Original paper

Mechanism of β 2 AR regulation by an intracellular positive allosteric modulator

Science56.90
Volume: 364, Issue: 6447, Pages: 1283 - 1287
Published: Jun 28, 2019
Abstract
Positive reinforcement in a GPCR Many drug discovery efforts focus on G protein–coupled receptors (GPCRs), a class of receptors that regulate many physiological processes. An exemplar is the β 2 -adrenergic receptor (β 2 AR), which is targeted by both blockers and agonists to treat cardiovascular and respiratory diseases. Most GPCR drugs target the primary (orthosteric) ligand binding site, but binding at allosteric sites can modulate...
Paper Details
Title
Mechanism of β 2 AR regulation by an intracellular positive allosteric modulator
Published Date
Jun 28, 2019
Journal
Volume
364
Issue
6447
Pages
1283 - 1287
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