Enhancing cancer targeting and anticancer activity by a stimulus-sensitive multifunctional polymer-drug conjugate
Abstract
Undesirable physicochemical properties, low tumor targeting, insufficient cell internalization, acquired drug resistance, and severe side effects significantly limit the applications of anticancer drugs. In this study, to improve the tumor targeting and drug efficacy of the poorly water-soluble drug, doxorubicin (DOX), a novel drug delivery platform (PEG-ppTAT-DOX) was developed, which contained a polyethylene glycol (PEG), a matrix...
Paper Details
Title
Enhancing cancer targeting and anticancer activity by a stimulus-sensitive multifunctional polymer-drug conjugate
Published Date
Aug 1, 2015
Volume
212
Pages
94 - 102
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