X-ray laser

Colloidal gold

Analytical Chemistry (journal)

Absorption spectroscopy

Optics

Physics

Laser ablation synthesis in solution

Absorption (acoustics)

Engineering

Nanomaterials

Aerospace engineering

Physical chemistry

Nanoparticle

Composite material

Nanotechnology

Chemistry

Particle size

Materials science

Laser power scaling

Contrast (vision)

Ablation

Laser ablation

Gum arabic

Food science

Chromatography

Optoelectronics

Laser

Wavelength

Scientific Reports

Laser ablation synthesis in liquid solution (PLAL) is a green technique that allows for the physical formation of nanomaterials. This study indicates the preparation of stable gold nanoparticles (AuNPs) in Gum Arabic (GA) solution via laser ablation as a CT contrast agent. The optical properties were achieved using the absorption spectroscopic technique whereas the morphology and size distribution were investigated by TEM and ImageJ software. TEM image shows greater stability and spherical shape of GA-AuNPs with smaller size at 1.85 ± 0.99&nbsp;nm compared to AuNPs without GA. The absorption spectrum of pure AuNPs has a lower absorption peak height in the visible range at λ = 521&nbsp;nm, while the spectrum of GA-AuNPs has a higher plasmon peak height at λ = 514&nbsp;nm with a blue shift towards lower wavelengths. The concentration of GA that dissolved in 10&nbsp;mL of DI water via laser ablation is set at 20&nbsp;mg. Increasing the number of pulses has only a minor effect on particle size distribution, which remains tiny in the nanometer range (less than 3&nbsp;nm). For energies greater than 200&nbsp;mJ, there is a blue shift toward shorter wavelengths. As the concentration of GA-AuNPs increases, the CT number is also increased indicating good image contrast. It can be concluded that there is a positive and significant influence of GA as a reducing agent for AuNPs, and a contrast agent for CT imaging which highlights its superiority in future medical applications.

Green synthesis of gold nanoparticles in Gum Arabic using pulsed laser ablation for CT imaging