Enteroendocrine cell

Endocrinology

Intraepithelial lymphocyte

Receptor

Immunology

Glucagon-like peptide-1

Inflammation

Type 2 diabetes

Insulin resistance

Insulin

Glucose homeostasis

Endocrine system

Gut flora

Biochemistry

Diabetes mellitus

Hormone

Biology

Immune system

Cell biology

Cell Metabolism

GLP-1 exerts incompletely understood anti-inflammatory actions, as most immune cells do not express the GLP-1R. Here, Wong et al. show that the intestinal intraepithelial lymphocyte GLP-1R is required for actions of GLP-1 on gut microbiota and for selective restraint of local and systemic T cell-induced, but not lipopolysaccharide-induced, inflammation.

Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced inflammation