Reliability of a new modified tear breakup time method: dry tear breakup time

Published on Jun 20, 2015in Graefes Archive for Clinical and Experimental Ophthalmology3.117
· DOI :10.1007/S00417-015-3080-5
Kyung Tae Kim4
Estimated H-index: 4
(CBNU: Chungbuk National University),
Jae-hyung Kim3
Estimated H-index: 3
(CBNU: Chungbuk National University)
+ 2 AuthorsSungmin Hyung4
Estimated H-index: 4
(CBNU: Chungbuk National University)
Sources
Abstract
Background Tear breakup time (TBUT) is a useful technique for diagnosing dry eye disease (DED). The conventional method of measuring TBUT using fluorescein strips adds supplemental normal saline (NS) to the tear film (wet tear breakup time, WBUT) but does not represent the actual state of the tear film. We introduced a new TBUT method—dry tear breakup time (DBUT)—and investigated its reliability.
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References22
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#1Bennie H. Jeng (UCSF: University of California, San Francisco)H-Index: 1
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#1Cheol Min Yun (KU: Korea University)H-Index: 4
#2Su Yeon Kang (KU: Korea University)H-Index: 13
Last. Jong Suk Song (KU: Korea University)H-Index: 22
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Abstract Purpose To (i) analyze the repeatability of fluorescein instillation from a modified fluorescein strip (MFS) compared to a standard fluorescein strip (FS), and to (ii) observe its usefulness in the measurement of the fluorescein break-up time (FBUT) in comparison to the Tearscope (NIBUT). Methods In-vitro : Intra- and inter-observer repeatability in fluorescein instillation from the MFS and FS was evaluated by fluorescence analysis ( n =10, each). In-vivo : BUT of the right eye of 20 ra...
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PURPOSE: A prospective, multisite clinical study (10 sites in the European Union and the United States) evaluated the clinical utility of commonly used tests and tear osmolarity for assessing dry eye disease severity. METHODS: Three hundred fourteen consecutive subjects between the ages of 18 and 82 years were recruited from the general patient population, 299 of which qualified with complete datasets. Osmolarity testing, Schirmer test without anesthesia, tear film breakup time (TBUT), corneal s...
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#1Gary N. Foulks (University of Louisville)H-Index: 55
Dry eye, also known as keratoconjunctivitis sicca, can be due either to insufficient tear production or excessive tear evaporation, both resulting in tear hyperosmolarity that leads to symptoms of discomfort and ocular damage. Additionally, the severity of dry eye symptoms appears to be correlated to lipid layer thickness. It is now generally recognized that increased evaporation due to a compromised lipid layer is one of the most common etiologies for hyperosmolarity of the tear film. Thus, the...
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#1Anthony J. BronH-Index: 57
#2Mark B. AbelsonH-Index: 57
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#1Alan Tomlinson (Vision-Sciences, Inc.)H-Index: 47
#2Santosh Khanal (Vision-Sciences, Inc.)H-Index: 12
Last. Angus McFadyen (GCU: Glasgow Caledonian University)H-Index: 32
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PURPOSE. To determine new referents, or cutoff levels for tear film hyperosmolarity in the diagnosis of keratoconjunctivitis sicca (KCS) and to assess their effectiveness in independent patient groups. METHOD. A meta-analysis was performed on published data for tear osmolarity in samples of normal eyes and various subtypes of dry eye, and pooled estimates of the mean and standard deviations for normal and (all) dry eye subjects were determined. Diagnostic referents were derived from the intercep...
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#1Michael E. Johnson (Cardiff University)H-Index: 7
#2Paul J. MurphyH-Index: 26
Purpose: To investigate how the volume of instilled fluorescein solution alters invasive tear breakup time (TBUT) and the standard deviation (SD) of multiple recordings, and to determine the volume of fluid supplied by traditional fluorescein-impregnated strips (FS) and a micropipette calibrated to dispense 1 μL. Methods: TBUT was measured 3 times in the right eyes of 46 subjects following the instillation of 1, 2.7, and 7.4 μL of fluorescein solution by micropipette and the use of a wetted FS. ...
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#2Su Ying Tsai (NYMU: National Yang-Ming University)H-Index: 11
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Abstract Purpose To describe the epidemiology of dry eye in an elderly Chinese population in Taipei, Taiwan. Design A population-based cross-sectional study. Participants The Shihpai Eye Study was a population-based survey of eye diseases in the elderly (≥65 years) in Shihpai, Taipei, Taiwan. Noninstitutionalized residents, as of July 1999, were identified by using the official household registration database. A total of 2045 subjects were selected, and 1361 (66.6%) people participated in the st...
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This study aims to investigate the reliability and efficacy of maximum fluorescein tear break-up time (FTBUTmax) in diagnosing dry eye disease (DED). 147 participants were enrolled in this study. Ocular symptoms were assessed by Ocular Surface Disease Index (OSDI). The fluorescein tear break-up time (FTBUT) examination, corneal fluorescein staining (CFS), and Schirmer I test were performed on both eyes. Each participant underwent 3 consecutive FTBUT tests, and five types of FTBUT values includin...
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This study evaluated to what extent tear film break-up time (TFBUT) could discriminate pathological scores for other clinical tests and explore the associations between them. Dry eye patients (n = 2094) were examined for ocular surface disease index (OSDI), tear film osmolarity (Osm), TFBUT, blink interval, ocular protection index (OPI), ocular surface staining (OSS), Schirmer I test, meibomian expressibility, meibomian quality, and meibomian gland dysfunction. The results were grouped into eigh...
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The role of the Tear Film and Ocular Surface Society (TFOS) Dry Eye Workshop (DEWS) II Diagnostic Methodology Subcommittee was 1) to identify tests used to diagnose and monitor dry eye disease (DED), 2) to identify those most appropriate to fulfil the definition of DED and its sub-classifications, 3) to propose the most appropriate order and technique to conduct these tests in a clinical setting, and 4) to provide a differential diagnosis for DED and distinguish conditions where it is a comorbid...
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#2Srinivasan Sanjay (NUS: National University of Singapore)H-Index: 4
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Abstract Purpose To evaluate the efficacy of infrared (IR) ocular thermography in screening for dry eye disease (DED). Methods IR ocular thermography was performed on 62 dry eye and 63 age- and sex-matched control subjects. Marking of ocular surface and temperature acquisition was done using a novel ‘diamond’ demarcation method. 30 static- and 30 dynamic-metrics were studied and receiver operating characteristic curves were plotted. Efficacy of the temperature metrics in detecting DED were evalu...
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#1Kyung Tae Kim (CBNU: Chungbuk National University)H-Index: 4
#2Jae-hyung Kim (CBNU: Chungbuk National University)H-Index: 3
lies on the misunderstanding of the expression 'replace' in the abstract of the article. Our intention in this study was not to replace the WBUT method completely with the DBUT method for diagnosing dry eye disease, because an AUROC curve of WBUT was less than that of DBUT. Instead, the intention in this study was to intro- duce a new modified diagnostic method. However, we do agree with Dr. Sabour claims that further investiga- tion of other estimates for validity is needed.
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#1Siamak Sabour (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 34
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