Effect and mechanism of inhibiting ZNF139 on apoptosis in human gastric cancer cell line BGC823

Objective: To investigate the role of ZNF139 played in GC cell apoptosis and to explore its mechanism. Methods: Expression of ZNF139 in GC tissues, adjacent normal tissues, GC cell lines MKN28, SGC7901, BGC823 and in gastric epithelial cell line GES-1 were tested. Then ZNF139-specific siRNA was transfected into BGC823 cells. Viability, cell cycle and apoptosis of GC cells were detected. Survivin, x-IAP, caspase-3, Fas, p53, Bcl-2 and Bax genes...