Setup and validation of shake-flask procedures for the determination of partition coefficients (logD) from low drug amounts
Abstract
Several procedures based on the shake-flask method and designed to require a minimum amount of drug for octanol-water partition coefficient determination have been established and developed. The procedures have been validated by a 28 substance set with a lipophilicity range from -2.0 to 4.5 (logD7.4). The experimental partition is carried out using aqueous phases buffered with phosphate (pH 7.4) and n-octanol saturated with buffered water and...
Paper Details
Title
Setup and validation of shake-flask procedures for the determination of partition coefficients (logD) from low drug amounts
Published Date
Aug 1, 2015
Volume
76
Pages
181 - 191
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