Pathology

Neurology

Disease

Nausea

Coronavirus disease 2019 (COVID-19)

Infectious disease (medical specialty)

Biology

Gene

Psychiatry

Surgery

Intensive care medicine

Immunology

Monkeypox

Hyposmia

myalgia

Vomiting

Vaccinia

Anorexia

Malaise

Recombinant DNA

Biochemistry

Medicine

Journal of Neurology

Cases of monkeypox (MPV) are sharply rising around the world. While most efforts are being focused on the management of the first symptoms of monkeypox, such as cutaneous lesions and flu-like symptoms, the effect of the monkeypox virus (MPXV) on multiple organs still remains unclear. Recently, several neurological manifestations, such as headache, myalgia, malaise, fatigue, altered consciousness, agitation, anorexia, nausea, and vomiting, have been reported in patients with MPV. In addition, data from experimental studies have indicated that MPXV can gain access to the central nervous system (CNS) through the olfactory epithelium and infected circulatory monocytes/macrophages as two probable neuroinvasive mechanisms. Therefore, there are growing concerns about the long-term effect of MPXV on the CNS and subsequent neurological complications. This paper highlights the importance of the neuroinvasive potential of MPXV, coupled with neurological manifestations.

Monkeypox virus from neurological complications to neuroinvasive properties: current status and future perspectives