Transcriptional Regulation By Neuronal Activity: To The Nucleus And Back

Published on Jan 1, 2008
Serena M. Dudek33
Estimated H-index: 33
Preface.- Transcriptional Regulation of Activity-Dependent Genes by Birdsong.- To the Nucleus with Proteomics.- Transcriptional Regulation of the Tbr1-CASK-CINAP Protein Complex in Response to Neuronal Activity.- Intracellular Calcium Waves Transmit Synaptic Information to the Nucleus in Hippocampal Pyramidal Neurons.- Role of Action Potentials in Regulating Gene Transcription: Relevance to LTP.- L-type Channel Regulation of Gene Expression.- CREB-Dependent Transcription and Synaptic Plasticity.- Activity-Dependent Regulation of Brain-derived neurotrophic factor Transcription.- Role of Signal-responsive Class IIa Histone Deacetylases in Regulating Neuronal Activity-dependent Gene Expression.- NFAT-Dependent Gene Expression in the Nervous System: A Critical Mediator of Neurotrophin-Induced Plasticity.- Activity-Dependent Bigenomic Transcriptional Regulation of Cytochrome c Oxidase in Neurons.- Not Just for Muscle Anymore: Activity and Calcium Regulation of MEF2-Dependent Transcription in Neuronal Survival and Differentiation.- Synaptic Growth and Transcriptional Regulation in Drosophila.- MMP-9/TIMP-1 extracellular proteolytic system as AP-1 target in response to neuronal activity.- Activity-dependent Gene Transcription in Neurons: Defining the Plasticity Transcriptome.- Transcriptional Mechanisms Underlying the Mammalian Circadian Clock.- Intersecting Genetics with Lifestyle: the Role of Exercise and Diet in Synaptic Plasticity and Cognitive Enhancement.- CREB Responsive Transcription and Memory Formation.- Dynamic Transcription of the Immediate-Early Gene Arc in Hippocampal Neuronal Networks: Insights into the Molecular and Cellular Bases of Memory Formation.- Index.
📖 Papers frequently viewed together
Cited By7
#1Zhuting LiH-Index: 1
v PREFACE vii TABLE OF CONTENTS viii LIST OF TABLES xi LIST OF FIGURES xii LIST OF ABBREVIATIONS xiv CHAPTER I: INTRODUCTION 1 A. Neuronal activity and energy metabolism 1 1. Energy metabolism: a coordination between two genomes 1 2. Nuclear-encoded regulators of mitochondrial biogenesis: NRF-1 and PGC-1α .... 2 2.1 NRF1 2 2.2 PGC-1α and NRF-1 in neurons 5 B. Epilepsy 8 1. General classification 8 2. Treatment 10 3. Temporal lobe epilepsy (TLE) and animal models 16 3.1 Pilocarpine model of TLE 1...
Cytochrome c oxidase is the terminal enzyme of the mitochondrial electron transport chain, without which oxidative metabolism cannot be carried to completion. It is one of only four unique, bigenomic proteins in mammalian cells. The holoenzyme is made up of three mitochondrial-encoded and ten nuclear-encoded subunits in a 1:1 stoichiometry. The ten nuclear subunit genes are located in nine different chromosomes. The coordinated regulation of such a multisubunit, multichromosomal, bigenomic enzym...
#1Angel BarcoH-Index: 41
#2Hélène Marie (CNRS: Centre national de la recherche scientifique)H-Index: 28
In neurons, the convergence of multiple intracellular signaling cascades leading to cAMP-responsive element-binding protein (CREB) activation suggests that this transcription factor plays a critical role in integrating different inputs and mediating appropriate neuronal responses. The nature of this transcriptional response depends on both the type and strength of the stimulus and the cellular context. CREB-dependent gene expression has been involved in many different aspects of nervous system f...
Abstract Nuclear respiratory factor 1 (NRF-1) is one of the key transcription factors implicated in mitochondrial biogenesis by activating the transcription of mitochondrial transcription factor A (mtTFA) and subunit genes of respiratory enzymes. NRF-1 transactivation activity can be enhanced by interaction with transcription coactivator peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α). The expression of PGC-1α, NRF-1 and mtTFA in neurons is known to be tightly regulated by n...
#1Eva Benito (CSIC: Spanish National Research Council)H-Index: 28
#2Angel Barco (CSIC: Spanish National Research Council)H-Index: 41
The activation of cAMP-response element binding protein (CREB)-dependent gene expression seems a crucial step in the molecular cascade that mediates the formation of long-lasting memories. This view is based both on correlative evidence and on functional assays that demonstrate, through loss- and gain-of-function experiments, the impact of CREB manipulation on memory performance. Mechanistically, CREB's role in memory is thought to be a consequence of its participation in long-term forms of syna...
#1Marco Assunção (University of Porto)H-Index: 13
#2Maria Joao Santos-Marques (University of Porto)H-Index: 7
Last. José Paulo Andrade (University of Porto)H-Index: 25
view all 4 authors...
We previously found that prolonged consumption of green tea (GT), a rich source of antioxidant polyphenols, protected proteins and lipids against oxidation and reduced lipofuscin deposition in the rat hippocampal formation as well as improving spatial memory during aging. In this work, we sought to investigate whether GT treatment could interfere with age-related changes in redox status and cellular signaling systems related to oxidative stress and survival in the same brain region. To address t...
#1Angel Barco (CSIC: Spanish National Research Council)H-Index: 41
#2Mikel Lopez de Armentia (CSIC: Spanish National Research Council)H-Index: 6
Last. Juan Marcos Alarcon (SUNY Downstate Medical Center)H-Index: 18
view all 3 authors...
A decade ago, the synaptic tagging hypothesis was proposed to explain how newly synthesized plasticity products can be specifically targeted to active synapses. A growing number of studies have validated the seminal findings that gave rise to this model, as well as contributed to unveil and expand the range of mechanisms underlying late-associativity and neuronal computation. Here, we will review what it was learnt during this past decade regarding the cellular and molecular mechanisms underlyin...
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.