancer researchClinical trialDiabetes mellitusBioinformaticsMedicineBiologyGastroenterologyMeta-analysisPharmacology
1,256Publications
111H-index
36kCitations
Publications 1,367
Newest
#1Tannaz Jamialahmadi (IAU: Islamic Azad University)H-Index: 15
#2Paul C. Guest (State University of Campinas)H-Index: 14
Last. Amirhossein Sahebkar (MUMS: Mashhad University of Medical Sciences)H-Index: 111
view all 5 authors...
Colorectal cancer is the third most common cancer and accounts for the second highest number of cancer-related deaths worldwide. Natural products such as the turmeric-derived curcuminoids are known to have protective effects against several kinds of cancers by acting as antioxidant and anti-inflammatory agents. Here, we present a protocol for assessing the effects of curcuminoids on serum cytokine profiles in a double-blind placebo-controlled trial of patients with stage 3 colorectal cancer unde...
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#1Tannaz Jamialahmadi (MUMS: Mashhad University of Medical Sciences)H-Index: 15
#2Paul C. Guest (State University of Campinas)H-Index: 14
Last. Amirhossein Sahebkar (MUMS: Mashhad University of Medical Sciences)H-Index: 111
view all 5 authors...
This chapter presents a protocol for studying the effects of curcumin in a colorectal cell line and a mouse model of colitis-associated colon carcinogenesis. The protocol using the CT26 cell line incorporates cell proliferation, migration, invasion, spheroid formation, cell cycle, polymerase chain reaction (PCR), and western blot analyses. For the mouse model, this involved a macroscopic and histological examination of the colon and assays for oxidative damage markers.
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#1Mohammad Jalili-Nik (MUMS: Mashhad University of Medical Sciences)H-Index: 11
#2Khadijeh Mahboobnia (Ahvaz Jundishapur University of Medical Sciences)H-Index: 3
Last. Amirhossein Sahebkar (MUMS: Mashhad University of Medical Sciences)H-Index: 111
view all 7 authors...
Elevated levels of plasma low-density lipoprotein cholesterol (LDL-C) are causally related to atherosclerotic cardiovascular disease. Enhancing the removal of LDL particles from the plasma, mainly by the liver, is the most efficient strategy for reducing LDL-C and the ensuing atherosclerosis. In this context, polyphenolic compounds like curcumin have generated interest owing to their lipid-modifying capacity. The promising effect of curcumin has been studied in attenuating atherosclerosis (in ex...
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#1Mohammad Jalili-Nik (MUMS: Mashhad University of Medical Sciences)H-Index: 11
#2Amir R. AfshariH-Index: 13
Last. Amirhossein Sahebkar (MUMS: Mashhad University of Medical Sciences)H-Index: 111
view all 6 authors...
Glioblastoma multiforme (GBM) is an aggressive tumor in the central nervous system with a poor prognosis. Currently, the main interventions include surgery, chemotherapy, and radiotherapy. Recently, several natural products have been reported as potentially effective and safer treatment options. Here, we studied the effects of zerumbone, a sesquiterpene compound derived from Zingiber zerumbet Smith rhizomes, on human GBM U-87 MG cells in vitro. To meet this purpose, we used a cytotoxicity assay,...
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#1Tannaz Jamialahmadi (IAU: Islamic Azad University)H-Index: 15
#2Yunes Panahi (BMSU: Baqiyatallah University of Medical Sciences)H-Index: 39
Last. Amirhossein Sahebkar (MUMS: Mashhad University of Medical Sciences)H-Index: 111
view all 5 authors...
Oxidative stress has a key role in the pathogenesis of type 2 diabetes mellitus. Alternative therapy with antioxidants has been tested as a potential approach to curb the effects of this disorder. Here, we present a protocol to set up a randomized double-blind placebo-controlled trial to assess the impact of treatment with a mixture of curcuminoids on a number of physiological and molecular biomarker measures with the main focus on determining the total antioxidant capacity.
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#1Tannaz Jamialahmadi (IAU: Islamic Azad University)H-Index: 15
#2Paul C. Guest (State University of Campinas)H-Index: 14
Last. Amirhossein Sahebkar (MUMS: Mashhad University of Medical Sciences)H-Index: 111
view all 5 authors...
Disturbances in the prooxidant-antioxidant balance can occur in metabolic syndrome. Here, we present a protocol for the setup of a clinical trial of metabolic syndrome patients treated with berberine, a dietary phytochemical of the Berberis vulgaris plant, or placebo. The main aim is to obtain a quick and real-time assessment on the overall redox state based on measurement of the prooxidant-antioxidant balance.
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#1Naser-Aldin Lashgari (IAU: Islamic Azad University)H-Index: 4
#2Nazanin Momeni Roudsari (IAU: Islamic Azad University)H-Index: 5
Last. Amirhossein Sahebkar (MUMS: Mashhad University of Medical Sciences)H-Index: 111
view all 6 authors...
Parkinson's disease (PD) is a neurodegenerative disorder in which inflammation and oxidative stress play key etiopathological role. The pathology of PD brain is characterized by inclusions of aggregated α-synuclein (α-SYN) in the cytoplasmic region of neurons. Clinical evidence suggests that stimulation of pro-inflammatory cytokines leads to neuroinflammation in the affected brain regions. Upon neuroinflammation, the Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) sign...
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#1Fatemeh Zahedipour (MUMS: Mashhad University of Medical Sciences)H-Index: 5
#2Parvin Zamani (MUMS: Mashhad University of Medical Sciences)H-Index: 13
Last. Amirhossein Sahebkar (MUMS: Mashhad University of Medical Sciences)H-Index: 111
view all 5 authors...
Abstract null null Angiogenesis has a significant role in metastasis and progression of melanoma. Even small tumors may be susceptible to metastasis and hence lead to a worse outcome in patients with melanoma. One of the anti-angiogenic treatment approaches that is undergoing comprehensive study is specific immunotherapy. While tumor cells are challenging targets for immunotherapy due to their genetic instability and heterogeneity, endothelial cells (ECs) are genetically stable. Therefore, vacci...
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#1Amir Vahedian-Azimi (BMSU: Baqiyatallah University of Medical Sciences)H-Index: 16
Last. Amirhossein Sahebkar (MUMS: Mashhad University of Medical Sciences)H-Index: 111
view all 5 authors...
Abstract null null Importance null The difference in clinical outcomes between closed and open designs of intensive care units (ICUs) is still an open question. null null null Objective null We conducted a systematic review and meta-analysis to compare total mortality, hospital and ICU length of stay (LOS) and mortality as primary outcomes, and severity of illness based on physiological variables, organ failure assessment, age, duration of mechanical ventilation and ventilator-associated pneumon...
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#1Gholamreza Askari (IUMS: Isfahan University of Medical Sciences)H-Index: 27
#2Babak Alikiaii (IUMS: Isfahan University of Medical Sciences)H-Index: 4
Last. Mohammad Bagherniya (IUMS: Isfahan University of Medical Sciences)H-Index: 11
view all 8 authors...
OBJECTIVES: This study aims to investigate the efficacy of curcumin-piperine co-supplementation on oxidative stress factors, clinical symptoms, and mortality rate in patients with coronavirus (COVID-19) admitted to the intensive care unit (ICU). TRIAL DESIGN: This study is a randomized, placebo-controlled, double-blind, parallel-arm clinical trial. PARTICIPANTS: The study participants will be recruited from patients admitted to the ICU of Al-Zahra hospital with a definitive diagnosis of COVID-19...
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