Pathology

Pure mathematics

Government (linguistics)

Mathematics

Economic growth

Telepathology

Philosophy

Artificial intelligence

Applications of artificial intelligence

Health care

Economics

Economic shortage

Medical physics

Data science

Digital pathology

Digital image analysis

Telemedicine

Computer science

Linguistics

Field (mathematics)

Computer vision

Medicine

Journal of Pathology Informatics

Digital pathology had a recent growth, stimulated by the implementation of digital Whole Slide Images (WSIs) in clinical practice, and the pathology field faces shortage of pathologists in the last few years. This scenario created fronts of research applying Artificial Intelligence (AI) to help pathologists. One of them is the automated diagnosis, helping in the clinical decision support, increasing efficiency and quality of diagnosis. However, the complexity nature of the WSIs requires special treatments to create a reliable AI model for diagnosis. Therefore, we systematically reviewed the literature to analyze and discuss all the methods and results in AI in digital pathology performed in WSIs on H&E stain, investigating the capacity of AI as a diagnostic support tool for the pathologist in the routine real-world scenario. This review analyzes 26 studies, reporting in detail all the best methods to apply AI as a diagnostic tool, as well as the main limitations, and suggests new ideas to improve the AI field in digital pathology as a whole. We hope that this study could lead to a better use of AI as a diagnostic tool in pathology, helping future researchers in the development of new studies and projects.

Artificial intelligence as a tool for diagnosis in digital pathology whole slide images: A systematic review