Combinations of radiotherapy with immunotherapy in cervical cancer

Published on Jan 1, 2022in Journal of Cancer
4.21
· DOI :10.7150/jca.65074
Xiaojing Yang0 (Department of Radiation Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital), Hanru Ren0 (Pudong Medical Center), Jie Fu0 (Department of Radiation Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital)
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Abstract
Immunotherapy serves as another effective cancer treatment apart from surgery, chemoradiotherapy, and targeted drug therapy. Radiotherapy combined with immunotherapy has significantly improved the effective cure rate for patients in several clinical trials. It subverted the traditional view that radiotherapy kills immune cells and has immunosuppressive effects, indicating a synergistic effect of radiotherapy and immunotherapy. In this article, we reviewed and summarized the molecular mechanism of the combined use of radiotherapy and immunotherapy, as well as the clinical treatment and safety of the combination of the two. We describe the rationale for the integration of radiotherapy and immunotherapy in patients with cervical cancer, present safety and efficacy data that support this combination strategy, and highlight unanswered question sand future research needs. Besides, this study can be referenced for clinicians to guide subsequent clinical medicine.
References74
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