Business

Cardiology

Ibuprofen

Ductus arteriosus

Medicine

Pharmacology

New England Journal of Medicine

Expectant management for PDA in extremely premature infants was noninferior to early ibuprofen treatment with respect to necrotizing enterocolitis, bronchopulmonary dysplasia, or death at 36 weeks' postmenstrual age. (Funded by the Netherlands Organization for Health Research and Development and the Belgian Health Care Knowledge Center; BeNeDuctus ClinicalTrials.gov number, NCT02884219; EudraCT number, 2017-001376-28.).

Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus