Linear range

Gene

Statistics

Detection limit

Aptamer

Function (biology)

microRNA

Stage (stratigraphy)

Paleontology

Molecular biology

Biosensor

Nanotechnology

Chemistry

Materials science

Realization (probability)

Mathematics

Chromatography

Biochemistry

Biology

Cell biology

Analytical Chemistry

Realization of a highly sensitive analysis and sensing platform is important for early-stage tumor diagnosis. In this work, a self-powered biosensor with a novel sandwich graphdiyne (SGDY) combined with an aptamer-specific recognition function was developed to sensitively and accurately detect tumor markers. Results indicated that the detection limits of microRNA (miRNA)-21 and miRNA-141 were 0.15 and 0.30 fM (S/N = 3) in the linear range of 0.05–10000 and 1–10000 fM, respectively. The newly designed platform has great promise for early-stage tumor diagnosis.

Real-Time Biosensor Platform Based on Novel Sandwich Graphdiyne for Ultrasensitive Detection of Tumor Marker