Synthesis and bioevaluation of heterocyclic derivatives of Cleistanthin-A
Abstract
The vacuolar H(+)-ATPase (V-ATPase) was proposed as a key target for new strategies in cancer treatment recently. We have synthesized a novel class of derivatives of Cleistanthin-A bearing heterocyclic moieties. Most of these compounds displayed potent antiproliferative effects on four cancer cells at submicromolar concentration, and they have no cytotoxicity on normal WRL-68 cells at 200 nM. The most potent compound 3a has been shown to inhibit...
Paper Details
Title
Synthesis and bioevaluation of heterocyclic derivatives of Cleistanthin-A
Published Date
Aug 1, 2015
Volume
23
Issue
15
Pages
4884 - 4890
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