Internal medicine

Surgery

Cardiology

Intensive care medicine

Amputation

Gangrene

Vascular surgery

Vascular disease

Cardiac surgery

Revascularization

Critical limb ischemia

Myocardial infarction

Ischemia

Medicine

European Journal of Vascular and Endovascular Surgery

Chronic limb-threatening ischemia (CLTI) is associated with mortality, amputation, and impaired quality of life. These Global Vascular Guidelines (GVG) are focused on definition, evaluation, and management of CLTI with the goals of improving evidence-based care and highlighting critical research needs. The term CLTI is preferred over critical limb ischemia, as the latter implies threshold values of impaired perfusion rather than a continuum. CLTI is a clinical syndrome defined by the presence of peripheral artery disease (PAD) in combination with rest pain, gangrene, or a lower limb ulceration >2 weeks duration.

Global Vascular Guidelines on the Management of Chronic Limb-Threatening Ischemia