PTEN Immunohistochemistry in Breast Carcinoma

Published on Dec 1, 1999in Breast Cancer Research4.988
· DOI :10.1186/bcr-1999-66619
Chris Jones84
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2019
3 Authors (Ping Tang, ..., Yan Peng)
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#1Aurel Perren (OSU: Ohio State University)H-Index: 74
#2Liang Ping Weng (OSU: Ohio State University)H-Index: 9
Last. Charis Eng (University of Cambridge)H-Index: 145
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Germline mutations in PTEN, encoding a dual-specificity phosphatase on 10q23.3, cause Cowden syndrome (CS), which is characterized by a high risk of breast and thyroid cancers. Loss of heterozygosity of 10q22–24 markers and somatic PTEN mutations have been found to a greater or lesser extent in a variety of sporadic component and noncomponent cancers of CS. Among several series of sporadic breast carcinomas, the frequency of loss of flanking markers around PTEN is approximately 30 to 40%, and th...
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