3 RNA Polymerase II Subunits, Transcription Factors, and Kinases: Investigations in Drosophila melanogaster and Saccharomyces cerevisiae

OVERVIEW An approach combining detailed biochemistry with classic and molecular genetics has led to new insights into the structure and function of RNA polymerase II (pol II), its transcription factors, and a novel RNA pol II kinase. Collections of mutants altered in genes for the two large subunits of RNA pol II will be valuable for elucidating the functions of conserved domains discovered as a consequence of cloning and sequencing the genes. A...