Physics

Internal medicine

Enzyme

Heart failure

Cardiology

Volume overload

Chemistry

Volume (thermodynamics)

Carbonic anhydrase

Acetazolamide

Carbonic anhydrase inhibitor

Acute decompensated heart failure

Quantum mechanics

Biochemistry

Medicine

New England Journal of Medicine

Whether acetazolamide, a carbonic anhydrase inhibitor that reduces proximal tubular sodium reabsorption, can improve the efficiency of loop diuretics, potentially leading to more and faster decongestion in patients with acute decompensated heart failure with volume overload, is unclear.

Acetazolamide in Acute Decompensated Heart Failure with Volume Overload